Catalog No.
RHJ66301
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
IL-17B receptor, CRL4, IL17RB, Cytokine receptor-like 4, IL-17RB, IL17BR, IL-17 receptor B, Interleukin-17B receptor, EVI27, Interleukin-17 receptor B, IL17Rh1, IL-17Rh1, IL-17 receptor homolog 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
Q9NRM6
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1267
IL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor., PMID:39829150
Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial., PMID:39717777
Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS)., PMID:39711167
Targeting Ikaros and Aiolos: reviewing novel protein degraders for the treatment of multiple myeloma, with a focus on iberdomide and mezigdomide., PMID:39054911
IL-25 induces airway remodeling in asthma by orchestrating the phenotypic changes of epithelial cell and fibrocyte., PMID:37635231
Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation., PMID:36288706
Dietary antigens suppress the proliferation of type 2 innate lymphoid cells by restraining homeostatic IL-25 production., PMID:35523930
Active Humoral Response Reverts Tumorigenicity through Disruption of Key Signaling Pathway., PMID:35214622
Expression and activity of IL-17 receptor subunits in human cutaneous cells as targets for anti-IL-17 therapeutic antibodies., PMID:35062060
Critical role of IL-25-ILC2-IL-5 axis in the production of anti-Francisella LPS IgM by B1 B cells., PMID:34449811
IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE., PMID:34264790
Identification of Novel Serological Autoantibodies in Takayasu Arteritis Patients Using HuProt Arrays., PMID:33545363
The role of peripheral type 2 innate lymphoid cells in bronchiolitis., PMID:33514798
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade., PMID:33483337
Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses., PMID:33455090
Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer., PMID:33082357
Detection of Cytokine Receptors Using Tyramide Signal Amplification for Immunofluorescence., PMID:31939172
ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions., PMID:31823769
Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion., PMID:30238872
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3., PMID:30013031
IL-25 promotes Th2 bias by upregulating IL-4 and IL-10 expression of decidual γδT cells in early pregnancy., PMID:29434775
The IL-17B-IL-17 receptor B pathway promotes resistance to paclitaxel in breast tumors through activation of the ERK1/2 pathway., PMID:29371916
Cisplatin inhibits the growth, migration and invasion of cervical cancer cells by down-regulating IL-17E/IL-17RB., PMID:31966806
Chemotherapy treatment induces an increase of autophagy in the luminal breast cancer cell MCF7, but not in the triple-negative MDA-MB231., PMID:28775276
Allergic inflammation is exacerbated by allergen-induced type 2 innate lymphoid cells in a murine model of allergic rhinitis., PMID:28689218
Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines., PMID:28624391
Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function., PMID:28620392
IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling., PMID:28421819
The TH2-polarizing function of atopic interleukin 17 receptor B-positive dendritic cells up-regulated by lipopolysaccharide., PMID:28132739
IL-17RB+ granulocytes are associated with airflow obstruction in asthma., PMID:27979026
Mucosal Expression of T Cell Gene Variants Is Associated with Differential Resistance to Teladorsagia circumcincta., PMID:27973603
Immune analysis of expression of IL-17 relative ligands and their receptors in bladder cancer: comparison with polyp and cystitis., PMID:27716046
Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics., PMID:27685606
IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy., PMID:26560039
Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines., PMID:25732306
Interleukin-25 induced by human chorionic gonadotropin promotes the proliferation of decidual stromal cells by activation of JNK and AKT signal pathways., PMID:24746746
IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease., PMID:24407884
Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway., PMID:23851503
The role of interleukin 17 in Crohn's disease-associated intestinal fibrosis., PMID:23834907
Interleukin-25 promotes basic fibroblast growth factor expression by human endothelial cells through interaction with IL-17RB, but not IL-17RA., PMID:23106660
Interleukin-17F affects cartilage matrix turnover by increasing the expression of collagenases and stromelysin-1 and by decreasing the expression of their inhibitors and extracellular matrix components in chondrocytes., PMID:21885294
The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex., PMID:21473777
IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo., PMID:20392496
Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses., PMID:19400908
A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity., PMID:19015310
For research use only. Not for human or drug use.
