Catalog No.
YHC28701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr94-Leu543
Predicted molecular weight
53.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07947
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p61-Yes, Tyrosine-protein kinase Yes, YES1, Proto-oncogene c-Yes, YES
YES1: A Novel Therapeutic Target and Biomarker in Cancer. PMID: 35732509
YES1 Is a Druggable Oncogenic Target in SCLC. PMID: 35988891
EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis. PMID: 33941853
Peptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation. PMID: 32461121
miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy. PMID: 35012539
YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers. PMID: 31856375
YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib. PMID: 31166114
RBM15 promotes hepatocellular carcinoma progression by regulating N6-methyladenosine modification of YES1 mRNA in an IGF2BP1-dependent manner. PMID: 34707107
YES1 as a Therapeutic Target for HER2-Positive Breast Cancer after Trastuzumab and Trastuzumab-Emtansine (T-DM1) Resistance Development. PMID: 34884609
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring. PMID: 33888614
Correction to: EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis. PMID: 35046536
To Scar or Not to Scar. PMID: 34320296
Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer. PMID: 28158234
YES1 and MYC Amplifications as Synergistic Resistance Mechanisms to Different Generation ALK Tyrosine Kinase Inhibitors in Advanced NSCLC: Brief Report of Clinical and Preclinical Proofs. PMID: 35199053
Retraction. PMID: 34383338
Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer. PMID: 31970720
SRC Family Kinase Inhibition Targets YES1 and YAP1 as Primary Drivers of Lung Cancer and as Mediators of Acquired Resistance to ALK and Epidermal Growth Factor Receptor Inhibitors. PMID: 35952318
Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis. PMID: 37009887
YES1 amplification confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive cancer. PMID: 32572172
Matrine Regulates Proliferation, Apoptosis, Cell Cycle, Migration, and Invasion of Non-Small Cell Lung Cancer Cells Through the circFUT8/miR-944/YES1 Axis [Retraction]. PMID: 36545224
Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis. PMID: 31278282
YES1 activation elicited by heat stress is anti-apoptotic in mouse pachytene spermatocytes. PMID: 24132961
YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification. PMID: 31391186
Targeting VEGF-A/VEGFR2 Y949 Signaling-Mediated Vascular Permeability Alleviates Hypoxic Pulmonary Hypertension. PMID: 36384284
YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics. PMID: 29875142
Long non-coding TUG1 accelerates prostate cancer progression through regulating miR-128-3p/YES1 axis. PMID: 32016963
Identification of potent Yes1 kinase inhibitors using a library screening approach. PMID: 23787099
METTL3 promotes colorectal carcinoma progression by regulating the m6A-CRB3-Hippo axis. PMID: 35012593
Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1. PMID: 33790797
MicroRNA-133a inhibits the proliferation of non-small cell lung cancer by targeting YES1. PMID: 31807185
MiR-199a suppresses prostate cancer paclitaxel resistance by targeting YES1. PMID: 29204706
ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP. PMID: 32943576
MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells. PMID: 32462982
Circ_0057553/miR-515-5p Regulates Prostate Cancer Cell Proliferation, Apoptosis, Migration, Invasion and Aerobic Glycolysis by Targeting YES1. PMID: 33177837
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation. PMID: 33730553
Circ_0081143 Contributes to Gastric Cancer Malignant Development and Doxorubicin Resistance by Elevating the Expression of YES1 by Targeting mziR-129-2-3p. PMID: 35686503
Bioactive Phytoconstituents as Potent Inhibitors of Tyrosine-Protein Kinase Yes (YES1): Implications in Anticancer Therapeutics. PMID: 35630545
Targeting Yes1 Associated Transcriptional Regulator Inhibits Hepatocellular Carcinoma Progression and Improves Sensitivity to Sorafenib: An in vitro and in vivo Study. PMID: 33149619
Predictive Biomarkers of Response to Src Inhibitors in Lung Cancer. Getting to YES1. PMID: 31206303
The chaperone-assisted selective autophagy complex dynamics and dysfunctions. PMID: 36594740
Linkage disequilibrium and haplotype analysis of Src and Yes1 genes in thyroid cancer. PMID: 32253932
Correction: Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer. PMID: 28301577
MiR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian cancer cell lines. PMID: 25561420
Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1. PMID: 26676187
Personalized Cancer Therapy: YES1 Is the New Kid on the Block. PMID: 31772072
Matrine Regulates Proliferation, Apoptosis, Cell Cycle, Migration, and Invasion of Non-Small Cell Lung Cancer Cells Through the circFUT8/miR-944/YES1 Axis. PMID: 33907466
Role of YES1 amplification in EGFR mutation-positive non-small cell lung cancer: Primary resistance to afatinib in a patient. PMID: 32744377
Deubiquitinase ubiquitin-specific peptidase 10 maintains cysteine rich angiogenic inducer 61 expression via Yes1 associated transcriptional regulator to augment immune escape and metastasis of pancreatic adenocarcinoma. PMID: 35271750
Linc01133 contributes to gastric cancer growth by enhancing YES1-dependent YAP1 nuclear translocation via sponging miR-145-5p. PMID: 35017464
Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression. PMID: 35012996
[miR-133b inhibits myocardial ischemia-reperfusion-induced cardiomyocyte apoptosis and accumulation of reactive oxygen species in rats by targeting YES1]. PMID: 33118509
Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice. PMID: 34709991
Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells. PMID: 35435804
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. PMID: 23245941
P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases. PMID: 36799463
SIX4 promotes hepatocellular carcinoma metastasis through upregulating YAP1 and c-MET. PMID: 33046796
For research use only. Not for human or drug use.
