Catalog No.
YME19101
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Lys348-Asn531
Predicted molecular weight
23.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q00342
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Flt3, FLK-2, Tyrosine-protein kinase receptor flk-2, CD135, Flt-3, FL cytokine receptor, FLT-3, Fetal liver kinase 2, Flk-2, Fms-like tyrosine kinase 3, Receptor-type tyrosine-protein kinase FLT3
In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system., PMID:40038600
Rational combinatorial targeting by adapter CAR-T-cells (AdCAR-T) prevents antigen escape in acute myeloid leukemia., PMID:39095503
Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy., PMID:38278496
Clinico-Radio-Pathologic Correlation of Leukostasis in Acute Myeloid Leukemia with FLT3 Mutation., PMID:37788644
Phase I study evaluating the Fc-optimized FLT3 antibody FLYSYN in AML patients with measurable residual disease., PMID:37587502
FLT3-directed UniCAR T-cell therapy of acute myeloid leukaemia., PMID:37460273
Targeting conditioned media dependencies and FLT-3 in chronic lymphocytic leukemia., PMID:37428863
In vitro culture of hematopoietic stem cell niche using angiopoietin-1-coupled alginate hydrogel., PMID:35489624
FLT3-ITD and CD135 Over-Expression are Frequent Findings of Poor Survival in Adult Patients with Acute Leukemias., PMID:33109387
Delineation of target expression profiles in CD34+/CD38- and CD34+/CD38+ stem and progenitor cells in AML and CML., PMID:33085758
FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation., PMID:32887750
Bendamustine Conditioning Skews Murine Host DCs Toward Pre-cDC1s and Reduces GvHD Independently of Batf3., PMID:32765499
NUP98-HOXA10hd fusion protein sustains multi-lineage haematopoiesis of lineage-committed progenitors in transplant setting., PMID:32725842
Simultaneous Detection of a Cluster of Differentiation Markers on Leukemia-Derived Exosomes by Multiplex Immuno-Polymerase Chain Reaction via Capillary Electrophoresis Analysis., PMID:32600030
Mesenchymal stem cells induced regulatory dendritic cells from hemopoietic progenitor cells through Notch pathway and TGF-β synergistically., PMID:32199868
γδ T Cells Number, CD200, and Flt3 Expression Is Associated with Higher Progression Free Survival in Patients with Chronic Myeloid Leukemia., PMID:32113783
Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia., PMID:31554356
Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation., PMID:31139183
Genetically engineered CAR NK cells display selective cytotoxicity against FLT3-positive B-ALL and inhibit in vivo leukemia growth., PMID:30860598
Impact of FLT3 Receptor (CD135) Detection by Flow Cytometry on Clinical Outcome of Adult Acute Myeloid Leukemia Patients., PMID:29907544
Phenotyping and Target Expression Profiling of CD34+/CD38- and CD34+/CD38+ Stem- and Progenitor cells in Acute Lymphoblastic Leukemia., PMID:29772458
Spotlight on midostaurin in the treatment of FLT3-mutated acute myeloid leukemia and systemic mastocytosis: design, development, and potential place in therapy., PMID:29343975
Immobilisation of Delta-like 1 ligand for the scalable and controlled manufacture of hematopoietic progenitor cells in a stirred bioreactor., PMID:28778182
Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group., PMID:28108543
Permissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment., PMID:27911806
Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences., PMID:27837108
In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions., PMID:27514809
A case of mistaken identity: CD11c-eYFP(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells., PMID:27189804
Isolation of Dendritic Cell Progenitor and Bone Marrow Progenitor Cells from Mouse., PMID:27142008
FLT3 (CD135) and Interleukin-2 receptor alpha-chain (CD25) expression in acute myeloid leukemia: improving the correspondence to FLT3 - internal tandem duplication mutation., PMID:27087256
Granulocytic myeloid-derived suppressor cells maintain feto-maternal tolerance by inducing Foxp3 expression in CD4+CD25-T cells by activation of the TGF-β/β-catenin pathway., PMID:27016139
Editorial: Flt3 ligand-friend or foe?, PMID:26932387
Novel anticancer compound [trifluoromethyl-substituted pyrazole N-nucleoside] inhibits FLT3 activity to induce differentiation in acute myeloid leukemia cells., PMID:26916980
Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia., PMID:26852660
Differential antigen expression and aberrant signaling via PI3/AKT, MAP/ERK, JAK/STAT, and Wnt/β catenin pathways in Lin-/CD38-/CD34+ cells in acute myeloid leukemia., PMID:26010294
Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers., PMID:25915810
Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors., PMID:24954893
Induction of osteoclast progenitors in inflammatory conditions: key to bone destruction in arthritis., PMID:24913769
Characterization of a resident population of adventitial macrophage progenitor cells in postnatal vasculature., PMID:24906644
Gr-1dimCD11b+ immature myeloid-derived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in mice., PMID:24711621
FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in rheumatoid arthritis., PMID:24314260
Increased coexpression of c-KIT and FLT3 receptors on myeloblasts: independent predictor of poor outcome in pediatric acute myeloid leukemia., PMID:23740774
The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial., PMID:23349309
A proteomics and transcriptomics approach to identify leukemic stem cell (LSC) markers., PMID:23233446
Hematopoietic stem and progenitor cell populations in MoMuLV-ts-1 induced lymphoma in a murine model., PMID:22981528
Present and future of tyrosine kinase inhibitors in renal cell carcinoma: analysis of hematologic toxicity., PMID:22630822
Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117., PMID:22355330
New perspectives: role of Sunitinib in breast cancer., PMID:21717054
The critical role of agrin in the hematopoietic stem cell niche., PMID:21653324
The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells., PMID:21630253
For research use only. Not for human or drug use.
