Catalog No.
YMJ27901
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Gln42-Ser229
Predicted molecular weight
22.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ES57
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mox2r, Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Ox2r, Cd200r1, Cell surface glycoprotein OX2 receptor 1
CD200R1-CD200 checkpoint inhibits phagocytosis differently from SIRPα-CD47 to suppress tumor growth., PMID:40461553
Profiling 92 circulating neurobiological proteins identifies novel candidate biomarkers of long-term cognitive outcome after ischemic stroke., PMID:40316737
Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study., PMID:40312358
[The role of microglia activated by the deletion of immune checkpoint receptor CD200R1 gene in a mouse model of Parkinson's disease]., PMID:40065611
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088
Effects of Oral Administration of the Probiotic Lactobacillus rhamnosus GG on the Proteomic Profiles of Cerebrospinal Fluid and Immunoregulatory Signaling in the Hippocampus of Adult Male Rats., PMID:40031897
Potential drug targets for asthma identified through mendelian randomization analysis., PMID:39806440
First-in-Human Study of 23ME-00610, an Antagonistic Antibody for Genetically Validated CD200R1 Immune Checkpoint, in Participants with Advanced Solid Malignancies., PMID:39651931
CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody., PMID:39402718
Microglial priming by IFN-γ involves STAT1-mediated activation of the NLRP3 inflammasome., PMID:39392762
Deep Immune and RNA Profiling Revealed Distinct Circulating CD163+ Monocytes in Diabetes-Related Complications., PMID:39337580
The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease., PMID:39294682
Endothelial Cell-Derived Soluble CD200 Determines the Ability of Immune Cells to Cross the Blood-Brain Barrier., PMID:39273210
Knockdown of type 2 orexin receptor in adult mouse testis potentiates testosterone production and germ cell proliferation., PMID:38866320
CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway., PMID:38692160
Selective Orexin 2 Receptor Blockade Alleviates Cognitive Impairments and the Pathological Progression of Alzheimer's Disease in 3xTg-AD Mice., PMID:38682858
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis., PMID:38396288
Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in human NSCLC., PMID:38354085
Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats., PMID:38237226
Different Transcriptome Features of Peripheral Blood Mononuclear Cells in Non-Emphysematous Chronic Obstructive Pulmonary Disease., PMID:38203236
PPAR-γ promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia., PMID:37971567
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice., PMID:37902837
Ferroptosis-related lncRNAs guiding osteosarcoma prognosis and immune microenvironment., PMID:37858131
Different mechanisms of CD200-CD200R induce diverse outcomes in cancer treatment., PMID:37734537
CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation., PMID:37391731
Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis., PMID:37291088
23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function., PMID:37288324
Single-cell RNA sequencing identifies a population of human liver-type ILC1s., PMID:36640314
CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation., PMID:36623588
The Presence of Psoriasis, Metabolic Syndrome and Their Combination Increases the Serum Levels of CRP and CD5L but Not sCD200R1 and sTLR2 in Participants., PMID:36556186
Phenotyping of M1 and M2a Macrophages and Differential Expression of ACE-2 on Monocytes by Flow Cytometry: Impact of Cell Culture Conditions and Sample Processing., PMID:36513932
Circulating CD200 is increased in the secretory phase of women with endometriosis as is endometrial mRNA, and endometrial stromal cell CD200R1 is increased in spite of reduced mRNA., PMID:36379046
Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer., PMID:36352147
Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4+ T Cells., PMID:36100367
Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker Discovery., PMID:36012423
Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients., PMID:35994639
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy., PMID:35867683
Reduced cutaneous CD200:CD200R1 signaling in psoriasis enhances neutrophil recruitment to skin., PMID:35759230
Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity., PMID:35743294
CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury., PMID:35681481
Pan-cancer analysis identifies CD300 molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia., PMID:35642341
Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice., PMID:35502705
Synthesis and characterization of a new Positron emission tomography probe for orexin 2 receptors neuroimaging., PMID:35397430
Can CD200R1 Agonists Slow the Progression of Osteoarthritis Secondary to Injury?, PMID:35359946
The Role of CD200-CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation., PMID:35326506
Altered expression of the immunoregulatory ligand-receptor pair CD200-CD200R1 in the brain of Parkinson's disease patients., PMID:35296683
CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells., PMID:35231818
MicroRNA-129-5p-regulated microglial expression of the surface receptor CD200R1 controls neuroinflammation., PMID:34952004
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties., PMID:34915155
Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets., PMID:34804946
For research use only. Not for human or drug use.
