Social stress induces neurovascular pathology promoting depression. PMID: 29184215
Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease. PMID: 35332151
Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5). PMID: 33280500
SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression. PMID: 36129989
Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression. PMID: 31974313
Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles. PMID: 32350344
JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function. PMID: 32673519
Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury. PMID: 33067719
Tight junction proteins at the blood-brain barrier: far more than claudin-5. PMID: 30734065
Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform. PMID: 28445614
Angelica sinensis polysaccharide improves rheumatoid arthritis by modifying the expression of intestinal Cldn5, Slit3 and Rgs18 through gut microbiota. PMID: 35318077
Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline. PMID: 33838873
Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF-Resistant Diabetic Macular Edema. PMID: 32139595
CLDN5 affects lncRNAs acting as ceRNA dynamics contributing to regulating blood‑brain barrier permeability in tumor brain metastasis. PMID: 29328410
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. PMID: 25753039
Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia. PMID: 35714222
Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. PMID: 27957319
Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression. PMID: 33383868
TNF-alpha induced NFκB signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells. PMID: 22138107
Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury. PMID: 20525806
Impact of the Endothelial Tight Junction Protein Claudin-5 on Clinical Profiles of Patients With COPD. PMID: 30088372
The CLDN5 gene at the blood-brain barrier in health and disease. PMID: 36978081
A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. PMID: 19111869
Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease. PMID: 33068684
Super-resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement. PMID: 34156149
Effect of bevacizumab on the tight junction proteins of vascular endothelial cells. PMID: 31632528
AKT2 maintains brain endothelial claudin-5 expression and selective activation of IR/AKT2/FOXO1-signaling reverses barrier dysfunction. PMID: 30574832
The CLDN5 locus may be involved in the vulnerability to schizophrenia. PMID: 15363474
Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells. PMID: 24522189
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis. PMID: 35338345
Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood-Brain Barrier Tight Junctions. PMID: 35816296
Further study of a genetic association between the CLDN5 locus and schizophrenia. PMID: 15820333
β1-integrin/matrix interactions support blood-brain barrier integrity. PMID: 21772311
The impact of pathogenic and artificial mutations on Claudin-5 selectivity from molecular dynamics simulations. PMID: 37138900
A weak association of the CLDN5 locus with schizophrenia in Chinese case-control samples. PMID: 20452046
Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke. PMID: 28490769
Tight Junction-Related CLDN5 and CLDN6 Genes, and Gap Junction-Related GJB6 and GJB7 Genes Are Somatically Mutated in Gastric and Colorectal Cancers. PMID: 32170581
Inner Blood-Retinal Barrier Regulation in Retinopathies. PMID: 31884633
The region-selective regulation of endothelial claudin-5 expression and signaling in brain health and disorders. PMID: 33694168
Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. PMID: 36058416
SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells. PMID: 28888043
Lowering of brain endothelial cell barrier function by exposure to 4'-iodo-α-pyrrolidinononanophenone. PMID: 35872046
Claudin-5a knockdown attenuates blood-neural barrier in zebrafish. PMID: 34500089
Epigenomics of idiopathic pulmonary fibrosis: evaluating the first steps. PMID: 22984022
Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5. PMID: 29849184
LPS-induced Acute Lung Injury Involves NF-κB-mediated Downregulation of SOX18. PMID: 29115856
Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF. PMID: 24515951
Expression of claudins relates to tumour aggressivity, location and recurrence in ependymomas. PMID: 23423606
[Peripheral neuropathy and blood-nerve barrier]. PMID: 20030260
A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. PMID: 16181776
Inflammation and Blood-Brain Barrier in Depression: Interaction of CLDN5 and IL6 Gene Variants in Stress-Induced Depression. PMID: 36472886
Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17. PMID: 37095509
Absence of MCP-induced Protein 1 Enhances Blood-Brain Barrier Breakdown after Experimental Stroke in Mice. PMID: 31261992
Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia. PMID: 18797402
ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. PMID: 22235125
Cisatracurium attenuates LPS-induced modulation of MMP3 and junctional protein expression in human microvascular endothelial cells. PMID: 33627570
Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. PMID: 19571261
Serum Claudin-5, but not Zonulin, May Be Associated with Obsessive-Compulsive Disorder. PMID: 35772137
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine. PMID: 20728510
Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells. PMID: 32759214
Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments. PMID: 24478310
Junctional protein regulation by sphingosine kinase 2 contributes to blood-brain barrier protection in hypoxic preconditioning-induced cerebral ischemic tolerance. PMID: 22314269
Claudin reduction may relate to an impaired skin barrier in rosacea. PMID: 30714633
Sphingosine-1-phosphate protects against brain microvascular endothelial junctional protein disorganization and barrier dysfunction caused by alcohol. PMID: 30281888
Astrocytes and pericytes attenuate severely injured patient plasma mediated expression of tight junction proteins in endothelial cells. PMID: 35789221
Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain. PMID: 29421550
Claudin-5 regulates blood-brain barrier permeability by modifying brain microvascular endothelial cell proliferation, migration, and adhesion to prevent lung cancer metastasis. PMID: 28961379
Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus. PMID: 18602987
Relationship between blood-brain permeability and antibodies against aquaporins in neuromyelitis optica spectrum disorders and multiple sclerosis patients. PMID: 35029294
Ethanol-induced lymphatic endothelial cell permeability via MAP-kinase regulation. PMID: 33909502
α(2)-adrenoceptors do not mediate neuroprotection in acute ischemic stroke in mice. PMID: 21792243
Brain endothelial dysfunction in cerebral adrenoleukodystrophy. PMID: 26377633
Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial claudin-5 and its modulation of cerebral vascular permeability. PMID: 27095710
Reversible inhibition of the blood-testis barrier protein improves stem cell homing in mouse testes. PMID: 30175719
Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury. PMID: 32684835
Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner. PMID: 35861713
Holey barrier: claudins and the regulation of brain endothelial permeability. PMID: 12743096
9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5. PMID: 34391839
Identification and dynamic regulation of tight junction protein expression in human neural stem cells. PMID: 25892136
Claudin-5 relieves cognitive decline in Alzheimer's disease mice through suppression of inhibitory GABAergic neurotransmission. PMID: 35471411
The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program. PMID: 30892142
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy. PMID: 31391341
Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells. PMID: 22333621
Whole-Genome Profiles of Malay Colorectal Cancer Patients with Intact MMR Proteins. PMID: 34573430
Lactation diminishes lesion-induced permeability of tracers into the brain. PMID: 30502400
ETB receptor-mediated MMP-9 activation induces vasogenic edema via ZO-1 protein degradation following status epilepticus. PMID: 26232046
Relationship of Cx43 regulation of vascular permeability to osteopontin-tight junction protein pathway after sepsis in rats. PMID: 28978514
Effect of γ-irradiation on expression of tight and adherens junction protein mRNA on in vitro blood-brain barrier model. PMID: 25408523
Paracellular barrier and tight junction protein expression in the immortalized brain endothelial cell lines bEND.3, bEND.5 and mouse brain endothelial cell 4. PMID: 23449334
Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization. PMID: 35476363
Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke. PMID: 30504279
Low-Dose X-Ray Increases Paracellular Permeability of Human Renal Glomerular Endothelial Cells. PMID: 36267304
Blood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study. PMID: 36337080
[The Endothelin ETB Receptor Antagonist BQ788 Protects against Brain Edema after Fluid Percussion Injury by Decreasing Vascular Endothelial Growth Factor-A Expression in Mice]. PMID: 28966265
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. PMID: 32897857
HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells. PMID: 14515355
Serum levels of endocan, claudin-5 and cytokines in migraine. PMID: 27010153
Down regulated expression of Claudin-1 and Claudin-5 and up regulation of β-catenin: association with human glioma progression. PMID: 25345514
Zonulin and claudin-5 levels in multisystem inflammatory syndrome and SARS-CoV-2 infection in children. PMID: 35638118
Claudin expression and tight junction protein localization in the lining epithelium of the keratocystic odontogenic tumors, dentigerous cysts, and radicular cysts. PMID: 23601220
Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells. PMID: 17169347
Serum zonulin and claudin-5 levels in children with obsessive-compulsive disorder. PMID: 31961248
Hypoxic glioblastoma release exosomal VEGF-A induce the permeability of blood-brain barrier. PMID: 29787762
Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma. PMID: 17981296
Claudin expression in breast tumors. PMID: 16084960
Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin. PMID: 31825142
Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo. PMID: 27240521
Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells. PMID: 20139322
Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PMID: 27504984
Ocular manifestations of 22q11.2 microduplication. PMID: 23972321
GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. PMID: 31582413
Regulation of heterotypic claudin compatibility. PMID: 17699514
Appearance of claudin-5+ leukocyte subtypes in the blood and CNS during progression of EAE. PMID: 34933669
Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo. PMID: 17931362
Changes in the phosphorylation of claudins during the course of experimental colitis. PMID: 26722407
Transepithelial leak in Barrett's esophagus. PMID: 17103306
Claudin-5 as a novel estrogen target in vascular endothelium. PMID: 19910637
An ECV304 monoculture model for permeability assessment of blood-brain barrier. PMID: 29100486
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