Anti-HIV1 Surface protein gp120 Nanobody (SAA0912)

Catalog No.

RVV03101

Expression system

Mammalian Cells

Species reactivity

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clonality

Monoclonal

Target

Envelope glycoprotein gp160, Env polyprotein, Surface protein gp120, SU, Glycoprotein 120, gp120, Transmembrane protein gp41, TM, Glycoprotein 41, gp41, env

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P04578

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA0912

Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site., PMID:35413243

Domain Organization of Lentiviral and Betaretroviral Surface Envelope Glycoproteins Modeled with AlphaFold., PMID:34705555

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies., PMID:33871352

Generation of HIV-resistant cells with a single-domain antibody: implications for HIV-1 gene therapy., PMID:33462383

The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1., PMID:27654286

Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36., PMID:24853313

Exceptionally potent and broadly cross-reactive, bispecific multivalent HIV-1 inhibitors based on single human CD4 and antibody domains., PMID:24198429

Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites., PMID:23843638

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120., PMID:23152508

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding., PMID:9334377

Document Download

Anti-HIV1 Surface protein gp120 Nanobody (SAA0912).pdf