Catalog No.
PHE27801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human USP8 (Lys180-Arg323).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Ubiquitin-specific-processing protease 8, Deubiquitinating enzyme 8, Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin isopeptidase Y, KIAA0055, USP8, UBPY, hUBPy, Ubiquitin thioesterase 8
Purification
Purified by antigen affinity column.
Accession
P40818
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
PAK5 promotes the trastuzumab resistance by increasing HER2 nuclear accumulation in HER2-positive breast cancer., PMID:40258843
The exploration of high production of tiancimycins in Streptomyces sp. CB03234-S revealed potential influences of universal stress proteins on secondary metabolisms of streptomycetes., PMID:39702388
NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck., PMID:34465724
ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells., PMID:31443721
Therapeutic Approaches for the Treatment of Epidermal Growth Factor Receptor Mutated Lung Cancer., PMID:28669334
The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation., PMID:27203743
USP8 modulates ubiquitination of LRIG1 for Met degradation., PMID:24828152
Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB., PMID:23477725
14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase., PMID:17720156
A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes., PMID:16771824
The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells., PMID:15342353
For research use only. Not for human or drug use.
