Catalog No.
YHK89201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys91-Ala207
Predicted molecular weight
16.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NPF5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1425, DMAP1, DNMAP1, DNA methyltransferase 1-associated protein 1, DNMT1-associated protein 1
CDK4/6 inhibition triggers anti-tumour immunity. PMID: 28813415
MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins. PMID: 32403252
DMAP1 is an essential regulator of ATM activity and function. PMID: 23318425
Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process. PMID: 19845771
Distinct roles of DMAP1 in mouse development. PMID: 21383065
The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes. PMID: 14734556
RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity. PMID: 31531894
Silencing of the DNA methyltransferase 1 associated protein 1 (DMAP1) gene in the invasive ladybird Harmonia axyridis implies a role of the DNA methyltransferase 1-DMAP1 complex in female fecundity. PMID: 30553276
C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer. PMID: 34834420
Comprehensive Combined Proteomics and Genomics Analysis Identifies Prognostic Related Transcription Factors in Breast Cancer and Explores the Role of DMAP1 in Breast Cancer. PMID: 20864525
DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair. PMID: 30932271
CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors. PMID: 24947515
The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response. PMID: 24559687
Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway. PMID: 10888872
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. PMID: 14978102
Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. PMID: 20920467
Corepressor MMTR/DMAP1 is an intrinsic negative regulator of CAK kinase to regulate cell cycle progression. PMID: 20387133
Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells. PMID: 31783872
Correction to: c-Src confers resistance to mitotic stress through inhibition of DMAP1/Bub3 complex formation in pancreatic cancer. PMID: 32272809
ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition. PMID: 17371848
Corepressor MMTR/DMAP1 is involved in both histone deacetylase 1- and TFIIH-mediated transcriptional repression. PMID: 17214966
Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing. PMID: 26206665
MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome. PMID: 29270191
Tissue-Specific Expression of DNA Methyltransferases Involved in Early-Life Nutritional Stress of Chicken, Gallus gallus. PMID: 21944426
Epstein-Barr virus-associated gastric carcinoma. PMID: 30396999
DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. PMID: 20107327
Uncovering a unique role for DNA methylation in hematopoietic and leukemic stem cells. PMID: 25042654
DNA methylation inhibition: a novel therapeutic strategy for heart failure. PMID: 26585710
Metabolic-epigenetic crosstalk in macrophage activation. PMID: 25838424
Endothelial epigenetics in biomechanical stress: disturbed flow-mediated epigenomic plasticity in vivo and in vitro. PMID: 30542120
Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma. PMID: 32153366
DIP2B Interacts With α-Tubulin to Regulate Axon Outgrowth. PMID: 14665632
Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. PMID: 16570848
Establishment and maintenance of DNA methylation patterns in mammals. PMID: 11389535
DNA methylation, nuclear structure, gene expression and cancer. PMID: 30397228
Epigenome-wide methylation differences in a group of lean and obese women - A HUNT Study. PMID: 31838136
NALP3 orchestrates cellular bioenergetics to facilitate non-small cell lung cancer cell growth. PMID: 16049569
Chromatin, DNA methylation and neuron gene regulation--the purpose of the package. PMID: 32686935
Transcriptional Changes in the Ovaries of Perch from Chernobyl. PMID: 17965604
On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme. PMID: 36773604
Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas. PMID: 23809695
Specific inhibition of one DNMT1-including complex influences tumor initiation and progression. PMID: 25960197
Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. PMID: 27664947
Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain. PMID: 15367675
Subcellular localization of RPB5-mediating protein and its putative functional partner. PMID: 15240889
Cre-lox-regulated conditional RNA interference from transgenes. PMID: 25197808
HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency. PMID: 24937014
Selective role for DNMT3a in learning and memory. PMID: 30305430
IDH1 mutation promotes lung cancer cell proliferation through methylation of Fibulin-5. PMID: 20499676
[Mechanism of DNA methylation and demethylation--its role in control of genes expression]. PMID: 26095369
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. PMID: 26975253
Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome. PMID: 23241950
Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice. PMID: 35345359
Differential Expression of Zinc-Dependent HDAC Subtypes and their Involvement in Unique Pathways Associated with Carcinogenesis. PMID: 21619587
PKC isoforms interact with and phosphorylate DNMT1. PMID: 33387775
The anti-lipidemic drug simvastatin modifies epigenetic biomarkers in the amphipod Gammarus locusta. PMID: 29466247
Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1. PMID: 26721438
Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication. PMID: 27487275
DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma? PMID: 18567946
The early expressed HIV-1 genes regulate DNMT1 expression. PMID: 23145775
Reactivation of RASSF1A in breast cancer cells by curcumin. PMID: 17967891
LSH cooperates with DNA methyltransferases to repress transcription. PMID: 17931718
DNMT1 interacts with the developmental transcriptional repressor HESX1. PMID: 32861793
Silencing of miR-152 contributes to DNMT1-mediated CpG methylation of the PTEN promoter in bladder cancer. PMID: 14712760
[DNA methylation and cancer--DNA methylation as a target of cancer chemotherapy]. PMID: 31365782
MiR-424 prevents astrogliosis after cerebral ischemia/reperfusion in elderly mice by enhancing repressive H3K27me3 via NFIA/DNMT1 signaling. PMID: 15033475
Physical and functional interactions between Daxx and TSG101. PMID: 26606905
High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice. PMID: 19110320
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. PMID: 20081831
DNMT1 maintains progenitor function in self-renewing somatic tissue. PMID: 26257392
For research use only. Not for human or drug use.
