Catalog No.
FHC10910
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, Heme-binding membrane glycoprotein gp91phox, Neutrophil cytochrome b 91 kDa polypeptide, gp91-phox, NOX2, Cytochrome b-245 heavy chain, p22 phagocyte B-cytochrome, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, NADPH oxidase 2, CYBB, CGD91-phox
Concentration
0.89 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P04839
Applications
FCM, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0847
Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation., PMID:40226614
Oxidative/Nitrosative Stress and Brain Involvement in Sepsis: A Relationship Supported by Immunohistochemistry., PMID:39768830
Integrated bioinformatic analysis of the shared molecular mechanisms between ANCA-associated vasculitis and atherosclerosis., PMID:39702436
Mechanisms of Mt.b Ag85B-Fc fusion protein against allergic asthma in mice by intranasal immunization., PMID:39549815
Identification and experimental validation of genes associated with programmed cell death in dendritic cells of the thyroid tissue in Hashimoto's thyroiditis., PMID:39260305
Profile of juvenile systemic lupus erythematosus patients with a special reference to monogenic lupus and lupus nephritis: a cross-sectional study., PMID:39180524
Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes., PMID:39046281
Nrf2, gp91phox and IL-17 are associated with severity and clinical outcomes of patients with subclinical hypothyroidism: a comparative study., PMID:39033335
Clinical features and lymphocyte immunophenotyping analysis in primary immunodeficiency patients with non-transplant lymphoproliferative disorders., PMID:38838929
Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma., PMID:38292661
BTK inhibition potentiates anti-PD-L1 treatment in murine melanoma: potential role for MDSC modulation in immunotherapy., PMID:37528320
Immunosuppression by Inflammation-Stimulated Amplification of Myeloid-Derived Suppressor Cells and Changes in Expression of Immune Checkpoint HHLA2 in Chronic Obstructive Pulmonary Disease., PMID:36846109
Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism., PMID:36605123
Recent topics and advanced therapies in chronic granulomatous disease., PMID:36534309
The diagnostic potential of novel biomarkers of hypertension in men., PMID:36457990
Structure of the core human NADPH oxidase NOX2., PMID:36241643
Variant Type X91+ Chronic Granulomatous Disease: Clinical and Molecular Characterization in a Chinese Cohort., PMID:35796921
Identification of differentially expressed genes and pathways in kidney of ANCA-associated vasculitis by integrated bioinformatics analysis., PMID:35172670
Fine definition of the epitopes on the human gp91phox/NOX2 for the monoclonal antibodies CL-5 and 48., PMID:34971634
Identification and Validation of CYBB, CD86, and C3AR1 as the Key Genes Related to Macrophage Infiltration of Gastric Cancer., PMID:34950700
Utility of Immunohistochemistry and Immunofluorescence in Determining the Pathogenic Variants of Chronic Granulomatous Disease., PMID:34651207
Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency., PMID:34375309
Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors Reduce Platelet Activation Modulating ox-LDL Pathways., PMID:34281247
Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis., PMID:33916948
Analysis of canine myeloid-derived suppressor cells (MDSCs) utilizing fluorescence-activated cell sorting, RNA protection mediums to yield quality RNA for single-cell RNA sequencing., PMID:33278779
Wound Healing After Alkali Burn Injury of the Cornea Involves Nox4-Type NADPH Oxidase., PMID:33079994
Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice., PMID:33042267
Idelalisib Rescues Natural Killer Cells from Monocyte-Induced Immunosuppression by Inhibiting NOX2-Derived Reactive Oxygen Species., PMID:32967913
Chronic Granulomatous Disease with the McLeod Phenotype: a French National Retrospective Case Series., PMID:32562208
Recent advances in chronic granulomatous disease., PMID:32181279
Connexin43 Is Required for the Effective Activation of Spleen Cells and Immunoglobulin Production., PMID:31752090
Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling., PMID:31419440
NOX2 mediates quiescent handling of dead cell remnants in phagocytes., PMID:31349119
B subset cells in patients with chronic granulomatous disease in a Mexican population., PMID:31176517
Phosphorylation of gp91phox/NOX2 in Human Neutrophils., PMID:31172483
The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice., PMID:31151207
A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice., PMID:31004013
Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair., PMID:30842418
[Viewing sepsis and autoimmune disease in relation with infection and NETs-formation]., PMID:29863035
Myeloid peroxisome proliferator-activated receptor gamma deficiency aggravates myocardial infarction in mice., PMID:29800789
Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling., PMID:29688896
BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways., PMID:29623489
Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91phox , phagocyte flavocytochrome b558 large subunit., PMID:29573449
FcγR/ROS/CK2α Is the Key Inducer of NF-κB Activation in a Murine Model of Asthma., PMID:29339659
Role of NADPH oxidase in radiation-induced pro-oxidative and pro-inflammatory pathways in mouse brain., PMID:28880721
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling., PMID:28801234
X-linked carriers of chronic granulomatous disease: Illness, lyonization, and stability., PMID:28528201
Gp91phox NADPH oxidase modulates litter size by regulating mucin1 in the uterus of mice., PMID:28301257
Excess reactive oxygen species production mediates monoclonal antibody-induced human embryonic stem cell death via oncosis., PMID:28106884
Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation., PMID:27975175
For research use only. Not for human or drug use.
