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Recombinant Human CLDN11 Protein, N-His-SUMO

Catalog #:   YHB23101 Specific References (152) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: O75508
Protein length: Val23-Arg82
Overview

Catalog No.

YHB23101

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Val23-Arg82

Predicted molecular weight

18.93 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

O75508

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Claudin-11, OTM, OSP, CLDN11, Oligodendrocyte-specific protein

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human CLDN11 protein
References

Claudins and Gastric Cancer: An Overview. PMID: 35053454

An inducible Cldn11-CreERT2 mouse line for selective targeting of lymphatic valves. PMID: 34338433

RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction. PMID: 35263212

Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma. PMID: 29747653

MALAT1 Maintains the Intestinal Mucosal Homeostasis in Crohn's Disease via the miR-146b-5p-CLDN11/NUMB Pathway. PMID: 33677577

Tight junction proteins at the blood-brain barrier: far more than claudin-5. PMID: 30734065

lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through miR-135b suppression to promote CLDN11 expression. PMID: 32119960

Transgene-mediated rescue of spermatogenesis in Cldn11-null mice. PMID: 22378758

De novo stop-loss variants in CLDN11 cause hypomyelinating leukodystrophy. PMID: 33313762

Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling. PMID: 29700355

Postnatal changes in the expression of claudin-11 in the testes and excurrent ducts of the domestic rabbit (Oryctolagus cuniculus domesticus). PMID: 20966426

Claudin 11 inter-sertoli tight junctions in the testis of the korean soft-shelled turtle (Pelodiscus maackii). PMID: 25761591

The Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell Carcinoma. PMID: 28743857

Expression of claudin-11 in canine prepubertal testes, and in canine adult testes showing normal spermatogenesis, impaired spermatogenesis, or testicular neoplasia. PMID: 32171971

Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells. PMID: 19956721

Evaluation of the Prognostic Relevance of Differential Claudin Gene Expression Highlights Claudin-4 as Being Suppressed by TGFβ1 Inhibitor in Colorectal Cancer. PMID: 35281827

MiR-205 suppressed the malignant behaviors of breast cancer cells by targeting CLDN11 via modulation of the epithelial-to-mesenchymal transition. PMID: 33971623

Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced Trabecular Bone Mass Caused by Decreased Osteoblast Functions. PMID: 35326428

Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells. PMID: 31551535

Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function. PMID: 19622796

Skin barrier damage after exposure to paraphenylenediamine. PMID: 31783056

Promoter CpG island hypermethylation in dysplastic nevus and melanoma: CLDN11 as an epigenetic biomarker for malignancy. PMID: 24999589

Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells. PMID: 22736761

Multi-Omics Analysis Reveals Myelin, Presynaptic and Nicotinate Alterations in the Hippocampus of G72/G30 Transgenic Mice. PMID: 35207732

Promoter methylation as biomarkers for diagnosis of melanoma: A systematic review and meta-analysis. PMID: 30370527

MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11. PMID: 28962204

Isolation and characterization of a novel oligodendrocyte-specific protein. PMID: 8797478

Genetic and epigenetic alteration in gastric carcinogenesis. PMID: 21054651

The antibody response to oligodendrocyte specific protein in multiple sclerosis. PMID: 20236710

Snail-induced claudin-11 prompts collective migration for tumour progression. PMID: 30664792

Kruppel-like factor 6 regulates Sertoli cell blood-testis barrier. PMID: 31136981

Disorganization of claudin-11 and dysfunction of the blood-testis barrier during puberty in a cryptorchid rat model. PMID: 32196966

Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. PMID: 10700007

T-cell responses to oligodendrocyte-specific protein in multiple sclerosis. PMID: 11746369

Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. PMID: 29632138

Spermatogonial stem cell transplantation into nonablated mouse recipient testes. PMID: 34143973

Adult sertoli cells are not terminally differentiated in the Djungarian hamster: effect of FSH on proliferation and junction protein organization. PMID: 16407497

Transcriptomic Profiling of Medial Temporal Lobe Epilepsy. PMID: 23483634

Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve. PMID: 18412169

Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patients. PMID: 16213148

Mutational analysis of the GATA4 gene in Chinese men with nonobstructive azoospermia. PMID: 32859868

Developmental expression of OSP/claudin-11. PMID: 10797530

Changes in Inflammatory Cytokines Accompany Deregulation of Claudin-11, Resulting in Inter-Sertoli Tight Junctions in Varicocele Rat Testes. PMID: 27164517

Glial-like differentiation potential of human mature adipocytes. PMID: 25007949

A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability. PMID: 33653920

In vitro effects of glyphosate and Roundup on Sertoli cell physiology. PMID: 31626902

Low Doses of Glyphosate/Roundup Alter Blood-Testis Barrier Integrity in Juvenile Rats. PMID: 33776912

Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome. PMID: 32802035

miR-99b promotes metastasis of hepatocellular carcinoma through inhibition of claudin 11 expression and may serve as a prognostic marker. PMID: 26134929

[Pathogenetic-clinical problems of Lyme borreliosis]. PMID: 14560706

Claudins 1, 11 and twist in meningiomas. PMID: 20546350

Regulation of testicular tight junctions by gonadotrophins in the adult Djungarian hamster in vivo. PMID: 18502899

Increased expression of dermatopontin and its implications for testicular dysfunction in mice. PMID: 26861869

Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo. PMID: 22268650

Characterization of inter-Sertoli cell tight and gap junctions in the testis of turtle: Protect the developing germ cells from an immune response. PMID: 29959039

Claudin expression during early postnatal development of the murine cochlea. PMID: 29368643

Claudin immunolocalization in neonatal mouse epithelial tissues. PMID: 17828607

Inhibition of claudin-11 and occludin expression in rat Sertoli cells by mono-(2-ethylhexyl) phthalate through p44/42 mitogen-activated protein kinase pathway. PMID: 21868750

Extracellular Vesicles Containing MicroRNA-92a-3p Facilitate Partial Endothelial-Mesenchymal Transition and Angiogenesis in Endothelial Cells. PMID: 31500278

Phenotyping the claudin 11 deficiency in testis: from histology to immunohistochemistry. PMID: 21874455

Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice. PMID: 33653651

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections. PMID: 28784969

A humoral response to oligodendrocyte-specific protein in MS: a potential molecular mimic. PMID: 10408552

T-cells specific for soluble recombinant oligodendrocyte-specific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2(b) and H-2(s) mice. PMID: 10713362

Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells. PMID: 30514158

Germ cell migration across Sertoli cell tight junctions. PMID: 22997133

Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis. PMID: 10919290

Immuno-Laser-Capture Microdissection for the Isolation of Enriched Glial Populations from Frozen Post-Mortem Human Brain. PMID: 29344867

Expression of claudin‑11 in a rat model of varicocele and its effects on the blood‑testis barrier. PMID: 30365105

Identification of Candidate Gene Signatures and Regulatory Networks in Endometriosis and its Related Infertility by Integrated Analysis. PMID: 34993929

Effect of mirabegron on tight junction molecules in primary cultured rat Sertoli cells. PMID: 30706522

Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis. PMID: 17945025

Expression pattern of testicular claudin-11 in infertile men. PMID: 22951003

Dermatopontin is a novel regulator of the CdCl2-induced decrease in claudin-11 expression. PMID: 24909373

Claudin-11 expression increased in spermatogenic defect in human testes. PMID: 20850723

Spatiotemporal loss of K+ transport proteins in the developing cochlear lateral wall of guinea pigs with hereditary deafness. PMID: 18093167

Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling. PMID: 31112308

An OMICS-based study of the role of C3dg in keratinocytes: RNA sequencing, antibody-chip array, and bioinformatics approaches. PMID: 30974145

Comprehensive analysis of expression and prognostic value of the claudin family in human breast cancer. PMID: 33714203

Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice. PMID: 29491447

Activin signaling regulates Sertoli cell differentiation and function. PMID: 23117933

Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma. PMID: 31115553

Highly Conserved Testicular Localization of Claudin-11 in Normal and Impaired Spermatogenesis. PMID: 27486954

Epitope specificity of autoreactive T and B cells associated with experimental autoimmune encephalomyelitis and optic neuritis induced by oligodendrocyte-specific protein in SJL/J mice. PMID: 17082656

Identification of claudin-2, -6, -11 and -14 as prognostic markers in human breast carcinoma. PMID: 31934042

Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma. PMID: 23590314

Wt1 deficiency causes undifferentiated spermatogonia accumulation and meiotic progression disruption in neonatal mice. PMID: 24129152

Transcriptional activity of an ovarian-specific promoter from rat in dairy goat granulosa cells. PMID: 23408398

Pharmacological inhibition of spinal cord injury-stimulated ribosomal biogenesis does not affect locomotor outcome. PMID: 28188847

Expression of Oligodendrocyte Marker during Peripheral-Central Transitional Zone Formation of the Postnatal Mouse Cochlear Nerve. PMID: 28695768

Sertoli cell-specific ablation of miR-17-92 cluster significantly alters whole testis transcriptome without apparent phenotypic effects. PMID: 29795630

The mRNA of claudins is expressed in the endolymphatic sac epithelia. PMID: 21871748

miR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3. PMID: 37014739

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development. PMID: 21152390

Notch signaling regulates nuclear androgen receptor AR and membrane androgen receptor ZIP9 in mouse Sertoli cells. PMID: 31468707

Gonadotropins regulate rat testicular tight junctions in vivo. PMID: 20357222

Claudin-11 decreases the invasiveness of bladder cancer cells. PMID: 21468549

COVID-19 disrupts the blood-testis barrier through the induction of inflammatory cytokines and disruption of junctional proteins. PMID: 34436630

miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin. PMID: 22521588

Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily. PMID: 15211584

Integration of metabolomics and transcriptomics to reveal ferroptosis is involved in Tripterygium wilfordii polyglycoside tablet-induced testicular injury. PMID: 36539070

Androgen initiates Sertoli cell tight junction formation in the hypogonadal (hpg) mouse. PMID: 22623623

Gene expression profile in heat-shocked Holstein and Nelore oocytes and cumulus cells. PMID: 27802411

Towards the early detection of ductal carcinoma (a common type of breast cancer) using biomarkers linked to the PPAR(γ) signaling pathway. PMID: 31902979

Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro. PMID: 26585695

Immunohistochemical Characterization of Spontaneous Sertoli Cell Clusters in the Seminiferous Tubules of C57BL/6J Mice. PMID: 25630681

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. PMID: 24916269

Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and Lack Strong Adhesive Properties. PMID: 26445439

A role for Sec8 in oligodendrocyte morphological differentiation. PMID: 16478790

Identification of genome-wide targets of Olig2 in the adult mouse spinal cord using ChIP-Seq. PMID: 29049317

Fsh controls gene expression in fish both independently of and through steroid mediation. PMID: 24194844

Targeting T cells responsive to the priming epitope prevent the relapsing phase of experimental autoimmune encephalomyelitis. PMID: 23611642

DNA methylation profiling in different phases of temporomandibular joint osteoarthritis in rats. PMID: 27127843

Advantages of pulsatile hormone treatment for assessing hormone-induced gene expression by cultured rat Sertoli cells. PMID: 27139181

Contemporaneous effects of diabetes mellitus and hypothyroidism on spermatogenesis and immunolocalization of Claudin-11 inside the seminiferous tubules of mice. PMID: 29940839

Novel pharmacologic targeting of tight junctions and focal adhesions in prostate cancer cells. PMID: 24497940

Tight junctions potentiate the insulative properties of small CNS myelinated axons. PMID: 19047465

A novel subcellular machine contributes to basal junction remodeling in the seminiferous epithelium. PMID: 23303684

Molecular dynamics of the blood-testis barrier components during murine spermatogenesis. PMID: 20578065

Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis. PMID: 27974247

White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease. PMID: 26844268

Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling. PMID: 26242735

In Vitro Evaluation of Damage by Heavy Metals in Tight and Gap Junctions of Sertoli Cells. PMID: 28829631

High glucose decreases claudins-5 and -11 in cardiac microvascular endothelial cells: Antagonistic effects of tongxinluo. PMID: 27111519

Neurobehavioral and cytotoxic effects of vanadium during oligodendrocyte maturation: a protective role for erythropoietin. PMID: 24927405

Temporal role of Sertoli cell androgen receptor expression in spermatogenic development. PMID: 23160479

Expression of claudin-11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ. PMID: 27992079

Differential expression of claudin tight junction proteins in the human cortical nephron. PMID: 20124215

Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type. PMID: 27518164

Using the Allen gene expression atlas of the adult mouse brain to gain further insight into the physiological significance of TAG-1/Contactin-2. PMID: 32601750

K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development. PMID: 16624990

Selective Neural Deletion of the Atg7 Gene Reduces Irradiation-Induced Cerebellar White Matter Injury in the Juvenile Mouse Brain by Ameliorating Oligodendrocyte Progenitor Cell Loss. PMID: 31213984

A novel scoring system for gastric cancer risk assessment based on the expression of three CLIP4 DNA methylation-associated genes. PMID: 29901187

Effects of low doses of carbendazim or iprodione either separately or in mixture on the pubertal rat seminiferous epithelium: An ex vivo study. PMID: 28576679

CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. PMID: 10612400

Early effects of Sertoli cell-selective androgen receptor ablation on testicular gene expression. PMID: 19392831

Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. PMID: 18357522

Experimental Cryptorchidism Causes Chronic Inflammation and a Progressive Decline in Sertoli Cell and Leydig Cell Function in the Adult Rat Testis. PMID: 34008157

Pediococcus pentosaceus xy46 Can Absorb Zearalenone and Alleviate its Toxicity to the Reproductive Systems of Male Mice. PMID: 31426404

Expression of claudin-11, -23 in different gastric tissues and its relationship with the risk and prognosis of gastric cancer. PMID: 28350854

Genome-Wide Interaction Study of Omega-3 PUFAs and Other Fatty Acids on Inflammatory Biomarkers of Cardiovascular Health in the Framingham Heart Study. PMID: 28820441

Zona occludens-2 is critical for blood-testis barrier integrity and male fertility. PMID: 19692573

Claudin expression in the bone-lining cells of female rats exposed to long-standing acidemia. PMID: 20035748

Fertility Preservation in Childhood Cancer: Endocrine Activity in Prepubertal Human Testis Xenografts Exposed to a Pubertal Hormone Environment. PMID: 33008013

Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fibroblasts. PMID: 16311016

Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis. PMID: 19741204

Male reproductive toxicity of CrVI: In-utero exposure to CrVI at the critical window of testis differentiation represses the expression of Sertoli cell tight junction proteins and hormone receptors in adult F1 progeny rats. PMID: 28192182

Leukocyte Gene Expression and Plasma Concentration in Multiple Sclerosis: Alteration of Transforming Growth Factor-βs, Claudin-11, and Matrix Metalloproteinase-2. PMID: 26768647

Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus. PMID: 17804490

Cloning and expression of P67 protein of Mycoplasma leachii. PMID: 29062201

Enhanced hydrolysis of lignocellulosic biomass with doping of a highly thermostable recombinant laccase. PMID: 31260768

Production of an Antibody Fragment (scFv) Targeting PcrV Protein of Pseudomonas aeruginosa in Fed-Batch Cultivation Mode. PMID: 34641643

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human CLDN11 Protein, N-His-SUMO [YHB23101]
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