Catalog No.
PHE81601
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human RORC/NR1F3/RORgT (Glu212-Ser461).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
RAR-related orphan receptor C, RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Retinoid-related orphan receptor-gamma, RZRG, Nuclear receptor subfamily 1 group F member 3, RORG, RORgT
Purification
Purified by antigen affinity column.
Accession
P51449
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging., PMID:40366697
RORc-expressing immune cells negatively regulate tertiary lymphoid structure formation and support their pro-tumorigenic functions., PMID:39710149
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
BATF-dependent Th17 cells act through the IL-23R pathway to promote prostate adenocarcinoma initiation and progression., PMID:38833676
Intestinal overgrowth of Candida albicans exacerbates bleomycin-induced pulmonary fibrosis in mice with dysbiosis., PMID:37565293
The β2-adrenergic receptor agonist terbutaline upregulates T helper-17 cells in a protein kinase A-dependent manner., PMID:37438188
Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts., PMID:37367825
Release from persistent T cell receptor engagement and blockade of aryl hydrocarbon receptor activity enhance IL-6-dependent mouse follicular helper T-like cell differentiation in vitro., PMID:37352327
T-BET and EOMES sustain mature human NK cell identity and antitumor function., PMID:37279078
IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice., PMID:36988516
In vitro treatment of murine splenocytes with extracellular vesicles derived from mesenchymal stem cells altered the mRNA levels of the master regulator genes of T helper cell subsets., PMID:36720794
Anti-PD-1 antibody-activated Th17 cells subvert re-invigoration of antitumor cytotoxic T-lymphocytes via myeloid cell-derived COX-2/PGE2., PMID:36074159
Changes in Th9 and Th17 lymphocytes and functional cytokines and their relationship with thyroid-stimulating hormone receptor antibodies at different stages of graves' disease., PMID:35935994
Peyer's patch TH17 cells are dispensable for gut IgA responses to oral immunization., PMID:35776804
Mesenchymal Stem Cell-Secreted TGF-β1 Restores Treg/Th17 Skewing Induced by Lipopolysaccharide and Hypoxia Challenge via miR-155 Suppression., PMID:35313652
Transcriptional programming and gene regulation in WC1+ γδ T cell subpopulations., PMID:34959072
Therapeutic Potential of a Novel Bifidobacterium Identified Through Microbiome Profiling of RA Patients With Different RF Levels., PMID:34867956
Hijacking Sexual Immuno-Privilege in GBM-An Immuno-Evasion Strategy., PMID:34681642
Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation., PMID:34606847
T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of RORγt expression and function., PMID:34462459
Immune Responses Vary in Preinvasive Colorectal Lesions by Tumor Location and Histology., PMID:34341013
B cell residency but not T cell-independent IgA switching in the gut requires innate lymphoid cells., PMID:34187897
Immune-related genes and gene sets for predicting the response to anti-programmed death 1 therapy in patients with primary or metastatic non-small cell lung cancer., PMID:34084219
RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma., PMID:34022896
Preinvasive Colorectal Lesions of African Americans Display an Immunosuppressive Signature Compared to Caucasian Americans., PMID:33987094
Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves' Disease., PMID:33912135
Regulatory T Cells Developing Peri-Weaning Are Continually Required to Restrain Th2 Systemic Responses Later in Life., PMID:33613522
Anti-DLL4 ameliorates toluene diisocyanate-induced experimental asthma by inhibiting Th17 response., PMID:33578263
Using RNA-seq to Assess Off-Target Effects of Antisense Oligonucleotides in Human Cell Lines., PMID:33314011
Anti-PD-1 antibody-mediated activation of type 17 T-cells undermines checkpoint blockade therapy., PMID:33245376
Role of the IL-23-T-bet/GATA3 Axis for the Pathogenesis of Ulcerative Colitis., PMID:33040251
Chlorogenic acid ameliorated allergic rhinitis-related symptoms in mice by regulating Th17 cells., PMID:33015714
Dietary and Microbial Determinants in Food Allergy., PMID:32814026
RORC overexpression as a sign of Th17 lymphocytes accumulation in multiple myeloma bone marrow., PMID:32707421
Effects of protein-protein interface disruptors at the ligand of the glucocorticoid-induced tumor necrosis factor receptor-related gene (GITR)., PMID:32569630
Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function., PMID:32388860
Protein-protein interactions: a structural view of inhibition strategies and the IL-23/IL-17 axis., PMID:32312425
RORγT is overexpressed in iNKT and γδ T cells during relapse in relapsing-remitting multiple sclerosis., PMID:31505409
Retinoic acid receptor-related orphan receptor gamma-t (RORγt) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present)., PMID:31403347
Porphyromonas gingivalis lipopolysaccharide promotes T- helper 17 cell differentiation from human CD4+ naïve T cells via toll-like receptor-2 in vitro., PMID:31351339
Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1., PMID:31304630
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice., PMID:31302143
Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet., PMID:31178059
The T helper type 17/regulatory T cell imbalance was associated with Ras-GTPase overexpression in patients with pulmonary hypertension associated with chronic obstructive pulmonary disease., PMID:31141166
NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3., PMID:31130368
Epigallocatechin gallate ameliorates airway inflammation by regulating Treg/Th17 imbalance in an asthmatic mouse model., PMID:31030098
Medroxyprogesterone Acetate Decreases Th1, Th17, and Increases Th22 Responses via AHR Signaling Which Could Affect Susceptibility to Infections and Inflammatory Disease., PMID:31001262
Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease., PMID:30972425
Downregulation of T-Cell Transcription Factors in Adult Latent Autoimmune Diabetes with High-Titer Glutamic Acid Decaroxylase Antibody., PMID:30895467
Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples., PMID:30833191
For research use only. Not for human or drug use.
