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Anti-Human EGFR/ERBB1/HER1 Nanobody (SAA1213)

Catalog #:   RHB86905 Specific References (50) DATASHEET
Host species: Alpaca
Isotype: VHH-8His-Cys-tag
Applications: ELISA, FCM, SPR
Expression system: Mammalian Cells
Overview

Catalog No.

RHB86905

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Alpaca

Isotype

VHH-8His-Cys-tag

Clonality

Monoclonal

Target

HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P00533

Applications

ELISA, FCM, SPR

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1213

Data Image
  • SDS-PAGE
    SDS PAGE for Human EGFR/ERBB1/HER1 Nanobody
References

[Targeted therapy for colorectal cancer through miR-204-5p delivered by nanobody-engineered exosomes: an experimental study]., PMID:40375589

Nanobody-based immunotoxins: A precision tool in the treatment of solid tumors., PMID:40347884

Efficient Tumor-Targeted Photosensitizer Based on Nanobody-Coupled Pyropheophorbide-a for Precise Photodynamic Therapy of Tumors., PMID:40298399

Protein Nanoparticles Simultaneously Displaying TRAIL and EGFR-Binding Ligands Effectively Induce Apoptotic Cancer Cell Death and Overcome EGFR-TKI Resistance in Lung Cancer., PMID:40237189

Publisher Correction: Presence of EGF ligand restricts the binding ability of EgB4 nanobody to EGFR extracellular domain., PMID:40185852

Q-TWiST Analysis of Sacituzumab Govitecan vs. Chemotherapy in Previously Treated Patients with HR+/HER2- Metastatic Breast Cancer., PMID:40136373

The generation of a novel HER2-targeting nano PE25 immunotoxin with superior anti-tumor activity and high productivity., PMID:40086588

Her-2 nanobody modified cisplatin nanoparticles for precise chemotherapy of colon cancer., PMID:39976420

Development of Top-Down Mass Spectrometry Strategies in the Chromatographic Time Scale (LC-TD-MS) for the Extended Characterization of an Anti-EGFR Single-Domain Antibody-Drug Conjugate in Both Reduced and Nonreduced Forms., PMID:39889214

A HER2 Specific Nanobody-Drug Conjugate: Site-Selective Bioconjugation and In Vitro Evaluation in Breast Cancer Models., PMID:39860260

Presence of EGF ligand restricts the binding ability of EgB4 nanobody to EGFR extracellular domain., PMID:39827297

Decoupling Individual Host Response and Immune Cell Engager Cytotoxic Potency., PMID:39791371

Correction for van de Water et al., Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects., PMID:39786944

Radiolabeled HER2-targeted molecular probes in breast cancer imaging: current knowledge and future prospective., PMID:39751821

Identification of the Pharmacological Components and Its Targets of Sanghuang by Integration of Nontarget Metabolomics and Network Pharmacology Analysis., PMID:39748251

Comparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups., PMID:39680709

Nanobodies' duo facilitates ultrasensitive serum HER-2/neu immunoassays via enhanced avidity interactions., PMID:39643321

Reconstituting the immune killing functions and improving the pharmacokinetics of nanobodies by rhamnolipid conjugation., PMID:39637990

Editorial Note: Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling., PMID:39630016

Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib-Resistant Non-Small Cell Lung Cancer., PMID:39586988

Functional evaluation of circulating anti-cancer antibodies with a 3D tumor cell growth inhibition assay., PMID:39515883

Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years., PMID:39455963

Programmable Circular Multivalent Nanobody-Targeting Chimeras (mNbTACs) for Multireceptor-Mediated Protein Degradation and Targeted Drug Delivery., PMID:39402961

Bacterial Living Therapeutics with Engineered Protein Secretion Circuits to Eliminate Breast Cancer Cells., PMID:39367855

Correction for van de Water et al., Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects., PMID:39348549

Analysis of EGFR binding hotspots for design of new EGFR inhibitory biologics., PMID:39275996

Chemo-Enzymatic Functionalization of Bovine Milk Exosomes with an EGFR Nanobody for Target-specific Drug Delivery., PMID:39192477

Imaging and Monitoring HER2 Expression in Tumors during HER2 Antibody-Drug Conjugate Therapy Utilizing a Radiolabeled Site-Specific Single-Domain Antibody Probe: 68Ga-NODAGA-SNA004-GSC., PMID:39077778

Dual-Targeting of the HER2 Cancer Receptor with an Antibody-Directed Enzyme and a Nanobody-Guided MMAE Prodrug Scaffold., PMID:38945824

Structural insights into the role and targeting of EGFRvIII., PMID:38908376

Comparative study of optical fiber immunosensors based on traditional antibody or nanobody for detecting HER2., PMID:38810383

Emerging paradigms and recent progress in targeting ErbB in cancers., PMID:38797570

Kinase Inhibitors and Kinase-Targeted Cancer Therapies: Recent Advances and Future Perspectives., PMID:38791529

Non-Invasive Delivery of Negatively Charged Nanobodies by Anodal Iontophoresis: When Electroosmosis Dominates Electromigration., PMID:38675200

Molecular and functional insight into anti-EGFR nanobody: Theranostic implications for malignancies., PMID:38554946

Nanobody-mediated targeting of zinc phthalocyanine with polymer micelles as nanocarriers., PMID:38492899

Molecular probes targeting HER2 PET/CT and their application in advanced breast cancer., PMID:38466436

Detection of HER2 expression using 99mTc-NM-02 nanobody in patients with breast cancer: a non-randomized, non-blinded clinical trial., PMID:38459598

NSCLC: from tumorigenesis, immune checkpoint misuse to current and future targeted therapy., PMID:38384472

Chimeric nanobody-decorated liposomes by self-assembly., PMID:38374413

Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers., PMID:38372053

Multivalent Rhamnose-Modified EGFR-Targeting Nanobody Gains Enhanced Innate Fc Effector Immunity and Overcomes Cetuximab Resistance via Recruitment of Endogenous Antibodies., PMID:38286668

Erratum: Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging: Erratum., PMID:38250047

An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation., PMID:38231391

Reprogramming tumor-associated macrophages by a dually targeted milk exosome system as a potent monotherapy for cancer., PMID:38184235

Small Antibodies with Big Applications: Nanobody-Based Cancer Diagnostics and Therapeutics., PMID:38067344

An off-the-shelf small extracellular vesicle nanomedicine for tumor targeting therapy., PMID:37967724

A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells., PMID:37954614

Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins., PMID:37899626

Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids., PMID:37896133

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

Contact Information

Order: order@antibodysystem.com

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Distributor list

For research use only. Not for human or drug use.

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Anti-Human EGFR/ERBB1/HER1 Nanobody (SAA1213) [RHB86905]
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