Catalog No.
EHJ27902
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Asp30-Leu243
Predicted molecular weight
26.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TD46
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, CD200R1, CD200R, CRTR2, MOX2R, OX2R, UNQ2522/PRO6015
CD200R1-CD200 checkpoint inhibits phagocytosis differently from SIRPα-CD47 to suppress tumor growth., PMID:40461553
Profiling 92 circulating neurobiological proteins identifies novel candidate biomarkers of long-term cognitive outcome after ischemic stroke., PMID:40316737
Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study., PMID:40312358
[The role of microglia activated by the deletion of immune checkpoint receptor CD200R1 gene in a mouse model of Parkinson's disease]., PMID:40065611
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088
Effects of Oral Administration of the Probiotic Lactobacillus rhamnosus GG on the Proteomic Profiles of Cerebrospinal Fluid and Immunoregulatory Signaling in the Hippocampus of Adult Male Rats., PMID:40031897
Potential drug targets for asthma identified through mendelian randomization analysis., PMID:39806440
First-in-Human Study of 23ME-00610, an Antagonistic Antibody for Genetically Validated CD200R1 Immune Checkpoint, in Participants with Advanced Solid Malignancies., PMID:39651931
CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody., PMID:39402718
Microglial priming by IFN-γ involves STAT1-mediated activation of the NLRP3 inflammasome., PMID:39392762
Deep Immune and RNA Profiling Revealed Distinct Circulating CD163+ Monocytes in Diabetes-Related Complications., PMID:39337580
The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease., PMID:39294682
Endothelial Cell-Derived Soluble CD200 Determines the Ability of Immune Cells to Cross the Blood-Brain Barrier., PMID:39273210
Knockdown of type 2 orexin receptor in adult mouse testis potentiates testosterone production and germ cell proliferation., PMID:38866320
CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway., PMID:38692160
Selective Orexin 2 Receptor Blockade Alleviates Cognitive Impairments and the Pathological Progression of Alzheimer's Disease in 3xTg-AD Mice., PMID:38682858
CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis., PMID:38396288
Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in human NSCLC., PMID:38354085
Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats., PMID:38237226
Different Transcriptome Features of Peripheral Blood Mononuclear Cells in Non-Emphysematous Chronic Obstructive Pulmonary Disease., PMID:38203236
PPAR-γ promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia., PMID:37971567
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice., PMID:37902837
Ferroptosis-related lncRNAs guiding osteosarcoma prognosis and immune microenvironment., PMID:37858131
Different mechanisms of CD200-CD200R induce diverse outcomes in cancer treatment., PMID:37734537
CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation., PMID:37391731
Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis., PMID:37291088
23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function., PMID:37288324
Single-cell RNA sequencing identifies a population of human liver-type ILC1s., PMID:36640314
CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation., PMID:36623588
The Presence of Psoriasis, Metabolic Syndrome and Their Combination Increases the Serum Levels of CRP and CD5L but Not sCD200R1 and sTLR2 in Participants., PMID:36556186
Phenotyping of M1 and M2a Macrophages and Differential Expression of ACE-2 on Monocytes by Flow Cytometry: Impact of Cell Culture Conditions and Sample Processing., PMID:36513932
Circulating CD200 is increased in the secretory phase of women with endometriosis as is endometrial mRNA, and endometrial stromal cell CD200R1 is increased in spite of reduced mRNA., PMID:36379046
Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer., PMID:36352147
Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4+ T Cells., PMID:36100367
Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker Discovery., PMID:36012423
Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients., PMID:35994639
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy., PMID:35867683
Reduced cutaneous CD200:CD200R1 signaling in psoriasis enhances neutrophil recruitment to skin., PMID:35759230
Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity., PMID:35743294
CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury., PMID:35681481
Pan-cancer analysis identifies CD300 molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia., PMID:35642341
Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice., PMID:35502705
Synthesis and characterization of a new Positron emission tomography probe for orexin 2 receptors neuroimaging., PMID:35397430
Can CD200R1 Agonists Slow the Progression of Osteoarthritis Secondary to Injury?, PMID:35359946
The Role of CD200-CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation., PMID:35326506
Altered expression of the immunoregulatory ligand-receptor pair CD200-CD200R1 in the brain of Parkinson's disease patients., PMID:35296683
CD200R family receptors are expressed on porcine monocytes and modulate the production of IL-8 and TNF-α triggered by TLR4 or TLR7 in these cells., PMID:35231818
MicroRNA-129-5p-regulated microglial expression of the surface receptor CD200R1 controls neuroinflammation., PMID:34952004
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties., PMID:34915155
Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets., PMID:34804946
For research use only. Not for human or drug use.
