Catalog No.
RHC83401
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Alpaca
Isotype
VHH-8His-Cys-tag
Clonality
Monoclonal
Target
CD28, TP44, T-cell-specific surface glycoprotein CD28
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
P10747
Applications
ELISA, FCM, SPR
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1283
Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction., PMID:38737794
Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22., PMID:38596311
Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell., PMID:38178096
CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models., PMID:37924157
The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer., PMID:37031249
Human VH-based chimeric antigen receptor T cells targeting glypican 3 eliminate tumors in preclinical models of HCC., PMID:36691969
T cell engineered with a novel nanobody-based chimeric antigen receptor against VEGFR2 as a candidate for tumor immunotherapy., PMID:30724452
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity., PMID:30076299
Screening and antitumor effect of an anti‑CTLA‑4 nanobody., PMID:29207143
Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors., PMID:27548616
Development and validation of an LC-MS/MS assay for the quantitation of a PEGylated anti-CD28 domain antibody in human serum: overcoming interference from antidrug antibodies and soluble target., PMID:25384590
T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: towards tumor-directed oligoclonal T cell therapy., PMID:24076235
Antagonist properties of monoclonal antibodies targeting human CD28: role of valency and the heavy-chain constant domain., PMID:23221503
Genetically engineered T cells bearing chimeric nanoconstructed receptors harboring TAG-72-specific camelid single domain antibodies as targeting agents., PMID:22902507
Nanobody-based chimeric receptor gene integration in Jurkat cells mediated by φC31 integrase., PMID:21906589
Anti-MUC1 nanobody can redirect T-body cytotoxic effector function., PMID:19249993
A method for constructing reshaping single-domain antibody., PMID:12182069
For research use only. Not for human or drug use.
