Catalog No.
EHD06702
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Thr332
Predicted molecular weight
39.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P14778
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, 3.2.2.6, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, CD121a, Interleukin-1 receptor type 1, membrane form, mIL-1R1, mIL-1RI, Interleukin-1 receptor type 1, soluble form, sIL-1R1, sIL-1RI, IL1R1, IL1R, IL1RA, IL1RT1
The relationship between ghrelin, epilepsy-related inflammatory biomarkers (IL-1β, IL-1R1, HMGB1), and drug-resistant epilepsy in children., PMID:40185046
Exploring the effect of hsa-miR-19b-3p on IL-1R1 expression and serum levels in alopecia areata., PMID:39825934
Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment., PMID:39728924
Association of dietary manganese intake and the IL1R1 rs3917225 polymorphism with thyroid cancer risk: a prospective cohort study in Korea., PMID:39534923
Small molecule inhibitors of IL-1R1/IL-1β interaction identified via transfer machine learning QSAR modelling., PMID:39515709
Hub metastatic gene signature and risk score of breast cancer patients with small tumor sizes using WGCNA., PMID:39190284
Identification and Analysis of Immune Microenvironment-Related Genes for Keloid Risk Prediction and Their Effects on Keloid Proliferation and Migration., PMID:38085498
A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression., PMID:37733448
ANGPTL3 negatively regulates IL-1β-induced NF-κB activation by inhibiting the IL1R1-associated signaling complex assembly., PMID:37634084
The expression profiling and clinical significance of a chronic pain-related gene IL1R1., PMID:37571886
IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer., PMID:37460545
The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders., PMID:35163653
IL1R1 gene variants associate with disease susceptibility to IgG4-related periaortitis/periarteritis in IgG4-related disease., PMID:35143941
Expression of obesity- and type-2 diabetes-associated genes in omental adipose tissue of individuals with obesity., PMID:34995730
Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia., PMID:34923425
Molecular mechanisms in IL-1β-mediated decorin production by decidual cells., PMID:34915564
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage., PMID:34894725
The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with sudden sensorineural hearing loss in a Taiwanese population: a case control study., PMID:34865658
IL-1R1 rs6755229 polymorphism is related to death in patients undergoing major surgery who develop septic shock: a retrospective study., PMID:34647846
Potential Biomarkers in Atrial Fibrillation: Insight Into Their Clinical Significance., PMID:34173807
Association between the IL-1A, IL-1B and IL-1R polymorphisms and lymphoma., PMID:34159887
Immune-related genes LAMA2 and IL1R1 correlate with tumor sites and predict poor survival in pancreatic adenocarcinoma., PMID:34156282
Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis., PMID:33452871
Germline variants in exonic regions have limited impact on immune checkpoint blockade clinical outcomes in advanced melanoma., PMID:33449414
Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts., PMID:33436947
The novel glycyrrhetinic acid-tetramethylpyrazine conjugate TOGA induces anti-hepatocarcinogenesis by inhibiting the effects of tumor-associated macrophages on tumor cells., PMID:33031908
Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation., PMID:32841604
SUMOylation involves in β-arrestin-2-dependent metabolic regulation in breast cancer cell., PMID:32819604
The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)., PMID:32778144
The effect of IL-1R1 and IL-1RN polymorphisms on osteoporosis predisposition in a Chinese Han population., PMID:32739831
Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression., PMID:32706757
Impact of IL1R1 polymorphisms on the risk of head and neck cancer in Chinese Han population., PMID:32628975
Tumor-associated macrophage-derived inflammatory cytokine enhances malignant potential of malignant pleural mesothelioma., PMID:32530527
The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study., PMID:32252823
Macrophages reduce the sensitivity of osteosarcoma to neoadjuvant chemotherapy drugs by secreting Interleukin-1 beta., PMID:32220541
Survival genes expression analysis following ionizing radiation to LiCl treated KG1a cells., PMID:31985347
CircRNA104250 and lncRNAuc001.dgp.1 promote the PM2.5-induced inflammatory response by co-targeting miR-3607-5p in BEAS-2B cells., PMID:31864925
miR-636: A Newly-Identified Actor for the Regulation of Pulmonary Inflammation in Cystic Fibrosis., PMID:31803183
Methylation of Specific CpG Sites in IL-1β and IL1R1 Genes is Affected by Hyperglycaemia in Type 2 Diabetic Patients., PMID:31476928
Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc Degeneration., PMID:31140325
IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population., PMID:31104063
Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1β and TNF-α., PMID:31093512
Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population., PMID:31021479
IL-1β Inflammatory Cytokine-Induced TP63 Isoform ∆NP63α Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells., PMID:30641908
Impact of IL1R1 and IL1R2 gene polymorphisms on risk of osteonecrosis of the femoral head from a case-control study., PMID:30623603
High Expression of IL-1RI and EP₂ Receptors in the IL-1β/COX-2 Pathway, and a New Alternative to Non-Steroidal Drugs-Osthole in Inhibition COX-2., PMID:30620999
Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis., PMID:30597276
Interleukin-1 Receptor-Like 1 (IL1R1) Levels Are Not Increased in Healthy Centenarians., PMID:30302743
IL1R1 and IL1R2 polymorphisms were associated with tuberculosis risk: A pilot study., PMID:30256493
The IL-1/IL-1R axis induces greater fibroblast-derived chemokine release in human papillomavirus-negative compared to positive oropharyngeal cancer., PMID:30191960
For research use only. Not for human or drug use.
