Catalog No.
YHK89801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro253-Gln316
Predicted molecular weight
35.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRM0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GLUT-9, SLC2A9, Glucose transporter type 9, Solute carrier family 2, facilitated glucose transporter member 9, Urate transporter, GLUT9
Uric acid transport and disease. PMID: 20516647
The biology of urate. PMID: 32620198
The molecular physiology of uric acid homeostasis. PMID: 25422986
The Role of the Intestine in the Development of Hyperuricemia. PMID: 35281005
Mouse models for human hyperuricaemia: a critical review. PMID: 31118497
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. PMID: 33762358
Dietary Fructose Promotes Prostate Cancer Growth. PMID: 24409316
Expression of SLC2A9 isoforms in the kidney and their localization in polarized epithelial cells. PMID: 26167684
SLC2A9 Genotype Is Associated with SLC2A9 Gene Expression and Urinary Uric Acid Concentration. PMID: 18842065
SLC2A9 is a high-capacity urate transporter in humans. PMID: 36745138
Genetic and Epigenetic Regulation of the Innate Immune Response to Gout. PMID: 32488095
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion. PMID: 27052299
Associations between SLC2A9 polymorphisms and gout susceptibility : A meta-analysis. PMID: 29523220
Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells. PMID: 33075645
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase. PMID: 27255295
Association between SLC2A9 (GLUT9) gene polymorphisms and gout susceptibility: an updated meta-analysis. PMID: 30427222
SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1. PMID: 32258131
Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis. PMID: 34444825
Impact of Camellia japonica Bee Pollen Polyphenols on Hyperuricemia and Gut Microbiota in Potassium Oxonate-Induced Mice. PMID: 34572357
Characterization of a Compound Heterozygous SLC2A9 Mutation That Causes Hypouricemia. PMID: 34690083
Urate transport in health and disease. PMID: 34044255
Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway. PMID: 29393108
Gout: A Disease of Kings. PMID: 34699754
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. PMID: 27456670
Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout. PMID: 18606621
SLC2A9--a fructose transporter identified as a novel uric acid transporter. PMID: 30105595
SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney. PMID: 20110790
Genetics of gout. PMID: 35340212
No Evidence for a Causal Link between Serum Uric Acid and Nonalcoholic Fatty Liver Disease from the Dongfeng-Tongji Cohort Study. PMID: 31016517
Association between SLC2A9 Genetic Variants and Risk of Hyperuricemia in a Uygur Population. PMID: 20209635
The protein family of glucose transport facilitators: It's not only about glucose after all. PMID: 26345926
SLC2A9 and ZNF518B polymorphisms correlate with gout-related metabolic indices in Chinese Tibetan populations. PMID: 25209865
Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α. PMID: 31131560
Amplicon targeted resequencing for SLC2A9 and SLC22A12 identified novel mutations in hypouricemia subjects. PMID: 28711141
Genomic Influences on Hyperuricemia and Gout. PMID: 23349133
Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load. PMID: 34499869
Identification of two novel heterozygous SLC2A9 mutations in a Chinese woman and review of literature. PMID: 35246462
E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice. PMID: 25889045
An update on the genetic architecture of hyperuricemia and gout. PMID: 21516695
[Hereditary hypouricemia]. PMID: 22212408
Effects of SLC2A9 variants on uric acid levels in a Korean population. PMID: 36388056
Identification of prognostic miRNA-mRNA regulatory network in the progression of HCV-associated cirrhosis to hepatocellular carcinoma. PMID: 32759716
Evaluation of the Influence of Genetic Variants of SLC2A9 (GLUT9) and SLC22A12 (URAT1) on the Development of Hyperuricemia and Gout. PMID: 36518662
SLC2As as diagnostic markers and therapeutic targets in LUAD patients through bioinformatic analysis. PMID: 22132989
The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice. PMID: 21186168
Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families. PMID: 26552468
Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population. PMID: 27119840
[ROLE OF SLC2A9 AND ABCG2 GENE POLYMORPHISMS IN ORIGIN OF HYPERURICEMIA AND GOUT]. PMID: 27116386
A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia. PMID: 24858040
The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. PMID: 20613716
A 'complexity' of urate transporters. PMID: 22945592
The genetics of hyperuricaemia and gout. PMID: 37176161
Pathogenic Variants of SLC22A12 (URAT1) and SLC2A9 (GLUT9) in Spanish Patients with Renal Hypouricemia: Founder Effect of SLC2A9 Variant c.374C>T; p.(T125M). PMID: 29215084
Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout. PMID: 22000646
Urate transporters: an evolving field. PMID: 21584282
The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese. PMID: 36006548
The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease. PMID: 18327256
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. PMID: 21088231
GLUTs and mammalian sperm metabolism. PMID: 23852331
Urate transporters in the genomic era. PMID: 23583561
Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals. PMID: 21752574
[The epidemiology and genetic of gout]. PMID: 19926891
Homozygous SLC2A9 mutations cause severe renal hypouricemia. PMID: 29393102
Renal Handling of Uric Acid. PMID: 20589538
Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson's disease. PMID: 33087043
The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis. PMID: 26554771
Correlation of GLUT9 Polymorphisms With Gout Risk. PMID: 25833971
Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study. PMID: 25007794
Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations. PMID: 27225847
Additive composite ABCG2, SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk. PMID: 32806975
The haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 increases the hyperuricaemia risk and alcohol, chicken and processed meat intakes and smoking interact with its risk. PMID: 21658257
The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity. PMID: 25476142
Association of an Exon SNP of SLC2A9 Gene with Hyperuricemia Complicated with Type 2 Diabetes Mellitus in the Chinese Male Han Population. PMID: 24301058
Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. PMID: 24628802
Recurrent exercise-induced acute kidney injury by idiopathic renal hypouricemia with a novel mutation in the SLC2A9 gene and literature review. PMID: 37012869
A review on gout: Looking back and looking ahead. PMID: 25100214
Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. PMID: 24379826
Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. PMID: 20472486
The genetic basis of hyperuricaemia and gout. PMID: 21270912
Hypouricemia and tubular transport of uric acid. PMID: 32778763
Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. PMID: 22132990
Increased expression of SLC2A9 decreases urate excretion from the kidney. PMID: 23291366
Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. PMID: 18327257
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. PMID: 23627979
Uric acid metabolism in pre-hypertension and the metabolic syndrome. PMID: 20837191
Gout: epitome of painful arthritis. PMID: 31638209
Idiopathic renal hypouricemia: A case report and literature review. PMID: 19723617
Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders. PMID: 23272134
Changes in uric acid levels following bariatric surgery are not associated with SLC2A9 variants in the Swedish Obese Subjects Study. PMID: 18989453
Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. PMID: 30350810
Association of solute carrier family 2, member 9 (SLC2A9) genetic variant rs3733591 with gout in a Malay sample set. PMID: 24445479
Uricosuric drugs: the once and future therapy for hyperuricemia? PMID: 36327817
SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma. PMID: 24723238
Protein expression of urate transporters in renal tissue of patients with uric acid nephrolithiasis. PMID: 23307580
Genetics of hyperuricemia and gout: implications for the present and future. PMID: 20197412
Variation in the uric acid transporter gene (SLC2A9) and memory performance. PMID: 26098658
[Gout - from pathogenesis to treatment - progress in the XXI century]. PMID: 21810765
Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2. PMID: 20972595
Association of an intronic SNP of SLC2A9 gene with serum uric acid levels in the Chinese male Han population by high-resolution melting method. PMID: 24940677
For research use only. Not for human or drug use.
