Anti-CD72 Polyclonal Antibody

Catalog No.

PHD48301

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD72 (Glu169-Asp359).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

CD72,Lyb-2,B-cell differentiation antigen CD72

Purification

Purified by antigen affinity column.

Accession

P21854

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody., PMID:38754236

A phase 1/2 study of pepinemab in children, adolescents, or young adults with recurrent or refractory solid tumors: A children's oncology group consortium report (ADVL1614)., PMID:38520670

Oncolytic attenuated measles virus encoding NY-ESO-1 induces HLA I and II presentation of this tumor antigen by melanoma and dendritic cells., PMID:37466668

AGE-DEPENDENT IMMUNE STATUS CHANGES IN CHRONIC PANCREATITIS PATIENTS., PMID:36427842

Regulation of B cell receptor signalling by Epstein-Barr virus nuclear antigens., PMID:36383217

Blockage of CD72 reduces B cell proliferation in immune thrombocytopenic purpura, involving interleukin 1 and macrophage migration inhibitory factor secretion., PMID:36326455

Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis., PMID:35328359

Role of inhibitory B cell co-receptors in B cell self-tolerance to non-protein antigens., PMID:34989000

Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts., PMID:34113352

A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome., PMID:32306893

CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model., PMID:31262443

Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation., PMID:30930899

Ligand Recognition Determines the Role of Inhibitory B Cell Co-receptors in the Regulation of B Cell Homeostasis and Autoimmunity., PMID:30333834

A platform for phenotypic discovery of therapeutic antibodies and targets applied on Chronic Lymphocytic Leukemia., PMID:30182064

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells., PMID:30005826

T Cell-Dependent Affinity Maturation and Innate Immune Pathways Differentially Drive Autoreactive B Cell Responses in Rheumatoid Arthritis., PMID:29855173

Trib1 Is Overexpressed in Systemic Lupus Erythematosus, While It Regulates Immunoglobulin Production in Murine B Cells., PMID:29599769

Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen., PMID:29321445

Semaphorin 4D from CD15+ Granulocytes via ADAM10-Induced Cleavage Contributes to Antibody Production in Bullous Pemphigoid., PMID:29054606

Retention and topology of the bovine viral diarrhea virus glycoprotein E2., PMID:28874234

Intact CD100-CD72 Interaction Necessary for TCR-Induced T Cell Proliferation., PMID:28713384

COMPARATIVE CHARACTERISTICS OF IMMUNE STATUS OF PATIENTS WITH CHRONIC FORMS OF VIRAL HEPATITIS B, C, D AND HEALTHY INDIVIDUALS., PMID:30695543

CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP., PMID:27810925

Immunomodulation of inflammatory leukocyte markers during intravenous immunoglobulin treatment associated with clinical efficacy in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:27781132

Evidence for the existence of regulatory and effector B cell populations in Peyer's patches of sheep., PMID:27185260

Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis., PMID:26883681

[CD22 and CD72 are inhibitory receptors dominantly expressed in B lymphocytes and regulate systemic autoimmune diseases. German version]., PMID:26830296

The role of Sema4D/CD100 as a therapeutic target for tumor microenvironments and for autoimmune, neuroimmune and bone diseases., PMID:26732941

Bone marrow and splenic histology in hairy cell leukaemia., PMID:26614898

Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis., PMID:25516754

CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα., PMID:25239131

Molecular landscape of T cell-mediated rejection in human kidney transplants: prominence of CTLA4 and PD ligands., PMID:25219326

Interaction of CD5 and CD72 is involved in regulatory T and B cell homeostasis., PMID:24950378

[Effect of proteflazid on TLRs expression by mononuclear leukocytes of peripheral blood and epithelial cells of mucous membranes and skin in patients with herpes-associated erythema multiforme and erythema annulare centrifugum]., PMID:24800523

[Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]., PMID:24605681

A regulatory role for CD72 expression on B cells in systemic lupus erythematosus., PMID:24461079

Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease., PMID:23616572

A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus mice., PMID:23365086

CD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1., PMID:24713856

Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum., PMID:23268649

Modulation of B cell regulatory molecules CD22 and CD72 in myasthenia gravis and multiple sclerosis., PMID:23184497

[Mast cell regulation]., PMID:22868520

Role of inhibitory BCR co-receptors in immunity., PMID:22394175

Immunophenotyping of classic murine myeloma cell lines used for monoclonal antibody production., PMID:22316479

Peripheral blood lymphocytes analysis detects CD100/SEMA4D alteration in systemic sclerosis patients., PMID:21244334

[Therapeutic bacterial vaccine Immunovac in complex treatment of patients with chronic pyoderma]., PMID:20795383

CD72 negatively regulates KIT-mediated responses in human mast cells., PMID:20100931

Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner., PMID:19454653

Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection., PMID:19258515

CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function., PMID:19067131

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