Catalog No.
PHE72501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human GZMK (Ile27-Asn264).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
NK-tryptase-2,Fragmentin-3,Granzyme K,GZMK,Granzyme-3,TRYP2,NK-Tryp-2
Purification
Purified by antigen affinity column.
Accession
P49863
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models., PMID:39887656
Single-cell transcriptomics reveal potent extrafollicular B cell response linked with granzyme K+ CD8 T cell activation in lupus kidney., PMID:39419536
Neoadjuvant toripalimab plus axitinib for clear cell renal cell carcinoma with inferior vena cava tumor thrombus: NEOTAX, a phase 2 study., PMID:39362847
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue., PMID:38834551
CD8+ tissue-resident memory T cells are expanded in primary Sjögren's disease and can be therapeutically targeted by CD103 blockade., PMID:38777379
Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases., PMID:38751645
The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma., PMID:38734159
Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque., PMID:38707998
Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma., PMID:38245530
Identification and Preliminary Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Hashimoto's Thyroiditis by Comprehensive Analysis., PMID:38137348
Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease., PMID:38092138
Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD., PMID:37652139
Autoimmune thyroid disease disrupts immune homeostasis in the endometrium of unexplained infertility women-a single-cell RNA transcriptome study during the implantation window., PMID:37501789
Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis., PMID:36658110
Single-cell transcriptomics in bone marrow delineates CD56dimGranzymeK+ subset as intermediate stage in NK cell differentiation., PMID:36505452
Decreased expression of T-cell-associated immune markers predicts poor prognosis in patients with follicular lymphoma., PMID:34837284
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma., PMID:34715028
CD3D, GZMK, and KLRB1 Are Potential Markers for Early Diagnosis of Rheumatoid Arthritis, Especially in Anti-Citrullinated Protein Antibody-Negative Patients., PMID:34603038
Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients., PMID:34376481
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer., PMID:33958794
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging., PMID:33271118
Anti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies., PMID:31439037
Antigen-specificity of antiretinal antibodies in patients with noninfectious uveitis., PMID:28985805
Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin., PMID:25889530
Role of the inflammatory protein serine protease inhibitor Kazal in preventing cytolytic granule granzyme A-mediated apoptosis., PMID:22043941
Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis., PMID:21666061
For research use only. Not for human or drug use.
