Catalog No.
YHK89001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr55-Asn100
Predicted molecular weight
17.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96KJ9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
COX IV-2, Cytochrome c oxidase subunit 4 isoform 2, mitochondrial, COX4I2, Cytochrome c oxidase subunit IV isoform 2, COX4L2
COX4I2 is a novel biomarker of blood supply in adrenal tumors. PMID: 34430392
Fibroblasts mediate the angiogenesis of pheochromocytoma by increasing COX4I2 expression. PMID: 36172142
Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC. PMID: 36064310
Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells. PMID: 34026834
Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3-COX4I2 Axis Attenuates Osteoarthritis Progression. PMID: 36683245
A SNP of the COX4I2 gene associated with environmental adaptation in Chinese cattle. PMID: 36379384
Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity. PMID: 32075102
Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines. PMID: 26263558
Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. PMID: 28620066
Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. PMID: 19268275
Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. PMID: 22730437
Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses. PMID: 21059062
Moderate and high intensity sprint exercise induce differential responses in COX4I2 and PDK4 gene expression in Thoroughbred horse skeletal muscle. PMID: 21059063
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. PMID: 23303788
MNRR1, a Biorganellar Regulator of Mitochondria. PMID: 28685009
Mitochondrial CHCHD2: Disease-Associated Mutations, Physiological Functions, and Current Animal Models. PMID: 33967741
The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice. PMID: 24763053
Mitochondrial oxygen sensing of acute hypoxia in specialized cells - Is there a unifying mechanism? PMID: 35988811
Decreased mixed lineage leukemia 1 is involved in endometriosis-related infertility. PMID: 33151904
From clinic to mechanism: Proteomics-based assessment of angiogenesis in adrenal pheochromocytoma. PMID: 31106414
Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4. PMID: 31964803
Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency. PMID: 33672589
ACE inhibition modifies exercise-induced pro-angiogenic and mitochondrial gene transcript expression. PMID: 26407530
Alterations in oxidative gene expression in equine skeletal muscle following exercise and training. PMID: 19861432
Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia. PMID: 35929074
Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. PMID: 34558219
Flaxseed Polysaccharide Alters Colonic Gene Expression of Lipid Metabolism and Energy Metabolism in Obese Rats. PMID: 35804806
Skeletal Muscle Signaling Following Whole-Body and Localized Heat Exposure in Humans. PMID: 32765299
Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression. PMID: 20602186
Single cell transcriptome analysis of mouse carotid body glomus cells. PMID: 26940531
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism. PMID: 25315652
Astaxanthin Carotenoid Modulates Oxidative Stress in Adipose-Derived Stromal Cells Isolated from Equine Metabolic Syndrome Affected Horses by Targeting Mitochondrial Biogenesis. PMID: 36008933
Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration. PMID: 27913209
Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors. PMID: 31848220
Differential HIF2α Protein Expression in Human Carotid Body and Adrenal Medulla under Physiologic and Tumorigenic Conditions. PMID: 35740651
DNA methylation study of Huntington's disease and motor progression in patients and in animal models. PMID: 32913184
Activation of TNFR1 and TLR4 following oxygen glucose deprivation promotes mitochondrial fission in C6 astroglial cells. PMID: 32693013
An interstitial 20q11.21 microdeletion causing mild intellectual disability and facial dysmorphisms. PMID: 23476833
Increased incidence of intermittent hypoxemia in the Ts65Dn mouse model of Down syndrome. PMID: 26240993
MicroRNAs Regulate Cellular ATP Levels by Targeting Mitochondrial Energy Metabolism Genes during C2C12 Myoblast Differentiation. PMID: 26010876
High-resolution melting analysis of 15 genes in 60 patients with cytochrome-c oxidase deficiency. PMID: 22592081
Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus. PMID: 25107643
Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. PMID: 30922174
Introducing a panel for early detection of lung adenocarcinoma by using data integration of genomics, epigenomics, transcriptomics and proteomics. PMID: 31843580
Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes. PMID: 26030260
Polybrominated diphenyl ethers and arylhydrocarbon receptor agonists: Different toxicity and target gene expression. PMID: 20566336
Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. PMID: 24159189
Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial. PMID: 24492839
Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid/carbohydrate metabolism. PMID: 29993148
Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses. PMID: 26991374
Comparative analysis of the hepatopancreas transcriptome of grass carp (Ctenopharyngodon idellus) fed with lard oil and fish oil diets. PMID: 25865300
Inducers of chemical hypoxia act in a gender- and brain region-specific manner on primary astrocyte viability and cytochrome C oxidase. PMID: 20734249
Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells. PMID: 22320183
For research use only. Not for human or drug use.
