Anti-NAMPT Polyclonal Antibody

Catalog No.

PHE43301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NAMPT (Met1-His491).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

NAMPT,Pre-B-cell colony-enhancing factor 1,NAmPRTase,Pre-B cell-enhancing factor,Nicotinamide phosphoribosyltransferase,Visfatin,PBEF,PBEF1,Nampt

Purification

Purified by antigen affinity column.

Accession

P43490

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Anti-CHI3L1 antibody suppresses colon cancer growth through downregulation of VEGFA and NAMPT expression., PMID:40377878

NAMPT regulates mitochondria and oxidative stress level for mouse early embryo development., PMID:40320561

eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis., PMID:40126452

Research progress in bifunctional small molecules for cancer immunotherapy., PMID:39919914

The Gut Microbiota Affects Anti-TNF Responsiveness by Activating the NAD+ Salvage Pathway in Ulcerative Colitis., PMID:39739648

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) drives abnormal pericyte-rich vasculature in triple-negative breast cancer., PMID:39636369

CD38 ligation in sepsis promotes nicotinamide phosphoribosyltransferase-mediated IL-6 production in kidney stromal cells., PMID:39568061

Inhibition of ethanol-induced eNAMPT secretion attenuates liver ferroptosis through BAT-Liver communication., PMID:39059204

eNAMPT is a novel therapeutic target for mitigation of coronary microvascular disease in type 2 diabetes., PMID:38898303

Identifying hub genes in response to ustekinumab and the impact of ustekinumab treatment on fibrosis in Crohn's disease., PMID:38840917

Extracellular Nicotinamide Phosphoribosyltransferase Is a Therapeutic Target in Experimental Necrotizing Enterocolitis., PMID:38790933

Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives., PMID:38244254

Antibody drug conjugates beyond cytotoxic payloads., PMID:37981349

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer., PMID:37880182

Single-Cell Network-Based Drug Repositioning for Discovery of Therapies against Anti-Tumour Necrosis Factor-Resistant Crohn's Disease., PMID:37762402

SARS-CoV-2 infection dysregulates NAD metabolism., PMID:37457744

Recent advances of targeting nicotinamide phosphoribosyltransferase (NAMPT) for cancer drug discovery., PMID:37413882

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway., PMID:37173894

Involvement of eNAMPT/TLR4 inflammatory signaling in progression of non-alcoholic fatty liver disease, steatohepatitis, and fibrosis., PMID:36809677

Review of various NAMPT inhibitors for the treatment of cancer., PMID:36160449

A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy., PMID:35658441

Is eNAMPT/visfatin a potential serum marker of papillary thyroid cancer?, PMID:35450096

eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis., PMID:35167418

Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets., PMID:34948292

Cisplatin resistance of NSCLC cells involves upregulation of visfatin through activation of its transcription and stabilization of mRNA., PMID:34656559

Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization., PMID:34139379

Radiation exposure triggers the malignancy of non‑small cell lung cancer cells through the activation of visfatin/Snail signaling., PMID:33432364

The role of visfatin and resistin in an in vitro model of obesity-induced invasive liver cancer., PMID:33356858

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody., PMID:33243842

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion., PMID:33171124

Crucial transcripts predict response to initial immunoglobulin treatment in acute Kawasaki disease., PMID:33082496

Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target., PMID:33045468

Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells., PMID:32597148

Anti-Cancer Activity of PAK4/NAMPT Inhibitor and Programmed Cell Death Protein-1 Antibody in Kidney Cancer., PMID:35224510

Neutralization of extracellular NAMPT (nicotinamide phosphoribosyltransferase) ameliorates experimental murine colitis., PMID:32338310

Role of Nampt overexpression in a rat model of Hashimoto's thyroiditis and its mechanism of action., PMID:32256774

Bioactive fractions from Securidaca inappendiculata alleviated collagen-induced arthritis in rats by regulating metabolism-related signaling., PMID:32187848

Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α., PMID:32142369

Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells., PMID:31957305

Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma., PMID:31952784

Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis., PMID:31415077

Multi-dimensional immunoproteomics coupled with in vitro recapitulation of oncogenic NRASQ61R identifies diagnostically relevant autoantibody biomarkers in thyroid neoplasia., PMID:31326556

Controlling cellular distribution of drugs with permeability modifying moieties., PMID:31303996

Monoclonal antibody AC10364 inhibits cell proliferation in 5-fluorouracil resistant hepatocellular carcinoma via apoptotic pathways., PMID:31303763

Visfatin Promotes Wound Healing through the Activation of ERK1/2 and JNK1/2 Pathway., PMID:30463229

Clinical Significance of Serum Visfatin in Renal Transplant Recipients., PMID:30316365

Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates., PMID:30242091

Nicotinamide Phosphate Transferase (NAMPT) Increases in Plasma in Patients with Acute Coronary Syndromes, and Promotes Macrophages to M2 Polarization., PMID:30158377

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates., PMID:30128077

NAMPT: A pleiotropic modulator of monocytes and macrophages., PMID:30031171

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