Catalog No.
PHE19301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ACVR1B (Ser24-Glu126).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Activin receptor-like kinase 4,SKR2,ACVRLK4,ACVR1B,ALK-4,Activin receptor type IB,Activin receptor type-1B,Serine/threonine-protein kinase receptor R2,ACTR-IB,ALK4
Purification
Purified by antigen affinity column.
Accession
P36896
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Cripto-1 acts as a molecular bridge linking nodal to ALK4 via distinct structural domains., PMID:39840816
ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders., PMID:33586684
Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma., PMID:33457096
Discovery and Validation of Serum Autoantibodies Against Tumor-Associated Antigens as Biomarkers in Gastric Adenocarcinoma Based on the Focused Protein Arrays., PMID:33346593
CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress., PMID:33187540
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop., PMID:32515349
Development of conformational antibodies targeting Cripto-1 with neutralizing effects in vitro., PMID:30703478
Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways., PMID:30061637
Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation., PMID:26484579
Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β., PMID:25707005
Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development., PMID:23342175
Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling., PMID:22267736
The proregion of mouse BMP15 regulates the cooperative interactions of BMP15 and GDF9., PMID:18633140
Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors., PMID:15459392
Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo., PMID:12925698
Immunocytochemical study of activin type IB receptor (XALK4) in Xenopus oocytes., PMID:12752499
A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src., PMID:12649175
For research use only. Not for human or drug use.
