Catalog No.
YMG26701
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Thr52-Ser152
Predicted molecular weight
39.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8R2Q8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD317, BST-2, HM1.24 antigen, Bst2, Bone marrow stromal antigen 2
Adaptor Protein Complexes in HIV-1 Pathogenesis: Mechanisms and Therapeutic Potential., PMID:40431726
Unphosphorylated STAT1 binds to the BST2 transcription promoter, promoting increased AKBA anchoring on HPMECs to alleviate ARDS., PMID:40307322
The Deubiquitinase OTUD1 Influences HIV-1 Release by Regulating the Host Restriction Factor BST-2., PMID:40007014
Bone marrow stromal cell antigen 2 is broadly expressed in the different pluripotent states of human pluripotent stem cells and regulates the expression of pluripotency genes and three germ layer markers., PMID:39718725
Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis., PMID:39696540
Antagonism of BST2/Tetherin, a new restriction factor of respiratory syncytial virus, requires the viral NS1 protein., PMID:39561185
Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis., PMID:39558134
A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24., PMID:39173946
Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2., PMID:38747016
PRRX1 upregulates PD-L1 in human mesenchymal stem cells., PMID:38664281
IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling., PMID:38602878
Improved therapeutic consistency and efficacy of CD317+ MSCs through stabilizing TSG6 by PTX3., PMID:38539221
Novel Diagnostic Biomarker BST2 Identified by Integrated Transcriptomics Promotes the Development of Endometriosis via the TNF-α/NF-κB Signaling Pathway., PMID:38441813
Identifying a core protein signature of small extracellular vesicles derived from B-cell precursor acute lymphoblastic leukaemia., PMID:38441169
Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway., PMID:38360199
Antiviral factors and their counteraction by HIV-1: many uncovered and more to be discovered., PMID:38318650
BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1., PMID:38197534
Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin., PMID:38190411
Higher BST2 Expression Promotes the Anti-HBV Effect of IFN-α and BST2 Genetic Variant Predicts PegIFNα Treatment Response of HBeAg-Positive Chronic Hepatitis B Patients., PMID:38018367
Human BST2 inhibits rabies virus release independently of cysteine-linked dimerization and asparagine-linked glycosylation., PMID:37922253
Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin., PMID:37858466
Inflammation-inducible promoters to overexpress immune inhibitory factors by MSCs., PMID:37742038
The autophagy-related protein ATG5 is a central mediator of a non-canonical autophagy pathway hijacked by HIV-1 to weaken the host's response to infection., PMID:37424095
Chimeric antigen receptor T cell-based targeting of CD317 as a novel immunotherapeutic strategy against glioblastoma., PMID:37335916
Understanding how transmembrane domains regulate interactions between human BST-2 and the SARS-CoV-2 accessory protein ORF7a., PMID:37211321
CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation., PMID:37210387
Promotion of BST2 expression by the transcription factor IRF6 affects the progression of endometriosis., PMID:37143676
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway., PMID:36929425
The roles of BST-2 in murine B cell development and on virus propagation., PMID:36604771
Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin., PMID:36602368
BST2 induced macrophage M2 polarization to promote the progression of colorectal cancer., PMID:36594082
A functional variant of CD40 modulates clearance of hepatitis B virus in hepatocytes via regulation of the ANXA2/CD40/BST2 axis., PMID:36383401
Multi-functional BST2/tetherin against HIV-1, other viruses and LINE-1., PMID:36176574
CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription., PMID:35864225
Bone marrow stromal cell antigen 2(BST2) suppresses the migration and invasion of trophoblasts in preeclampsia by downregulating matrix metallopeptidase 2(MMP2)., PMID:35635087
Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients., PMID:35081977
Catch Me if You Can: the Crosstalk of Zika Virus and the Restriction Factor Tetherin., PMID:34935441
Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing., PMID:34911770
Interferon-α exerts proinflammatory properties in experimental radiation-induced esophagitis: Possible involvement of plasmacytoid dendritic cells., PMID:34890590
Simian Immunodeficiency Virus SIVgsn-99CM71 Vpu Employs Different Amino Acids To Antagonize Human and Greater Spot-Nosed Monkey BST-2., PMID:34878886
APOBEC3, TRIM5α, and BST2 polymorphisms in healthy individuals of various populations with special references to its impact on HIV transmission., PMID:34863878
Regulation of Viral Restriction by Post-Translational Modifications., PMID:34835003
Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin., PMID:34791819
BST2 Suppresses LINE-1 Retrotransposition by Reducing the Promoter Activity of LINE-1 5' UTR., PMID:34730388
Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization., PMID:34692852
High-Throughput NanoBiT-Based Screening for Inhibitors of HIV-1 Vpu and Host BST-2 Protein Interaction., PMID:34502213
Recombinant expression, purification, and characterization of full-length human BST-2 from Escherichia coli., PMID:34500069
Epigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis., PMID:34025670
Functional landscape of SARS-CoV-2 cellular restriction., PMID:33930332
CD317 puts the brakes on dendritic cell trafficking to the CNS., PMID:33850053
For research use only. Not for human or drug use.
