Catalog No.
YHK87601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly19-Thr111
Predicted molecular weight
22.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96JC9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EAF1, ELL-associated factor 1
Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/β-Catenin activity. PMID: 29910681
ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation. PMID: 32087315
Negative Feedback Loop Mechanism between EAF1/2 and DBC1 in Regulating ELL Stability and Functions. PMID: 36036574
Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis. PMID: 24445282
Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-β signaling. PMID: 28887217
Eaf1 and Eaf2 negatively regulate canonical Wnt/β-catenin signaling. PMID: 23364330
Conditional Deletion of Eaf1 Induces Murine Prostatic Intraepithelial Neoplasia in Mice. PMID: 31229879
EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein. PMID: 11418481
EAF1 regulates vegetative-phase change and flowering time in Arabidopsis. PMID: 10398702
Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis. PMID: 25841019
Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression. PMID: 19380582
ATM-mediated ELL phosphorylation enhances its self-association through increased EAF1 interaction and inhibits global transcription during genotoxic stress. PMID: 36305813
ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia. PMID: 12686606
Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. PMID: 37002435
[Effects of miR-155-3p on the degradation rate of EAF1 mRNA and malignant proliferation in HANK1 cells]. PMID: 34821091
Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants. PMID: 18212047
Negative feedback regulation of Wnt4 signaling by EAF1 and EAF2/U19. PMID: 20161747
A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans. PMID: 36066422
ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. PMID: 12446457
Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7. PMID: 28893534
Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. PMID: 29559617
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis. PMID: 34431785
The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. PMID: 11463848
Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity. PMID: 18212056
Correction to 'ATM-mediated ELL phosphorylation enhances its self-association through increased EAF1 interaction and inhibits global transcription during genotoxic stress'. PMID: 37194690
Structure of the NuA4 histone acetyltransferase complex. PMID: 36417436
Structure and flexibility of the yeast NuA4 histone acetyltransferase complex. PMID: 36263929
Allosteric transcription stimulation by RNA polymerase II super elongation complex. PMID: 34265249
The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma. PMID: 36989355
Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability. PMID: 37230009
Phenomic screen identifies a role for the yeast lysine acetyltransferase NuA4 in the control of Bcy1 subcellular localization, glycogen biosynthesis, and mitochondrial morphology. PMID: 33253187
Faster skin wound healing predicts survival after myocardial infarction. PMID: 35089808
Identification of Candidate Genes for Pigmentation in Camels Using Genotyping-by-Sequencing. PMID: 35565522
Sequence, structural and functional conservation among the human and fission yeast ELL and EAF transcription elongation factors. PMID: 34807377
Understanding obesity and program participation in the context of poverty and food insecurity. PMID: 12840164
NuA4 Lysine Acetyltransferase Complex Contributes to Phospholipid Homeostasis in Saccharomyces cerevisiae. PMID: 28455416
Merge and separation of NuA4 and SWR1 complexes control cell fate plasticity in Candida albicans. PMID: 30109121
Eafs control erythroid cell fate by regulating c-myb expression through Wnt signaling. PMID: 23717633
Proteomics investigation of human sera for determination of postoperative indicators of pulmonary cystic echinococcosis. PMID: 36631795
EAF2 regulates DNA repair through Ku70/Ku80 in the prostate. PMID: 27721405
FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity. PMID: 17395368
Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics. PMID: 36217332
Disruption in phosphate transport affects membrane lipid and lipid droplet homeostasis in Saccharomyces cerevisiae. PMID: 32462239
MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. PMID: 25575120
CD71(high) population represents primitive erythroblasts derived from mouse embryonic stem cells. PMID: 25485690
Structure function characterization of the ELL Associated Factor (EAF) from Schizosaccharomyces pombe. PMID: 29032152
Development and Validation of a Novel Diagnostic Model for Childhood Autism Spectrum Disorder Based on Ferroptosis-Related Genes. PMID: 35633787
AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. PMID: 25849764
Schizosaccharomyces pombe Pol II transcription elongation factor ELL functions as part of a rudimentary super elongation complex. PMID: 30102332
Machine Learning Identifies Six Genetic Variants and Alterations in the Heart Atrial Appendage as Key Contributors to PD Risk Predictivity. PMID: 35047012
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. PMID: 16114057
For research use only. Not for human or drug use.
