Catalog No.
YHK87501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp606-Leu903
Predicted molecular weight
35.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92667
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRKA1, S-AKAP84, AKAP149, AKAP 149, Protein kinase A-anchoring protein 1, D-AKAP-1, Dual specificity A-kinase-anchoring protein 1, AKAP1, Spermatid A-kinase anchor protein 84, A-kinase anchor protein 149 kDa, A-kinase anchor protein 1, mitochondrial
Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis. PMID: 32072193
AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease. PMID: 35844803
AKAP1 Deficiency Attenuates Diet-Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes. PMID: 33747723
A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases. PMID: 31783032
Mitochondrial Protein Akap1 Deletion Exacerbates Endoplasmic Reticulum Stress in Mice Exposed to Hyperoxia. PMID: 35370705
Akap1 Regulates Vascular Function and Endothelial Cells Behavior. PMID: 29335250
AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes. PMID: 32108342
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. PMID: 30093535
miR-199b-5p-AKAP1-DRP1 Pathway Plays a Key Role in ox-LDL-induced Mitochondrial Fission and Endothelial Apoptosis. PMID: 35331106
Mitochondrial AKAP1 supports mTOR pathway and tumor growth. PMID: 28569781
Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. PMID: 32312949
Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice. PMID: 29388469
1-Nitropyrene disrupts testosterone biogenesis via AKAP1 degradation promoted mitochondrial fission in mouse Leydig cell. PMID: 35613681
AKAP1 Regulates Mitochondrial Dynamics during the Fatty-Acid-Promoted Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes as Indicated by Proteomics Sequencing. PMID: 37175819
Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure. PMID: 29892230
Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis. PMID: 27136357
Hypoxia-induced circular RNA hsa_circ_0008450 accelerates hepatocellular cancer progression via the miR-431/AKAP1 axis. PMID: 33193848
PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics. PMID: 22049414
Correction: Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis. PMID: 27384315
A-kinase anchor protein 1 (AKAP1) regulates cAMP-dependent protein kinase (PKA) localization and is involved in meiotic maturation of porcine oocytes. PMID: 23426434
A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease. PMID: 31991888
Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. PMID: 29092894
Higher expression of A-kinase anchoring-protein 1 predicts poor prognosis in human hepatocellular carcinoma. PMID: 29928393
Epigenetic silencing of microRNA-199a-5p promotes the proliferation of non-small cell lung cancer cells by increasing AKAP1 expression. PMID: 33868472
Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. PMID: 32855239
Mitochondria-associated endoplasmic reticulum membranes promote mitochondrial fission through AKAP1-Drp1 pathway in podocytes under high glucose conditions. PMID: 36775185
NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. PMID: 10352013
Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. PMID: 21526220
Characterization of RII(beta) and D-AKAP1 in differentiated adipocytes. PMID: 11742813
Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function. PMID: 24412345
Short RNA molecules with high binding affinity to the KH motif of A-kinase anchoring protein 1 (AKAP1): implications for the regulation of steroidogenesis. PMID: 23077346
Mitochondrial PKA Is Neuroprotective in a Cell Culture Model of Alzheimer's Disease. PMID: 33624140
A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury. PMID: 36263130
Serum level of A-kinase anchoring protein 1, negatively correlated with insulin resistance and body mass index, decreases slightly in patients with newly diagnosed T2DM. PMID: 32797476
Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein. PMID: 16756943
The function and mechanism of microRNA-92a-3p in lipopolysaccharide-induced acute lung injury. PMID: 34783628
Pivotal role of AKAP121 in mitochondrial physiology. PMID: 26825124
PINK1 regulates mitochondrial trafficking in dendrites of cortical neurons through mitochondrial PKA. PMID: 28556983
A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. PMID: 11994283
The BBSome regulates mitochondria dynamics and function. PMID: 36513220
Mitochondrial A-kinase anchoring proteins in cardiac ventricular myocytes. PMID: 34514737
The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. PMID: 19570980
Mitochondrial a Kinase Anchor Proteins in Cardiovascular Health and Disease: A Review Article on Behalf of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology. PMID: 35887048
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. PMID: 9065479
The nuclear envelope, lamins and nuclear assembly. PMID: 12067659
How AMPK and PKA Interplay to Regulate Mitochondrial Function and Survival in Models of Ischemia and Diabetes. PMID: 29391924
D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane. PMID: 26950402
PKA, PKC, and AKAP localization in and around the neuromuscular junction. PMID: 11716788
Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. PMID: 26437602
Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy. PMID: 31349216
Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification. PMID: 33412331
PINK1 Inhibits Local Protein Synthesis to Limit Transmission of Deleterious Mitochondrial DNA Mutations. PMID: 30772175
Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study. PMID: 36274151
The effect of SiNPs on DNA methylation of genome in mouse spermatocytes. PMID: 33840017
PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy. PMID: 27091447
Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα. PMID: 31674811
DNA Methylation and Asthma Acquisition during Adolescence and Post-Adolescence, an Epigenome-Wide Longitudinal Study. PMID: 35207690
PKA-type I selective constrained peptide disruptors of AKAP complexes. PMID: 25765284
Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. PMID: 32144179
Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations. PMID: 29895819
A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface. PMID: 32482893
Dimerization/docking domain of the type Ialpha regulatory subunit of cAMP-dependent protein kinase. Requirements for dimerization and docking are distinct but overlapping. PMID: 9857038
[Progress in researches on A-kinase anchor proteins in sperm]. PMID: 15497715
Probing of protein localization and shuttling in mitochondrial microcompartments by FLIM with sub-diffraction resolution. PMID: 27016377
Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress. PMID: 30652267
Characterization of A-kinase-anchoring disruptors using a solution-based assay. PMID: 16948636
Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89. PMID: 21689781
AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription. PMID: 18786546
Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility. PMID: 30598507
Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation. PMID: 19667072
Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. PMID: 19074462
MicroRNA-148a-3p enhances cisplatin cytotoxicity in gastric cancer through mitochondrial fission induction and cyto-protective autophagy suppression. PMID: 28965855
Label-free quantitative proteomic analysis of benzo(a)pyrene-transformed 16HBE cells serum-free culture supernatant and xenografted nude mice sera. PMID: 26748308
Multi-stage screening cell-free seminal mRNAs to diagnose completion of meiosis and predict testicular sperm retrieval in men with non-obstructive azoospermia. PMID: 35266640
The A-kinase anchor protein AKAP121 is a negative regulator of cardiomyocyte hypertrophy. PMID: 19358331
Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism. PMID: 16251349
Developmentally acquired PKA localisation in mouse oocytes and embryos. PMID: 18367160
Dynamic anchoring of PKA is essential during oocyte maturation. PMID: 16461287
Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia. PMID: 18323779
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. PMID: 22099302
Peroxisome proliferator-activated receptor γ-dependent regulation of lipolytic nodes and metabolic flexibility. PMID: 22310664
AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress. PMID: 20511238
PKA-dependent binding of mRNA to the mitochondrial AKAP121 protein. PMID: 12654270
For research use only. Not for human or drug use.
