Catalog No.
PHA39501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human KDM6B (Pro1186-Arg1643).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
JMJD3, [histone H3]-trimethyl-L-lysine(27) demethylase 6B, Jumonji domain-containing protein 3, KDM6B, JmjC domain-containing protein 3, KIAA0346, Lysine demethylase 6B, Lysine-specific demethylase 6B
Purification
Purified by antigen affinity column.
Accession
O15054
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Identification of novel autoantibodies in Sjögren's disease., PMID:39963128
Decreased Jumonji Domain-Containing 3 at the Promoter Downregulates Hematopoietic Progenitor Kinase 1 Expression and Cytoactivity of T Follicular Helper Cells from Systemic Lupus Erythematosus Patients., PMID:36213329
Dynamics of epigenetic modifiers and environmentally sensitive proteins in a reptile with temperature induced sex reversal†., PMID:34849582
Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model., PMID:34275493
RETRACTED: KDM4A promotes the growth of non-small cell lung cancer by mediating the expression of Myc via DLX5 through the Wnt/β-catenin signaling pathway., PMID:33002480
Reduced H3K27me3 levels in diffuse gliomas: association with 1p/19q codeletion and difference from H3K27me3 loss in malignant peripheral nerve sheath tumors., PMID:32989606
Immunity and autoantibodies of a mouse strain with autistic-like behavior., PMID:34589851
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice., PMID:31971317
The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic silencing of the wwc1 gene, a Hippo/YAP pathway upstream effector, in breast cancer epithelial cells., PMID:30121333
Long non-coding RNA SNHG14 induces trastuzumab resistance of breast cancer via regulating PABPC1 expression through H3K27 acetylation., PMID:30063126
Jumonji domain-containing protein 3 regulates the early inflammatory response epigenetically in human periodontal ligament cells., PMID:29859500
TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17., PMID:29563337
Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment., PMID:29559448
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs., PMID:27742770
MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection., PMID:27532872
Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST., PMID:26645727
Histone H3k9 and H3k27 Acetylation Regulates IL-4/STAT6-Mediated Igε Transcription in B Lymphocytes., PMID:25952120
Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells., PMID:24572572
PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer., PMID:23714854
Configuration of a high-content imaging platform for hit identification and pharmacological assessment of JMJD3 demethylase enzyme inhibitors., PMID:22223398
Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus., PMID:22014533
Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma., PMID:21810159
Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development., PMID:20833714
For research use only. Not for human or drug use.
