Anti-SYT1 Polyclonal Antibody

Catalog No.

PHD46301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SYT1 (Glu136-Lys422).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

SytI,Synaptotagmin I,p65,Synaptotagmin-1,SVP65,SYT1,SYT

Purification

Purified by antigen affinity column.

Accession

P21579

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

A guide to selecting high-performing antibodies for Synaptotagmin-1 (Uniprot ID P21579) for use in western blot, immunoprecipitation, immunofluorescence and flow cytometry., PMID:39169954

Mangiferin depresses vesicular glutamate release in synaptosomes from the rat cerebral cortex by decreasing synapsin I phosphorylation., PMID:37146708

Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B+ vesicle pathway in liver cancer., PMID:36044553

Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release., PMID:35361702

Comparative systeomics to elucidate physiological differences between CHO and SP2/0 cell lines., PMID:35228567

Annexin A2 Flop-Out Mediates the Non-Vesicular Release of DAMPs/Alarmins from C6 Glioma Cells Induced by Serum-Free Conditions., PMID:33807671

Unique dynamics and exocytosis properties of GABAergic synaptic vesicles revealed by three-dimensional single vesicle tracking., PMID:33622785

Synaptotagmin 1 Is Involved in Neuropathic Pain and Electroacupuncture-Mediated Analgesic Effect., PMID:32024024

Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis., PMID:30038018

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins., PMID:30010661

Targeting Phosphatidylserine with Calcium-Dependent Protein-Drug Conjugates for the Treatment of Cancer., PMID:28939556

Arabidopsis SYT1 maintains stability of cortical endoplasmic reticulum networks and VAP27-1-enriched endoplasmic reticulum-plasma membrane contact sites., PMID:27811083

Antisera against Neisseria gonorrhoeae cross-react with specific brain proteins of the common marmoset monkey and other nonhuman primate species., PMID:27765579

Synaptic vesicle pool-specific modification of neurotransmitter release by intravesicular free radical generation., PMID:27723113

Presynaptic protein Synaptotagmin1 regulates the neuronal polarity and axon differentiation in cultured hippocampal neurons., PMID:26667128

Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1., PMID:26400647

BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons., PMID:25426063

Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen., PMID:22398727

New candidate proteins for benzo(a)pyrene-induced spatial learning and memory deficits., PMID:21467743

Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p., PMID:20841378

Cholesterol reduction impairs exocytosis of synaptic vesicles., PMID:20103534

Deferoxamine-induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures., PMID:19581022

Calcium-dependent freezing tolerance in Arabidopsis involves membrane resealing via synaptotagmin SYT1., PMID:19088330

The dystonia-associated protein torsinA modulates synaptic vesicle recycling., PMID:18167355

JunB is required for IgE-mediated degranulation and cytokine release of mast cells., PMID:17982078

Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidentical., PMID:16845386

Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells., PMID:16386321

An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission., PMID:15721242

Lambert-Eaton myasthenic syndrome as an autoimmune calcium channelopathy., PMID:15336982

Distribution of the presynaptic calcium sensors, synaptotagmin I/II and synaptotagmin III, in the goldfish and rodent retinas., PMID:12803536

Palmitoylation sites and processing of synaptotagmin I, the putative calcium sensor for neurosecretion., PMID:12782290

Morphological and molecular heterogeneity in release sites of single neurons., PMID:12713639

Differential distribution of synaptotagmin immunoreactivity among synapses in the goldfish, salamander, and mouse retina., PMID:12699082

Synaptotagmin I and IV are differentially regulated in the brain by the recreational drug 3,4-methylenedioxymethamphetamine (MDMA)., PMID:12480182

Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells., PMID:12388083

The C-terminal domain of pancreatic lipase: functional and structural analogies with c2 domains., PMID:12369922

SNAP-25 and synaptotagmin 1 function in Ca2+-dependent reversible docking of granules to the plasma membrane., PMID:12047557

Synaptotagmin I-DeltaC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla., PMID:11988182

Expression of synaptotagmin I or II promotes neurite outgrowth in PC12 cells., PMID:11078930

Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis., PMID:10868959

SNAREs in mammalian sperm: possible implications for fertilization., PMID:10864460

Membrane-embedded synaptotagmin penetrates cis or trans target membranes and clusters via a novel mechanism., PMID:10840045

Synaptotagmin I and IV define distinct populations of neuronal transport vesicles., PMID:10762358

Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels., PMID:10737807

Lambert-Eaton myasthenic syndrome as an autoimmune calcium-channelopathy., PMID:10683522

Role of synaptotagmin, a Ca2+ and inositol polyphosphate binding protein, in neurotransmitter release and neurite outgrowth., PMID:10358928

Isolation of synaptotagmin as a receptor for types A and E botulinum neurotoxin and analysis of their comparative binding using a new microtiter plate assay., PMID:9783260

Characterization of Clostridium botulinum type B neurotoxin associated with infant botulism in japan., PMID:9746583

Visualization of cyclic AMP-regulated presynaptic activity at cerebellar granule cells., PMID:9581768

Exocytotic proteins in enterochromaffin-like (ECL) cells of the rat stomach., PMID:9369530

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