Catalog No.
YHK88701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser2-Arg65
Predicted molecular weight
19.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96SN7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ORAI2, C7orf19, Protein orai-2, CAP-binding protein complex-interacting protein 2, CBCIP2, Transmembrane protein 142B, TMEM142B
ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly. PMID: 33310726
Orai2 deficiency attenutates experimental colitis by facilitating the colonization of Akkermansia muciniphila. PMID: 36070824
Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α-stimulated astrocytes. PMID: 35506586
Orai1- and Orai2-, but not Orai3-mediated ICRAC is regulated by intracellular pH. PMID: 34877682
Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells. PMID: 35008277
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels. PMID: 32896813
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. PMID: 28294127
The neglected CRAC proteins: Orai2, Orai3, and STIM2. PMID: 23890118
ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. PMID: 32929002
ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells. PMID: 32722509
Blockade of Platelet Glycoprotein Ibα Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion. PMID: 36012752
Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels. PMID: 17463004
Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines. PMID: 25769459
Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis. PMID: 29604961
Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation. PMID: 27865925
Loss of Orai2-Mediated Capacitative Ca2+ Entry Is Neuroprotective in Acute Ischemic Stroke. PMID: 31551038
Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses. PMID: 31772693
Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension. PMID: 32166015
Leucine-rich repeat kinase 2 regulates mouse dendritic cell migration by ORAI2. PMID: 31166814
Regulation of store-operated Ca2+ entry activity by cell cycle dependent up-regulation of Orai2 in brain capillary endothelial cells. PMID: 25748572
Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. PMID: 25673771
X-Ray Causes mRNA Transcripts Change to Enhance Orai2-Mediated Ca2+ Influx in Rat Brain Microvascular Endothelial Cells. PMID: 34595206
Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells. PMID: 35126366
Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification. PMID: 37130916
Orai3: Oncochannel with therapeutic potential. PMID: 32659517
Correction: Sanchez-Collado et al. Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells. Cancers 2021, 14, 114. PMID: 36831699
Store-operated Ca(2+) entry. PMID: 22453950
Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels. PMID: 17452328
Redox modulation of STIM-ORAI signaling. PMID: 27041216
Role of Orai3 in the Pathophysiology of Cancer. PMID: 34768857
Bisbenzylisoquinoline alkaloids from Plumula Nelumbinis inhibit vascular smooth muscle cells migration and proliferation by regulating the ORAI2/Akt pathway. PMID: 37119920
Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach. PMID: 36809524
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. PMID: 16807233
Control of STIM and Orai function by post-translational modifications. PMID: 35151050
Pharmacology of store-operated calcium channels. PMID: 20729487
No social distancing between ORAI channels. PMID: 32810747
STIM and ORAI proteins in the nervous system. PMID: 26218135
The anatomy of native CRAC channel(s). PMID: 32999945
Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? PMID: 31569936
Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle. PMID: 26718630
The STIM/Orai coupling machinery. PMID: 18769136
Emerging roles of Orai3 in pathophysiology. PMID: 23695829
STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases. PMID: 35821821
Orai1 calcium channels in the vasculature. PMID: 22402985
CRAC channel regulation of innate immune cells in health and disease. PMID: 30641250
Pharmacology of Store-Operated Calcium Entry Channels. PMID: 30299647
Stim and Orai proteins in neuronal Ca(2+) signaling and excitability. PMID: 25964739
Biochemical and functional properties of the store-operated Ca2+ channels. PMID: 19049864
Physiological and pathophysiological functions of SOCE in the immune system. PMID: 22202035
CRAC channels, calcium, and cancer in light of the driver and passenger concept. PMID: 26705695
STIM/Orai signalling complexes in vascular smooth muscle. PMID: 22641780
Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology. PMID: 34360783
Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer's Disease. PMID: 34948414
Changes in expression of klotho affect physiological processes, diseases, and cancer. PMID: 29372030
ORAI-mediated calcium entry: mechanism and roles, diseases and pharmacology. PMID: 20546784
Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity. PMID: 22615435
Too much of a good thing: The case of SOCE in cellular apoptosis. PMID: 36931194
Ezh2 knockout in mesenchymal cells causes enamel hyper-mineralization. PMID: 34144503
STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis. PMID: 26017146
STIM and Orai: the long-awaited constituents of store-operated calcium entry. PMID: 19187978
New developments in the signaling mechanisms of the store-operated calcium entry pathway. PMID: 18536932
Transient receptor potential channels in human platelets: expression and functional role. PMID: 22834833
Two types of functionally distinct Ca2+ stores in hippocampal neurons. PMID: 31324793
One or Two Ca2+ Stores in the Neuronal Endoplasmic Reticulum? PMID: 31623868
Prognostic Value of MicroRNA-20b in Acute Myeloid Leukemia. PMID: 33680910
For research use only. Not for human or drug use.
