Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study., PMID:36221101
SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma., PMID:36327817
Identification of prognostic miRNA-mRNA regulatory network in the progression of HCV-associated cirrhosis to hepatocellular carcinoma., PMID:36388056
The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics., PMID:36398357
SLC2As as diagnostic markers and therapeutic targets in LUAD patients through bioinformatic analysis., PMID:36518662
Genetic and Physiological Effects of Insulin-Like Growth Factor-1 (IGF-1) on Human Urate Homeostasis., PMID:36735516
Genetic and Epigenetic Regulation of the Innate Immune Response to Gout., PMID:36745138
Development of a novel prognostic signature derived from enhancer RNA-regulated genes in head neck squamous cell carcinoma., PMID:36786387
A review on gout: Looking back and looking ahead., PMID:37012869
Immunotherapy and Immune Infiltration in Patients with Clear Cell Renal Cell Carcinoma: A Comprehensive Analysis., PMID:37065178
Pathogenic Variants of SLC22A12 (URAT1) and SLC2A9 (GLUT9) in Spanish Patients with Renal Hypouricemia: Founder Effect of SLC2A9 Variant c.374C>T; p.(T125M)., PMID:37176161
GLUT9 as a potential drug target for chronic kidney disease: Drug target validation by a Mendelian randomization study., PMID:37308567
Pharmacogenetics of sodium-glucose co-transporter-2 inhibitors: Validation of a sex-agnostic pharmacodynamic biomarker., PMID:37608471
New SLC22A12 (URAT1) Variant Associated with Renal Hypouricemia Identified by Whole-Exome Sequencing Analysis and Bioinformatics Predictions., PMID:37761963
Genotype and Phenotype of Renal Hypouricemia: A Single-Center Study from China., PMID:37971623
Single-nucleotide polymorphisms link gout with health-related lifestyle factors in Korean cohorts., PMID:38060535
Recurrent exercise-induced acute kidney injury associated with hypouricemia: a case report and literature review., PMID:38129773
Raised CK and acute kidney injury following intense exercise in three patients with a history of exercise intolerance due to homozygous mutations in SLC2A9., PMID:38150892
Chinese Sumac (Rhus chinensis Mill.) Fruits Prevent Hyperuricemia and Uric Acid Nephropathy in Mice Fed a High-Purine Yeast Diet., PMID:38257077
Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)., PMID:38275575
Analyzing chemical composition of Sargentodoxae caulis water extract and their hypouricemia effect in hyperuricemic mice., PMID:38537887
Mechanisms of epigallocatechin gallate (EGCG) in ameliorating hyperuricemia: insights into gut microbiota and intestinal function in a mouse model., PMID:38757391
Biochemical characterization of renal hypouricemia-associated mutations in urate transporter genes using human cells., PMID:38811494
[Uric Acid Metabolism, Uric Acid Transporters and Dysuricemia]., PMID:38825475
Structural basis for urate recognition and apigenin inhibition of human GLUT9., PMID:38866775
Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells., PMID:38905201
The impact of chrysanthemi indici flos-enriched flavonoid part on the model of hyperuricemia based on inhibiting synthesis and promoting excretion of uric acid., PMID:38925319
Caffeine Inhibits Both Basal and Insulin-Activated Urate Transport., PMID:38932509
Solute Carrier Transporters in Synovial Membrane and Hoffa's Pad of Patients with Rheumatoid Arthritis., PMID:38932672
D-glucaro-1,4-lactone improves Diethylnitrosamine induced hepatocellular carcinoma in rats via the uric acid-ROS pathway., PMID:38996947
Ilex cornuta leaves extracts ameliorate hyperuricemia by modulating uric acid transporters., PMID:39069031
Unmasking the silent culprit: recurrent exercise-induced acute kidney injury in a Chinese adolescent with renal hypouricemia., PMID:39107999
Prognostic Model and Immune Response of Clear Cell Renal Cell Carcinoma Based on Co-Expression Genes Signature., PMID:39129082
Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol., PMID:39137147
Association of Functional Genetic Variations in Uric Acid Transporters with the Risk of Idiopathic Male Infertility: A Genetic Association Study and Bioinformatic Analysis., PMID:39141156
[First detection of the SLC2A9:p.C188F gene defect in a German Hunting Terrier with ammonium urate urolithiasis]., PMID:39173651
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells., PMID:39393275
Network Pharmacology Combined with Experimental Validation to Investigate the Mechanism of the Anti-Hyperuricemia Action of Portulaca oleracea Extract., PMID:39458543
The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of GLUT9/SLC2A9 isoforms in a drug discovery program., PMID:39522878
Triglyceride-glucose index and its additive interaction with ABCG2/SLC2A9 polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study., PMID:39607832
Anti-hyperuricemic effects of the seeds of Hovenia acerba in hyperuricemia mice., PMID:39643021
Mechanism of intestinal flora affecting SLC2A9 transport function to promote the formation of hyperuricemia., PMID:39698087
Red blood cell urate levels are linked to hemolysis in vitro and post-transfusion as a function of donor sex, population and genetic polymorphisms in SLC2A9 and ABCG2., PMID:39828898
A multi-ancestry genome-wide association study and evaluation of polygenic scores of LDL-C levels., PMID:39909172
Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter., PMID:39937868
Oleanolic Acid Alleviates Hyperuricemia via Gut Microbiota Control the Integrity of Gut Barrier and the Expressions of Urate Transporter in Mice., PMID:39973149
Analysis of microRNA expression in patients with uric acid calculi., PMID:40186757
Structural basis of urate transport by glucose transporter 9., PMID:40186864
Acute Kidney Injury and Chronic Kidney Disease Associated with a Genetic Defect: A Report of Two Cases., PMID:40429823
Alleviating the Effects of Electrolyzed Alkaline Water on Hyperuricemia in Mice., PMID:40431413
Association of an intronic SNP of SLC2A9 gene with serum uric acid levels in the Chinese male Han population by high-resolution melting method. PMID: 24940677
Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2. PMID: 20972595
[Gout - from pathogenesis to treatment - progress in the XXI century]. PMID: 21810765
Variation in the uric acid transporter gene (SLC2A9) and memory performance. PMID: 26098658
Genetics of hyperuricemia and gout: implications for the present and future. PMID: 20197412
Protein expression of urate transporters in renal tissue of patients with uric acid nephrolithiasis. PMID: 23307580
SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma. PMID: 24723238
Uricosuric drugs: the once and future therapy for hyperuricemia? PMID: 36327817
Association of solute carrier family 2, member 9 (SLC2A9) genetic variant rs3733591 with gout in a Malay sample set. PMID: 24445479
Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. PMID: 30350810
Changes in uric acid levels following bariatric surgery are not associated with SLC2A9 variants in the Swedish Obese Subjects Study. PMID: 18989453
Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders. PMID: 23272134
Idiopathic renal hypouricemia: A case report and literature review. PMID: 19723617
Gout: epitome of painful arthritis. PMID: 31638209
Uric acid metabolism in pre-hypertension and the metabolic syndrome. PMID: 20837191
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. PMID: 23627979
Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. PMID: 18327257
Increased expression of SLC2A9 decreases urate excretion from the kidney. PMID: 23291366
Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects. PMID: 22132990
Hypouricemia and tubular transport of uric acid. PMID: 32778763
The genetic basis of hyperuricaemia and gout. PMID: 21270912
Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. PMID: 20472486
Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. PMID: 24379826
A review on gout: Looking back and looking ahead. PMID: 25100214
Recurrent exercise-induced acute kidney injury by idiopathic renal hypouricemia with a novel mutation in the SLC2A9 gene and literature review. PMID: 37012869
Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. PMID: 24628802
Association of an Exon SNP of SLC2A9 Gene with Hyperuricemia Complicated with Type 2 Diabetes Mellitus in the Chinese Male Han Population. PMID: 24301058
The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity. PMID: 25476142
The haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 increases the hyperuricaemia risk and alcohol, chicken and processed meat intakes and smoking interact with its risk. PMID: 21658257
Additive composite ABCG2, SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk. PMID: 32806975
Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations. PMID: 27225847
Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study. PMID: 25007794
Correlation of GLUT9 Polymorphisms With Gout Risk. PMID: 25833971
The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis. PMID: 26554771
Variation in the uric acid transporter gene SLC2A9 and its association with AAO of Parkinson's disease. PMID: 33087043
Renal Handling of Uric Acid. PMID: 20589538
Homozygous SLC2A9 mutations cause severe renal hypouricemia. PMID: 29393102
[The epidemiology and genetic of gout]. PMID: 19926891
Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals. PMID: 21752574
Urate transporters in the genomic era. PMID: 23583561
GLUTs and mammalian sperm metabolism. PMID: 23852331
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. PMID: 21088231
The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease. PMID: 18327256
The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese. PMID: 36006548
Urate transporters: an evolving field. PMID: 21584282
Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout. PMID: 22000646
Pathogenic Variants of SLC22A12 (URAT1) and SLC2A9 (GLUT9) in Spanish Patients with Renal Hypouricemia: Founder Effect of SLC2A9 Variant c.374C>T; p.(T125M). PMID: 29215084
The genetics of hyperuricaemia and gout. PMID: 37176161
A 'complexity' of urate transporters. PMID: 22945592
The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. PMID: 20613716
A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia. PMID: 24858040
[ROLE OF SLC2A9 AND ABCG2 GENE POLYMORPHISMS IN ORIGIN OF HYPERURICEMIA AND GOUT]. PMID: 27116386
Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population. PMID: 27119840
Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families. PMID: 26552468
The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice. PMID: 21186168
SLC2As as diagnostic markers and therapeutic targets in LUAD patients through bioinformatic analysis. PMID: 22132989
Evaluation of the Influence of Genetic Variants of SLC2A9 (GLUT9) and SLC22A12 (URAT1) on the Development of Hyperuricemia and Gout. PMID: 36518662
Identification of prognostic miRNA-mRNA regulatory network in the progression of HCV-associated cirrhosis to hepatocellular carcinoma. PMID: 32759716
Effects of SLC2A9 variants on uric acid levels in a Korean population. PMID: 36388056
[Hereditary hypouricemia]. PMID: 22212408
An update on the genetic architecture of hyperuricemia and gout. PMID: 21516695
E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice. PMID: 25889045
Identification of two novel heterozygous SLC2A9 mutations in a Chinese woman and review of literature. PMID: 35246462
Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load. PMID: 34499869
Genomic Influences on Hyperuricemia and Gout. PMID: 23349133
Amplicon targeted resequencing for SLC2A9 and SLC22A12 identified novel mutations in hypouricemia subjects. PMID: 28711141
Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α. PMID: 31131560
SLC2A9 and ZNF518B polymorphisms correlate with gout-related metabolic indices in Chinese Tibetan populations. PMID: 25209865
The protein family of glucose transport facilitators: It's not only about glucose after all. PMID: 26345926
Association between SLC2A9 Genetic Variants and Risk of Hyperuricemia in a Uygur Population. PMID: 20209635
No Evidence for a Causal Link between Serum Uric Acid and Nonalcoholic Fatty Liver Disease from the Dongfeng-Tongji Cohort Study. PMID: 31016517
Genetics of gout. PMID: 35340212
SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney. PMID: 20110790
SLC2A9--a fructose transporter identified as a novel uric acid transporter. PMID: 30105595
Clinical significance of SLC2A9/GLUT9 rs11722228 polymorphisms in gout. PMID: 18606621
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. PMID: 27456670
Gout: A Disease of Kings. PMID: 34699754
Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway. PMID: 29393108
Urate transport in health and disease. PMID: 34044255
Characterization of a Compound Heterozygous SLC2A9 Mutation That Causes Hypouricemia. PMID: 34690083
Impact of Camellia japonica Bee Pollen Polyphenols on Hyperuricemia and Gut Microbiota in Potassium Oxonate-Induced Mice. PMID: 34572357
Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis. PMID: 34444825
SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1. PMID: 32258131
Association between SLC2A9 (GLUT9) gene polymorphisms and gout susceptibility: an updated meta-analysis. PMID: 30427222
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase. PMID: 27255295
Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells. PMID: 33075645
Associations between SLC2A9 polymorphisms and gout susceptibility : A meta-analysis. PMID: 29523220
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion. PMID: 27052299
Genetic and Epigenetic Regulation of the Innate Immune Response to Gout. PMID: 32488095
SLC2A9 is a high-capacity urate transporter in humans. PMID: 36745138
SLC2A9 Genotype Is Associated with SLC2A9 Gene Expression and Urinary Uric Acid Concentration. PMID: 18842065
Expression of SLC2A9 isoforms in the kidney and their localization in polarized epithelial cells. PMID: 26167684
Dietary Fructose Promotes Prostate Cancer Growth. PMID: 24409316
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. PMID: 33762358
Mouse models for human hyperuricaemia: a critical review. PMID: 31118497
The Role of the Intestine in the Development of Hyperuricemia. PMID: 35281005
The molecular physiology of uric acid homeostasis. PMID: 25422986
The biology of urate. PMID: 32620198
Uric acid transport and disease. PMID: 20516647
For research use only. Not for human or drug use.
