Catalog No.
PHD62901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human GADD45A (Met1-Arg165).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
DNA damage-inducible transcript 1 protein,GADD45,DDIT1,GADD45A,Growth arrest and DNA damage-inducible protein GADD45 alpha,DDIT-1
Purification
Purified by antigen affinity column.
Accession
P24522
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
NPS-1034 Exerts Therapeutic Efficacy in Renal Cell Carcinoma Through Multiple Targets of MET, AXL, and TNFRSF1A Signaling in a Metastatic Model., PMID:39451232
Analysis and experimental validation of IL-17 pathway and key genes as central roles associated with inflammation in hepatic ischemia-reperfusion injury., PMID:38494504
Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology., PMID:36129033
Molecular Response to Combined Molecular- and External Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC)., PMID:34830750
CEACAM3 decreases asthma exacerbations and modulates respiratory syncytial virus latent infection in children., PMID:32606071
Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells., PMID:32597148
Genome-Wide Association Study Identifies Genomic Loci Associated With Neurotransmitter Concentration in Cattle., PMID:32292413
GADD45a and GADD45b Genes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients., PMID:31195707
A whole-blood RNA transcript-based gene signature is associated with the development of CTLA-4 blockade-related diarrhea in patients with advanced melanoma treated with the checkpoint inhibitor tremelimumab., PMID:30227886
Stress-induced release of Oct-1 from the nuclear envelope is mediated by JNK phosphorylation of lamin B1., PMID:28542436
SjCa8, a calcium-binding protein from Schistosoma japonicum, inhibits cell migration and suppresses nitric oxide release of RAW264.7 macrophages., PMID:26445908
Exploring the genes associated with the response to intravenous immunoglobulin in patients with Kawasaki disease using DNA microarray analysis., PMID:25449331
Gadd45a regulates hematopoietic stem cell stress responses in mice., PMID:24371210
Gadd45a levels in human breast cancer are hormone receptor dependent., PMID:23706118
Epigenetic dysregulation in salivary glands from patients with primary Sjögren's syndrome may be ascribed to infiltrating B cells., PMID:23478041
5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis., PMID:22843381
Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT., PMID:21813510
Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells., PMID:20131288
Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia., PMID:19628795
Ligation or cross-linking of CD40 has different effects on AGS gastric cancer cells., PMID:19604505
Inhibitory effect of wild-type p53 gene on excessive replication of centrosomes in leukemia cell line K562., PMID:19550118
Characterization of an alternatively spliced GADD45alpha, GADD45alpha1 isoform, in arsenic-treated epithelial cells., PMID:18942077
Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production., PMID:18849615
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development., PMID:18469817
Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats., PMID:18253720
Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: identification of apoptotic genes as targets for demethylation., PMID:17845729
Gadd45alpha does not modulate the carboplatin or 5-fluorouracil-induced apoptosis in human papillomavirus-positive cells., PMID:17063488
GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure., PMID:12164919
Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome., PMID:11970874
For research use only. Not for human or drug use.
