Catalog No.
YHG89001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala7-Arg61
Predicted molecular weight
34.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14739
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LMN2R, LBR, C14SR, Integral nuclear envelope inner membrane protein, Sterol C14-reductase, 3-beta-hydroxysterol Delta (14)-reductase, Delta(14)-sterol reductase LBR, Lamin-B receptor, Delta-14-SR, C-14 sterol reductase
Evenly Distributed Protein Intake over 3 Meals Augments Resistance Exercise-Induced Muscle Hypertrophy in Healthy Young Men. PMID: 32321161
Deletion of LBR N-terminal domains recapitulates Pelger-Huet anomaly phenotypes in mouse without disrupting X chromosome inactivation. PMID: 33846535
SR Protein Kinase 1 Inhibition by TAF15. PMID: 36611919
Progress toward understanding chromosome silencing by Xist RNA. PMID: 32482714
Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy. PMID: 30969503
Lamin B Receptor: Interplay between Structure, Function and Localization. PMID: 28858257
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. PMID: 33296701
From LBR-101 to Fremanezumab for Migraine. PMID: 30311143
SRPK1 and LBR protein kinases show identical substrate specificities. PMID: 10049757
Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. PMID: 9169472
Fremanezumab. PMID: 30371997
Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker. PMID: 10828963
LBR, a chromatin and lamin binding protein from the inner nuclear membrane, is proteolyzed at late stages of apoptosis. PMID: 9570761
Expanding the genetic architecture and phenotypic spectrum in the skeletal ciliopathies. PMID: 29068549
Effect of antithyroid antibodies on women with recurrent miscarriage: A meta-analysis. PMID: 32198952
Efficacy and Safety of Masitinib in Progressive Forms of Multiple Sclerosis: A Randomized, Phase 3, Clinical Trial. PMID: 35190477
Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1. PMID: 11571267
Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane. PMID: 8157663
Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. PMID: 33112418
Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells. PMID: 30615890
Methodologies to monitor protein turnover at the inner nuclear membrane. PMID: 30910029
A common pathomechanism in GMAP-210- and LBR-related diseases. PMID: 30518689
GnRH agonist and hCG (dual trigger) versus hCG trigger for follicular maturation: a systematic review and meta-analysis of randomized trials. PMID: 34059045
Pelger-Huët anomaly and Greenberg skeletal dysplasia: LBR-associated diseases of cholesterol metabolism. PMID: 27830109
Dynamics and Structure-Function Relationships of the Lamin B Receptor (LBR). PMID: 28118363
Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis. PMID: 36124691
Identification of ligand-binding residues using protein sequence profile alignment and query-specific support vector machine model. PMID: 32622978
ELYS regulates the localization of LBR by modulating its phosphorylation state. PMID: 27802161
Bi-allelic loss-of-function variants in TMEM147 cause moderate to profound intellectual disability with facial dysmorphism and pseudo-Pelger-Huët anomaly. PMID: 36044892
Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. PMID: 8157662
Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse. PMID: 36000704
Early Treatment with Pegylated Interferon Lambda for Covid-19. PMID: 36780676
Dosage effect of zero to three functional LBR-genes in vivo and in vitro. PMID: 21326950
The danger of "multi-tasking": LBR out of control. PMID: 21327079
Velcro in the nuclear envelope: LBR and LAPs. PMID: 9883877
Nuclear assembly. PMID: 9442884
[Analysis of LBR gene mutation in a pedigree affected with Pelger-Huёt anomaly]. PMID: 31515787
Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR. PMID: 8550049
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. PMID: 25915022
Nuclear envelope protein autoantibodies in primary biliary cirrhosis. PMID: 9089913
Antenatal diagnostic dilemma in a pseudodominant pedigree with lamin-B receptor (LBR)-related regressive spondylometaphyseal dysplasia. PMID: 34467646
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. PMID: 23374351
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis. PMID: 36096534
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. PMID: 33958580
Phosphorylation Promotes the Accumulation of PERIOD Protein Foci. PMID: 37223461
Efficacy of three COS protocols and predictability of AMH and AFC in women with discordant ovarian reserve markers: a retrospective study on 19,239 patients. PMID: 34454544
Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization. PMID: 8838815
Laminopathies and lamin-associated signaling pathways. PMID: 21400569
LBR mutation and nuclear envelope defects in a patient affected with Reynolds syndrome. PMID: 20522425
Ligand-Enhanced Negative Images Optimized for Docking Rescoring. PMID: 35887220
The nuclear lamina in health and disease. PMID: 27158763
Genetic architecture of band neutrophil fraction in Iceland. PMID: 35650273
Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally. PMID: 31911440
Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program. PMID: 24366980
A novel case of Greenberg dysplasia and genotype-phenotype correlation analysis for LBR pathogenic variants: An instructive example of one gene-multiple phenotypes. PMID: 30561119
CTCF supports preferentially short lamina-associated domains. PMID: 35239049
Temporal differences in the appearance of NEP-B78 and an LBR-like protein during Xenopus nuclear envelope reassembly reflect the ordered recruitment of functionally discrete vesicle types. PMID: 9922450
Colocalization of vertebrate lamin B and lamin B receptor (LBR) in nuclear envelopes and in LBR-induced membrane stacks of the yeast Saccharomyces cerevisiae. PMID: 7937849
Fremanezumab for the preventive treatment of migraine in adults. PMID: 31220963
Understanding and recognizing the Pelger-Huët anomaly. PMID: 22338047
Nuclear envelope protein autoantigens in primary biliary cirrhosis. PMID: 17931195
Lamin B receptor: multi-tasking at the nuclear envelope. PMID: 21327105
Aberrant localization of lamin B receptor (LBR) in cellular senescence in human cells. PMID: 27059139
Molecular cloning, expression, and characterization of a putative activation-associated secreted protein from Angiostrongylus cantonensis. PMID: 23192529
LMNA, ZMPSTE24, and LBR are not mutated in scleroderma. PMID: 19645629
Lipid--protein interactions in bacteriorhodopsin--dimyristoylphosphatidylcholine vesicles. PMID: 7213618
Anti-CGRP monoclonal antibodies in migraine: current perspectives. PMID: 27339365
Characterization of lamin B receptor of Sf9 cells and its fate during Autographa californica nucleopolyhedrovirus infection. PMID: 32246222
Pelger-huet anomaly and a mild skeletal phenotype secondary to mutations in LBR. PMID: 23824842
Intramuscular injection of human chorionic gonadotropin prior to secretory transformation in patients undergoing frozen-thawed embryo transfer cycles. PMID: 32450894
Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane. PMID: 26056139
Untargeted Metabolomics Profiling of Arabidopsis WT, lbr-2-2 and bak1-4 Mutants Following Treatment with Two LPS Chemotypes. PMID: 35629883
Nuclear envelope dynamics during mammalian spermatogenesis: new insights on male fertility. PMID: 30701647
The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. PMID: 9003786
Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. PMID: 8663349
Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit. PMID: 20576617
Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane. PMID: 7790369
[Nuclear abnormalities in Pelger-Huet anomaly; progress in blood cell morphology]. PMID: 15724491
KSHV ORF67 encoded lytic protein localizes on the nuclear membrane and alters emerin distribution. PMID: 23623980
Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence. PMID: 29415520
Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation. PMID: 22581323
The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. PMID: 27336722
Knock-down of methyl CpG-binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells. PMID: 22783988
The nuclear lamina: molecular organization and interaction with chromatin. PMID: 10651245
The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). PMID: 32126237
Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. PMID: 31825172
The granulocyte nucleus and lamin B receptor: avoiding the ovoid. PMID: 17245605
Cardiovascular and hemodynamic parameters in women following prolonged CGRP inhibition using LBR-101, a monoclonal antibody against CGRP. PMID: 24662322
Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein. PMID: 21327084
Remodeling the sperm nucleus into a male pronucleus at fertilization. PMID: 10732122
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney. PMID: 36454702
The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase. PMID: 1326541
Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging. PMID: 32726434
Formation of the sea urchin male pronucleus in cell-free extracts. PMID: 10824981
An anadysplasia-like, spontaneously remitting spondylometaphyseal dysplasia secondary to lamin B receptor (LBR) gene mutations: further definition of the phenotypic heterogeneity of LBR-bone dysplasias. PMID: 25348816
SRPK1 and Akt Protein Kinases Phosphorylate the RS Domain of Lamin B Receptor with Distinct Specificity: A Combined Biochemical and In Silico Approach. PMID: 27105349
Autoantigens of the nuclear pore complex. PMID: 15175862
Inner nuclear membrane proteins: functions and targeting. PMID: 11766875
For research use only. Not for human or drug use.
