Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis. PMID: 32726800
CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity. PMID: 33785592
C5a receptor (CD88) blockade protects against MPO-ANCA GN. PMID: 24179165
Overexpression of CD88 predicts poor prognosis in non-small-cell lung cancer. PMID: 23706417
C5aR2 receptor: The genomic twin of the flamboyant C5aR1. PMID: 35977039
Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells. PMID: 25769922
Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects. PMID: 29327939
Guhong Injection Prevents Ischemic Stroke-Induced Neuro-Inflammation and Neuron Loss Through Regulation of C5ar1. PMID: 35387346
Complement and blood-brain barrier integrity. PMID: 25041699
Avacopan for the treatment of ANCA-associated vasculitis. PMID: 34006155
The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity. PMID: 31160390
Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology. PMID: 23394121
A Potential Link between the C5a Receptor 1 and the β1-Adrenoreceptor in the Mouse Heart. PMID: 26727203
Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways. PMID: 28690033
A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA. PMID: 25917104
Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2. PMID: 36565188
Structural sequence evolution and computational modeling approaches of the complement system in leishmaniasis. PMID: 32085887
Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling. PMID: 35144762
Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients. PMID: 32983087
Inhibiting the C5-C5a receptor axis. PMID: 21549429
PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. PMID: 21441599
Avacopan for the treatment of ANCA-associated vasculitis: an update. PMID: 36545762
The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases. PMID: 22964232
C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. PMID: 22691190
C5L2: a controversial receptor of complement anaphylatoxin, C5a. PMID: 23239822
C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages. PMID: 32611725
Early expression changes of complement regulatory proteins and C5A receptor (CD88) on leukocytes after multiple injury in humans. PMID: 19864971
Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model. PMID: 34867198
The Role of C5a Receptor Signaling in Endotoxin-Induced Miscarriage and Preterm Birth. PMID: 25846074
Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67. PMID: 32233506
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727. PMID: 29300009
Complement C5A regulates prolabor mediators in human placenta. PMID: 22441801
Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5. PMID: 27105526
Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study. PMID: 29915941
Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies against Encapsulated Protein Antigen in Young Naïve Mice after Respiratory Immunization. PMID: 36145590
Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. PMID: 25446428
C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. PMID: 19324972
C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts. PMID: 28033061
Activation of basophils is a new and sensitive marker of biocompatibility in hemodialysis. PMID: 24712758
Prostate cancer C5a receptor expression and augmentation of cancer cell proliferation, invasion, and PD-L1 expression by C5a. PMID: 33368414
Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness. PMID: 25050844
Tenocyte activation and regulation of complement factors in response to in vitro cell injury. PMID: 24732065
High expression of C5L2 correlates with high proinflammatory cytokine expression in advanced human atherosclerotic plaques. PMID: 24819959
TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2. PMID: 21630250
Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease. PMID: 19077082
Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy. PMID: 30260475
C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation. PMID: 19265162
Neutrophil Receptor Response to Bacterial N-formyl Peptides is Similar in Term Newborn Infants and Adults in Contrast to IL-8. PMID: 27606963
Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway. PMID: 22496247
The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation. PMID: 16879222
Differential expression of the C5a receptor and complement receptors 1 and 3 after LPS stimulation of neutrophils and monocytes. PMID: 15541042
Urokinase-induced activation of the gp130/Tyk2/Stat3 pathway mediates a pro-inflammatory effect in human mesangial cells via expression of the anaphylatoxin C5a receptor. PMID: 15944400
C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance., PMID:40484643
Inhibition of Alternative and Terminal Complement Pathway Components Modulate the Immune Response Against Bacteria and Fungi in Whole Blood., PMID:40387159
An antibody-dependent cellular phagocytosis-related gene signature predicts survival and response to immunotherapy in stomach adenocarcinoma., PMID:40193680
C5aR1 Promotes Invasion, Metastasis, and Poor Prognosis in Cutaneous Squamous Cell Carcinoma., PMID:40056975
Establishment of a prediction model and immune infiltration characteristics of atherosclerosis progression based on neutrophil extracellular traps-related genes., PMID:40053030
Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis., PMID:39984108
The role of the C5a-C5aR pathway in iron metabolism and gastric cancer progression., PMID:39850877
The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome., PMID:39848404
KLHDC8A knockdown in normal ovarian epithelial cells promoted the polarization of pro-tumoral macrophages via the C5a/C5aR/p65 NFκB signaling pathway., PMID:39805213
Dapsone Alters Phenotypical and Functional Properties of Human Neutrophils In Vitro., PMID:39795170
Toxin protein LukS-PV targeting complement receptor C5aR1 inhibits cell proliferation in hepatocellular carcinoma via the HDAC7-Wnt/β-catenin axis., PMID:39736396
The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1., PMID:39679722
The C5a/C5aR1 Axis Promotes Migration of Tolerogenic Dendritic Cells to Lymph Nodes, Impairing the Anticancer Immune Response., PMID:39666368
C5aR expression in kidney tubules, macrophages and fibrosis., PMID:39607065
C3a Mediates Endothelial Barrier Disruption in Brain-Derived, but Not Retinal, Human Endothelial Cells., PMID:39457022
Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4., PMID:39368999
Complement component 5a receptor 1 and leukotriene B4 receptor 1 regulate neutrophil extracellular trap (NET) formation through Rap1a/B-Raf/ERK signaling pathway and their deficiency in term low birth weight newborns leads to deficient NETosis., PMID:39303536
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus., PMID:39297970
Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy., PMID:39153560
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1., PMID:39145459
The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH., PMID:39060563
Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axis., PMID:39055717
Structure of Designer Antibody-like Peptides Binding to the Human C5a with Potential to Modulate the C5a Receptor Signaling., PMID:39051153
Complement C3a/C3aR and C5a/C5aR deposits accelerate the progression of advanced IgA nephropathy to end-stage renal disease., PMID:38951265
C5AR1-induced TLR1/2 pathway activation drives proliferation and metastasis in anaplastic thyroid cancer., PMID:38934768
C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis., PMID:38458648
C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis., PMID:38449312
Semaglutide modulates prothrombotic and atherosclerotic mechanisms, associated with epicardial fat, neutrophils and endothelial cells network., PMID:38172989
Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients., PMID:38101498
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8+ T cell activity., PMID:38098230
Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody., PMID:37952515
The C5aR1 complement receptor: A novel immunomodulator of insulin action in skeletal muscle., PMID:37890688
C5a enhances Vδ1 T cells recruitment via the CCL2-CCR2 axis in IgA nephropathy., PMID:37862725
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1., PMID:37824211
PLK3 promotes the proneural-mesenchymal transition in glioblastoma via transcriptional regulation of C5AR1., PMID:37568042
LPS-induced inflammation potentiates dental pulp stem cell odontogenic differentiation through C5aR and p38., PMID:37247252
Anaphylatoxin C5a receptor signaling induces mitochondrial fusion and sensitizes retinal pigment epithelial cells to oxidative stress., PMID:37187450
CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes., PMID:36946983
Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages., PMID:36882040
Complement receptor C5aR1 blockade reprograms tumor-associated macrophages and synergizes with anti-PD-1 therapy in gastric cancer., PMID:36799619
Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine., PMID:36773726
Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2., PMID:36565188
Avacopan for the treatment of ANCA-associated vasculitis: an update., PMID:36545762
C5aR1 shapes a non-inflammatory tumor microenvironment and mediates immune evasion in gastric cancer., PMID:36508191
Cancer cell-derived type I interferons instruct tumor monocyte polarization., PMID:36476866
AVACOPAN: A New Adjunctive Therapy for Antineutrophil Cytoplasmic Antibody-Associated Vasculitis., PMID:36469359
Differential expression of immune-regulatory proteins C5AR1, CLEC4A and NLRP3 on peripheral blood mononuclear cells in early-stage non-small cell lung cancer patients., PMID:36323738
Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients., PMID:36232539
C5aR1 promotes the progression of colorectal cancer by EMT and activating Wnt/β-catenin pathway., PMID:36192575
Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies against Encapsulated Protein Antigen in Young Naïve Mice after Respiratory Immunization., PMID:36145590
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