Catalog No.
VHJ51101
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
RSPO3, hPWTSR, hRspo3, PWTSR, R-spondin-3, Thrombospondin type-1 domain-containing protein 2, Protein with TSP type-1 repeat, Roof plate-specific spondin-3, THSD2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9BXY4
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0181
Coactivation of Tie2 and Wnt signaling using an antibody-R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia., PMID:39607038
RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis., PMID:39245068
R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling., PMID:37406727
R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer., PMID:36106661
Not All Wnt Activation Is Equal: Ligand-Dependent versus Ligand-Independent Wnt Activation in Colorectal Cancer., PMID:33202731
Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia., PMID:32559496
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling., PMID:32432544
Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs., PMID:32160239
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis., PMID:31348891
Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)., PMID:29048660
Molecular genetics and targeted therapy of WNT-related human diseases (Review)., PMID:28731148
Preclinical development of a humanized neutralizing antibody targeting HGF., PMID:28336956
RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes., PMID:26735887
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function., PMID:26700806
For research use only. Not for human or drug use.
