Catalog No.
PHD49101
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human COMT (Gly52-Pro271).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Catechol O-methyltransferase,COMT
Purification
Purified by antigen affinity column.
Accession
P21964
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Characteristics associated with response to subcutaneously administered anti-CGRP monoclonal antibody medications in a real-world community cohort of persons living with migraine: A retrospective clinical and genetic study., PMID:38071464
[Development of disease-modifying drugs for Parkinson's disease. Is it a tough road?]., PMID:36990797
A Self-Reinforcing Nanoplatform for Highly Effective Synergistic Targeted Combinatary Calcium-Overload and Photodynamic Therapy of Cancer., PMID:36640265
Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor α Axis., PMID:36623778
Toxoplasma gondii Seropositivity Interacts with Catechol-O-methyltransferase Val105/158Met Variation Increasing the Risk of Schizophrenia., PMID:35741850
Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L., PMID:35550086
Label-free LC-HRMS-based enzymatic activity assay for the detection of DDC, MAO and COMT inhibitors., PMID:35152005
Targeting COVID-19 in Parkinson's Patients: Drugs Repurposed., PMID:32881656
Learning from amyloid trials in Alzheimer's disease. A virtual patient analysis using a quantitative systems pharmacology approach., PMID:32255562
A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression., PMID:31029013
Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation., PMID:29935309
A pilot study on commonality and specificity of copy number variants in schizophrenia and bipolar disorder., PMID:27244233
Biological aspects and candidate biomarkers for psychotic bipolar disorder: A systematic review., PMID:26969211
Application of Various Statistical Models to Explore Gene-Gene Interactions in Folate, Xenobiotic, Toll-Like Receptor and STAT4 Pathways that Modulate Susceptibility to Systemic Lupus Erythematosus., PMID:26689915
PKCε as a novel promoter of skeletal muscle differentiation and regeneration., PMID:26431586
Polymorphism in COMT is associated with IgG3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome., PMID:26272340
Inhibition of catechol-O-methyl transferase (COMT) by tolcapone restores reductions in microtubule-associated protein 2 (MAP2) and synaptophysin (SYP) following exposure of neuronal cells to neurotropic HIV., PMID:26037113
A longitudinal study of cognitive functioning in schizophrenia: clinical and biological predictors., PMID:24827555
Association of genetic variants of xenobiotic metabolic pathway with systemic lupus erythematosus., PMID:24772967
β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines., PMID:24727346
Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome?, PMID:24503977
Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity., PMID:24465277
Diversified expression of NG2/CSPG4 isoforms in glioblastoma and human foetal brain identifies pericyte subsets., PMID:24386429
Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes., PMID:23010222
Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice., PMID:22658921
Levamisole in cocaine: unexpected news from an old acquaintance., PMID:22455354
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors., PMID:21974969
Comparison of endothelial progenitor cells in Parkinson's disease patients treated with levodopa and levodopa/COMT inhibitor., PMID:21738693
Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice., PMID:20374420
Membrane-Bound Catechol-O-Methyl Transferase in Cortical Neurons and Glial Cells is Intracellularly Oriented., PMID:21423451
Analysis of prepulse inhibition in mouse lines overexpressing 22q11.2 orthologues., PMID:19519974
Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip)., PMID:19225952
Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder., PMID:18571372
Aniseed-induced nocturnal tongue angioedema., PMID:18088024
A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases., PMID:18028865
Characterization of a caffeic acid 3-O-methyltransferase from wheat and its function in lignin biosynthesis., PMID:17976886
Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia., PMID:17240060
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder., PMID:16542182
Human catechol-O-methyltransferase down-regulation by estradiol., PMID:14573393
Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses., PMID:12150502
Identification of a Manduca sexta NSF ortholog, a member of the AAA family of ATPases., PMID:10580154
Increase of catechol-O-methyltransferase activity in rat brain microglia after intrastriatal infusion of fluorocitrate, a glial toxin., PMID:9272684
Methyl jasmonate induces an O-methyltransferase in barley., PMID:9297848
Aromatase and estrogen 2-hydroxylase activities of human placental microsomes in pregnancy-induced hypertension., PMID:8930523
The Vpreb1 and comt genes are closely linked and sublocalized to rat chromosome 11q23., PMID:9162259
Catechol-O-methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein., PMID:7617303
Distribution of catechol-O-methyltransferase enzyme in rat tissues., PMID:8027527
Catechol O-methyltransferase pharmacogenetics: photoaffinity labelling and western blot analysis of human liver samples., PMID:8518836
Immunoaffinity purification and partial amino acid sequence analysis of catechol-O-methyltransferase from pig liver., PMID:1932084
Stress Responses in Alfalfa (Medicago sativa L.): X. Molecular Cloning and Expression of S-Adenosyl-l-Methionine:Caffeic Acid 3-O-Methyltransferase, a Key Enzyme of Lignin Biosynthesis., PMID:16668418
For research use only. Not for human or drug use.
