Catalog No.
YHK89101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu543-His648
Predicted molecular weight
25.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UJQ4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Sal-like protein 4, SALL4, Zinc finger protein SALL4, Zinc finger protein 797, ZNF797
SALL4-Related Disorders. PMID: 20301547
SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance. PMID: 35216168
SALL4: An Intriguing Therapeutic Target in Cancer Treatment. PMID: 36010677
SALL4 as a transcriptional and epigenetic regulator in normal and leukemic hematopoiesis. PMID: 29308206
SALL4: an emerging cancer biomarker and target. PMID: 25444934
SALL4: engine of cell stemness. PMID: 25174577
SALL4, the missing link between stem cells, development and cancer. PMID: 26892498
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. PMID: 30067223
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4. PMID: 34417458
SALL4 and microRNA: The Role of Let-7. PMID: 34573282
New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. PMID: 31446059
Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy. PMID: 35613022
Role of SALL4 in hematopoiesis. PMID: 22555391
Potential application of human SALL4 on oral squamous cell carcinoma. PMID: 36172107
Functional and clinical significance of SALL4 in breast cancer. PMID: 27444278
The teratogenic effects of thalidomide on limbs. PMID: 30335598
Oncofetal gene SALL4 and prognosis in cancer: A systematic review with meta-analysis. PMID: 28160555
Recent updates in thoracic SMARCA4-deficient undifferentiated tumor. PMID: 34147303
Sall4 Guides p53-Mediated Enhancer Interference upon DNA Damage in Mouse Embryonic Stem Cells. PMID: 35977539
Sall4 in "stemness"-driven hepatocarcinogenesis. PMID: 23758237
SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis. PMID: 32489324
Recent advances in the molecular mechanism of thalidomide teratogenicity. PMID: 32304852
Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy. PMID: 34593523
SALL4 is a useful marker for pediatric yolk sac tumors. PMID: 32222813
The role of stem cell factor SALL4 in leukemogenesis. PMID: 22150312
Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex. PMID: 32251415
SALL4 promotes tumor progression in breast cancer by targeting EMT. PMID: 32835442
SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature. PMID: 33367658
Serum SALL4 as a predictive biomarker for the prognosis of patients with hepatocellular carcinoma who underwent nonsurgical treatment. PMID: 36316931
SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells. PMID: 36575044
Role of SALL4 in HER2+ Breast Cancer Progression: Regulating PI3K/AKT Pathway. PMID: 36362083
SALL4 controls cell fate in response to DNA base composition. PMID: 33406384
Dedifferentiation and the role of sall4 in reprogramming and patterning during amphibian limb regeneration. PMID: 21305648
SALL4 Gene Expression in Acute Myeloid Leukemia. PMID: 31653163
Duane Syndrome. PMID: 20301369
Oncofetal SALL4-Driven Tumorigenesis Is Highly Dependent on Oxidative Phosphorylation, Revealing Therapeutic Opportunities. PMID: 31606470
SALL4 promotes osteoblast differentiation by deactivating NOTCH2 signaling. PMID: 29241074
Targeting SALL4 by entinostat in lung cancer. PMID: 27705911
SALL4 Expression in Epithelial Gastric Cancer: Epigenetic or Epiphenomenon? PMID: 36877335
SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway. PMID: 30907073
Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos. PMID: 31235634
SALL4 promotes gastric cancer progression through activating CD44 expression. PMID: 27819668
Up-Regulation of SALL4 Is Associated With Survival and Progression via Putative WNT Pathway in Gastric Cancer. PMID: 33644042
SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis. PMID: 30349378
SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate. PMID: 30190590
Effect of SALL4 on the Proliferation, Invasion and Apoptosis of Breast Cancer Cells. PMID: 33308020
SALL4 is a marker of the embryonal subtype of hepatoblastoma. PMID: 23822878
Regulatory effect of MiR103 on proliferation, EMT and invasion of oral squamous carcinoma cell through SALL4. PMID: 33577002
Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression. PMID: 33406418
SOX2/SALL4 stemness axis modulates Notch signaling genes to maintain self-renewal capacity of esophageal squamous cell carcinoma. PMID: 33098486
CK19-positive Hepatocellular Carcinoma is a Characteristic Subtype. PMID: 32742454
Maternal Sall4 Is Indispensable for Epigenetic Maturation of Mouse Oocytes. PMID: 28031467
SALL4 correlates with proliferation, metastasis, and poor prognosis in prostate cancer by affecting MAPK pathway. PMID: 37119046
SALL4 is a new target in endometrial cancer. PMID: 24336327
SALL4 promotes glycolysis and chromatin remodeling via modulating HP1α-Glut1 pathway. PMID: 28759035
SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma. PMID: 26317546
SALL4 oncogene is an immunogenic antigen presented in various HLA-DR contexts. PMID: 29632725
Knockdown of SALL4 inhibits the proliferation, migration, and invasion of human lung cancer cells in vivo and in vitro. PMID: 33490190
Expression and clinical value of SALL4 in renal cell carcinomas. PMID: 32468053
The Invasion and Metastasis of Colon Adenocarcinoma (COAD) Induced by SALL4. PMID: 35692499
The NuRD complex cooperates with SALL4 to orchestrate reprogramming. PMID: 37208322
SALL4-related gene signature defines a specific stromal subset of pancreatic ductal adenocarcinoma with poor prognostic features. PMID: 36587397
Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury. PMID: 33718351
SALL4 promotes the tumorigenicity of cervical cancer cells through activation of the Wnt/β-catenin pathway via CTNNB1. PMID: 31336010
Role of SALL4 and Nodal in the prognosis and tamoxifen resistance of estrogen receptor-positive breast cancer. PMID: 34476264
Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner. PMID: 25246269
Transcriptome analysis reveals SALL4 as a prognostic key gene in gastric adenocarcinoma. PMID: 35284980
Normal embryonic development and neonatal digit regeneration in mice overexpressing a stem cell factor, Sall4. PMID: 35482646
Identification of SALL4 Expressing Islet-1+ Cardiovascular Progenitor Cell Clones. PMID: 36675298
Spalt-Like Protein 4 (SALL4) Promotes Angiogenesis by Activating Vascular Endothelial Growth Factor A (VEGFA) Signaling. PMID: 32116289
Study on the mechanism of SALL4 down-regulation in promoting the invasion and migration of oral squamous cell carcinoma and influencing the survival and prognosis of patients. PMID: 35965794
The Study of SALL4 Gene and BMI-1 Gene Expression in Acute Myeloid Leukemia Patients. PMID: 31552409
Retraction notice to MicroRNA-98 Plays a Suppressive Role in Non-Small Cell Lung Cancer Through Inhibition of SALL4 Protein Expression [Oncology Research 25(6) (2017) 975-988]. PMID: 34503608
SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway. PMID: 28887597
SALL4, a novel marker for human gastric carcinogenesis and metastasis. PMID: 24276240
SALL4 as a new biomarker for early colorectal cancers. PMID: 25156818
For research use only. Not for human or drug use.
