Catalog No.
PHE67601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CASP4 (Asn78-Glu265).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Mih1,ICH2,CASP-4,ICE and Ced-3 homolog 2,CASP4,Protease TX,Caspase-4,ICE(rel)-II,ICH-2
Purification
Purified by antigen affinity column.
Accession
P49662
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis., PMID:39143049
Exploring the relationship between pyroptosis, infiltrating immune cells and Kawasaki disease with resistance to intravenous immunoglobulin (IVIG) via bioinformatic analysis., PMID:36029669
Luteolin activates Tregs to promote IL-10 expression and alleviating caspase-11-dependent pyroptosis in sepsis-induced lung injury., PMID:34246059
Alendronate Augments Lipid A-Induced IL-1α Release via Activation of ASC but Not Caspase-11., PMID:34080091
The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis., PMID:33731931
Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity., PMID:32332737
Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses., PMID:30206376
Expression and regulation of alarmin cytokine IL-1α in human retinal pigment epithelial cells., PMID:29551335
Zoledronic acid overcomes chemoresistance by sensitizing cancer stem cells to apoptosis., PMID:29300112
Caspase-11 deficiency impairs neutrophil recruitment and bacterial clearance in the early stage of pulmonary Klebsiella pneumoniae infection., PMID:28939441
Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release., PMID:28796264
Effects of PPARα inhibition in head and neck paraganglioma cells., PMID:28594934
Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release., PMID:27624102
Overexpression of caspase 1 in apoptosis-resistant astrocytes infected with the BeAn Theiler's virus., PMID:26567013
Bevacizumab induces A549 cell apoptosis through the mechanism of endoplasmic reticulum stress in vitro., PMID:26191230
Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules., PMID:25795756
NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis., PMID:25695505
Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes., PMID:25541254
Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock., PMID:24456467
Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells., PMID:23396089
Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cells., PMID:21214890
Genetic profiling of non-Hodgkin's lymphoma with or without hepatitis C virus infection., PMID:23082489
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells., PMID:19059936
Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush., PMID:18775855
Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways., PMID:17570595
Proteomics analysis of H-RAS-mediated oncogenic transformation in a genetically defined human ovarian cancer model., PMID:15940260
Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin., PMID:14695155
Cytokine regulation of human intestinal primary epithelial cell susceptibility to Fas-mediated apoptosis., PMID:11751162
IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death., PMID:11254704
For research use only. Not for human or drug use.
