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InVivoMAb Anti-HCMV/HHV5 gH/UL75 Antibody (Iv0180)

Catalog #:   VVV05101 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1, kappa
Applications: ELISA, Neutralization
Accession: P12824
Overview

Catalog No.

VVV05101

Species reactivity

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Envelope glycoprotein H, gH, gH, UL75

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P12824

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0180

Data Image
References

Characterization of human cytomegalovirus infection dynamics in human microglia., PMID:40299764

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies., PMID:40202318

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies., PMID:39829861

Human cytomegalovirus: pathogenesis, prevention, and treatment., PMID:39585514

A noncanonical glycoprotein H complex enhances cytomegalovirus entry., PMID:39416215

The Autonomous Fusion Activity of Human Cytomegalovirus Glycoprotein B Is Regulated by Its Carboxy-Terminal Domain., PMID:39339958

A broadly neutralizing human monoclonal antibody generated from transgenic mice immunized with HCMV particles limits virus infection and proliferation., PMID:38832789

Relationship of human cytomegalovirus-infected endothelial cells and circulating leukocytes in the pathogenesis of disseminated human cytomegalovirus infection: A narrative review., PMID:38282408

Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer., PMID:37967532

EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells., PMID:37146061

Fibroblast, Epithelial and Endothelial Cell-Derived Human Cytomegalovirus Strains Display Distinct Neutralizing Antibody Responses and Varying Levels of gH/gL Complexes., PMID:36901847

Human immunoglobulins are transported to HCMV viral envelope by viral Fc gamma receptors-dependent and independent mechanisms., PMID:36726564

Neutralization Epitopes in Trimer and Pentamer Complexes Recognized by Potent Cytomegalovirus-Neutralizing Human Monoclonal Antibodies., PMID:36342276

An Attenuated Strain of Human Cytomegalovirus for the Establishment of a Subviral Particle Vaccine., PMID:36016214

Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein., PMID:36000848

Human cytomegalovirus (HCMV) long-term shedding and HCMV-specific immune response in pregnant women with primary HCMV infection., PMID:35960328

Neutralizing Antibodies to Human Cytomegalovirus Recombinant Proteins Reduce Infection in an Ex Vivo Model of Developing Human Placentas., PMID:35891239

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH., PMID:35468974

Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors., PMID:35452493

Horizontal Transmission of Cytomegalovirus in a Rhesus Model Despite High-Level, Vaccine-Elicited Neutralizing Antibody and T-Cell Responses., PMID:35413121

Structural basis for HCMV Pentamer receptor recognition and antibody neutralization., PMID:35275719

Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies., PMID:35275718

Neutralizing Antibodies Limit Cell-Associated Spread of Human Cytomegalovirus in Epithelial Cells and Fibroblasts., PMID:35215877

Characterization of M116.1p, a Murine Cytomegalovirus Protein Required for Efficient Infection of Mononuclear Phagocytes., PMID:34705561

Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha., PMID:34700375

Characterization of gH/gL/pUL128-131 pentameric complex, gH/gL/gO trimeric complex, gB and gM/gN glycoproteins in a human cytomegalovirus using automated capillary western blots., PMID:34229890

A Novel Strain-Specific Neutralizing Epitope on Glycoprotein H of Human Cytomegalovirus., PMID:34160252

Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131., PMID:34132577

Detection of Genotype-Specific Antibody Responses to Glycoproteins B and H in Primary and Non-Primary Human Cytomegalovirus Infections by Peptide-Based ELISA., PMID:33802390

A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs., PMID:33729125

Antibody-Independent Quantification of Cytomegalovirus Virion Protein Incorporation Using HiBiT., PMID:33555589

Potent Bispecific Neutralizing Antibody Targeting Glycoprotein B and the gH/gL/pUL128/130/131 Complex of Human Cytomegalovirus., PMID:33361306

Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes., PMID:32746933

Cell Fusion Induced by a Fusion-Active Form of Human Cytomegalovirus Glycoprotein B (gB) Is Inhibited by Antibodies Directed at Antigenic Domain 5 in the Ectodomain of gB., PMID:32641474

Immunization with Human Cytomegalovirus Core Fusion Machinery and Accessory Envelope Proteins Elicit Strong Synergistic Neutralizing Activities., PMID:32294946

Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells., PMID:32068527

Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation., PMID:32015031

Polymorphisms in Human Cytomegalovirus Glycoprotein O (gO) Exert Epistatic Influences on Cell-Free and Cell-to-Cell Spread and Antibody Neutralization on gH Epitopes., PMID:31996433

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas., PMID:31569508

Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model., PMID:31484753

Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity., PMID:31261659

Dense Bodies of a gH/gL/UL128/UL130/UL131 Pentamer-Repaired Towne Strain of Human Cytomegalovirus Induce an Enhanced Neutralizing Antibody Response., PMID:31189713

HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission., PMID:30733288

Pathogen at the Gates: Human Cytomegalovirus Entry and Cell Tropism., PMID:30544948

Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO., PMID:29997207

From recognition to execution-the HCMV Pentamer from receptor binding to fusion triggering., PMID:29866439

CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells., PMID:29739904

False human cytomegalovirus IgG-positivity at prenatal screening., PMID:29705613

Fine Mapping the Interaction Between Dendritic Cell-Specific Intercellular Adhesion Molecule (ICAM)-3-Grabbing Nonintegrin and the Cytomegalovirus Envelope Glycoprotein B., PMID:29648611

Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection., PMID:29088734

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

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For research use only. Not for human or drug use.

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InVivoMAb Anti-HCMV/HHV5 gH/UL75 Antibody (Iv0180) [VVV05101]
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