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Research Grade Tositumomab

Catalog #:   DHC90709 Specific References (98) DATASHEET
Host species: Mouse
Isotype: IgG2a-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC90709

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a-lambda

Clonality

Monoclonal

Target

B-lymphocyte surface antigen B1, Membrane-spanning 4-domains subfamily A member 1, MS4A1, Leukocyte surface antigen Leu-16, B-lymphocyte antigen CD20, Bp35, CD20

Concentration

2.14 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P11836

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAS: 208921-02-2

Clone ID

Tositumomab

Data Image
  • SDS-PAGE
    SDS PAGE for Tositumomab
References

Tositumomab, PMID: 31643663

I-131 tositumomab, PMID: 20590521

Tositumomab I 131, PMID: 29999771

Tositumomab and (131)I therapy in non-Hodgkin's lymphoma, PMID: 15653661

131 I-Tositumomab, PMID: 20641455

Iodine-131 tositumomab (Bexxar): radioimmunoconjugate therapy for indolent and transformed B-cell non-Hodgkin's lymphoma, PMID: 14748653

131I tositumomab, PMID: 18034570

A clinical and scientific overview of tositumomab and iodine I 131 tositumomab, PMID: 12728404

Tositumomab and iodine I 131 tositumomab (Bexaar), PMID: 21436340

The clinical importance of dosimetry in radioimmunotherapy with tositumomab and iodine I 131 tositumomab, PMID: 12728405

Iodine 131 tositumomab in the treatment of non-Hodgkin's lymphoma, PMID: 17547519

A review of tositumomab and I(131) tositumomab radioimmunotherapy for the treatment of follicular lymphoma, PMID: 15934835

Targeted Radionuclide Therapy: A Historical and Personal Review, PMID: 31843064

Tositumomab and iodine [131I] tositumomab in the management of follicular lymphoma. An oncologist's view, PMID: 15640794

Iodine-131 tositumomab (Bexxar) in a radiation oncology environment, PMID: 16979436

Dosimetry in patients with B-cell lymphoma treated with [(90)Y]ibritumomab tiuxetan or [(131)I]tositumomab, PMID: 21386787

I-Tositumomab in lymphoma, PMID: 19862360

Cutaneous Adverse Events of Targeted Therapies for Hematolymphoid Malignancies, PMID: 28918995

Initial Experience with Tositumomab and I-131-Labeled Tositumomab for Treatment of Relapsed/Refractory Hodgkin Lymphoma, PMID: 27798787

Development of 131I-tositumomab, PMID: 15786026

131I-tositumomab therapy as initial treatment for follicular lymphoma, PMID: 15689582

Radioimmunotherapy with tositumomab and iodine-131 tositumomab for low-grade non-Hodgkin lymphoma: nursing implications, PMID: 15547634

Radioimmunotherapy for B-cell lymphoma: Y90 ibritumomab tiuxetan and I(131) tositumomab, PMID: 17530015

Feasibility and safety of outpatient Bexxar therapy (tositumomab and iodine I 131 tositumomab) for non-Hodgkin's lymphoma based on radiation doses to family members, PMID: 11779293

Iodine-131 Tositumomab: (131)I-anti-B1 antibody, (131)I-tositumomab, anti-CD20 murine monoclonal antibody-I-131, B1, Bexxar, (131)I-anti-B1 antibody, iodine-131 tositumomab, iodine-131 anti-B1 antibody, tositumomab, PMID: 12899647

Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19, PMID: 33131530

Comparison of 90Y-ibritumomab tiuxetan and 131I-tositumomab in clinical practice, PMID: 17942813

Observational Retrospective Study of Altered Biodistribution of Tositumomab and 131I-Tositumomab, PMID: 26338897

Efficacy and safety of tositumomab and iodine-131 tositumomab (Bexxar) in B-cell lymphoma, progressive after rituximab, PMID: 15613695

Phase 2 Study of Iodine-131 Tositumomab Plus Chemotherapy in Patients With Previously Untreated Mantle-Cell Lymphoma, PMID: 32800518

Cyclophosphamide, vincristine, and prednisone followed by tositumomab and iodine-131-tositumomab in patients with untreated low-grade follicular lymphoma: eight-year follow-up of a multicenter phase II study, PMID: 20458031

Dose-attenuated radioimmunotherapy with tositumomab and iodine 131 tositumomab in patients with recurrent non-Hodgkin's lymphoma (NHL) and extensive bone marrow involvement, PMID: 17325895

Tositumomab and iodine-131 tositumomab produces durable complete remissions in a subset of heavily pretreated patients with low-grade and transformed non-Hodgkin's lymphomas, PMID: 16186600

A phase II trial evaluating the efficacy of high-dose Radioiodinated Tositumomab (Anti-CD20) antibody, etoposide and cyclophosphamide followed by autologous transplantation, for high-risk relapsed or refractory non-hodgkin lymphoma, PMID: 32243637

Phase II trial of CHOP chemotherapy followed by tositumomab/iodine I-131 tositumomab for previously untreated follicular non-Hodgkin's lymphoma: five-year follow-up of Southwest Oncology Group Protocol S9911, PMID: 16896003

The radioisotope contributes significantly to the activity of radioimmunotherapy, PMID: 15585610

131I-tositumomab myeloablative radioimmunotherapy for non-Hodgkin's lymphoma: radiation dose to the testes, PMID: 22955187

Radioimmunotherapy with tositumomab and iodine-131 tositumomab for non-Hodgkin's lymphoma, PMID: 19707321

A practical methodology for patient release after tositumomab and (131)I-tositumomab therapy, PMID: 11884495

Pivotal study of iodine I 131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphomas, PMID: 11579112

131I-tositumomab radioimmunotherapy: initial tumor dose-response results using 3-dimensional dosimetry including radiobiologic modeling, PMID: 20554734

CHOP Chemotherapy Followed by Tositumomab and Iodine-131 Tositumomab for Previously Untreated Diffuse Large B-cell Lymphoma, PMID: 26832194

Tositumomab and iodine I 131 tositumomab for recurrent indolent and transformed B-cell non-Hodgkin's lymphoma, PMID: 15084620

Cancer immunotherapy, PMID: 21355777

Abbreviated chemotherapy with fludarabine followed by tositumomab and iodine I 131 tositumomab for untreated follicular lymphoma, PMID: 16110029

131I tositumomab: a viewpoint by Michael L. Grossbard, PMID: 18034571

The withdrawal of drugs for commercial reasons: the incomplete story of tositumomab, PMID: 25383420

131I-Tositumomab (Bexxar) vs. 90Y-Ibritumomab (Zevalin) therapy of low-grade refractory/relapsed non-Hodgkin lymphoma, PMID: 19543946

Re-treatment with I-131 tositumomab in patients with non-Hodgkin's lymphoma who had previously responded to I-131 tositumomab, PMID: 16204016

Assessment of treatment-related myelodysplastic syndromes and acute myeloid leukemia in patients with non-Hodgkin lymphoma treated with tositumomab and iodine I131 tositumomab, PMID: 15731177

Assessing the Clinical Effectiveness of Radioimmunotherapy with Combined Radionuclide/Monoclonal Antibody Conjugates in Cancer Treatment: Insights from Randomised Clinical Trials., PMID:40361339

Recent preclinical and clinical advances in radioimmunotherapy for non-Hodgkin's lymphoma., PMID:38464386

A Systematic Review of Clinical Applications of Anti-CD20 Radioimmunotherapy for Lymphoma., PMID:38207010

Subclonal TP53 mutations are frequent and predict resistance to radioimmunotherapy in follicular lymphoma., PMID:37379264

Theranostics in Hematooncology., PMID:37290799

Radioimmunotherapy of Non-Hodgkin B-cell Lymphoma: An update., PMID:36635112

Quantitative evaluation of therapy options for relapsed/refractory diffuse large B-cell lymphoma: A model-based meta-analysis., PMID:36470547

Cure of Micrometastatic B-Cell Lymphoma in a SCID Mouse Model Using 213Bi-Anti-CD20 Monoclonal Antibody., PMID:35981897

Immunotherapy in indolent Non-Hodgkin's Lymphoma., PMID:35663281

Construction of miRNA-regulated drug-pathway network to screen drug repurposing candidates for multiple sclerosis., PMID:35356949

Targeted Drug Delivery and Theranostic Strategies in Malignant Lymphomas., PMID:35158894

Dosimetric Approaches for Radioimmunotherapy of Non-Hodgkin Lymphoma in Myeloablative Setting., PMID:34996594

Perspectives on metals-based radioimmunotherapy (RIT): moving forward., PMID:33995659

Bringing Together the Power of T Cell Receptor Mimic and Bispecific Antibodies for Cancer Immunotherapy: Still a Long Way to Go., PMID:33900820

Efficacy and safety of new anti-CD20 monoclonal antibodies versus rituximab for induction therapy of CD20+ B-cell non-Hodgkin lymphomas: a systematic review and meta-analysis., PMID:33547368

Network meta-analysis of targeted therapies for diffuse large B cell lymphoma., PMID:33308179

Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19., PMID:33131530

A phase II trial evaluating the efficacy of high-dose Radioiodinated Tositumomab (Anti-CD20) antibody, etoposide and cyclophosphamide followed by autologous transplantation, for high-risk relapsed or refractory non-hodgkin lymphoma., PMID:32243637

Targeted Radionuclide Therapy: A Historical and Personal Review., PMID:31843064

Radioimmunotherapy in Non-Hodgkin's Lymphoma: Retrospective Adverse Event Profiling of Zevalin and Bexxar., PMID:31546999

Phase 2 Study of Iodine-131 Tositumomab Plus Chemotherapy in Patients With Previously Untreated Mantle-Cell Lymphoma., PMID:32800518

R-CHOP, radioimmunotherapy, and maintenance rituximab in untreated follicular lymphoma (SWOG S0801): a single-arm, phase 2, multicentre study., PMID:29396094

Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016., PMID:29356608

Evaluation of Next-Generation Anti-CD20 Antibodies Labeled with 89Zr in Human Lymphoma Xenografts., PMID:29348316

Cutaneous Adverse Events of Targeted Therapies for Hematolymphoid Malignancies., PMID:28918995

Shifting Focus in the Therapeutics of Immunobullous Disease., PMID:28584371

Whither Radioimmunotherapy: To Be or Not To Be?, PMID:28428282

Initial Experience with Tositumomab and I-131-Labeled Tositumomab for Treatment of Relapsed/Refractory Hodgkin Lymphoma., PMID:27798787

A pioneer experience in Malaysia on In-house Radio-labelling of (131)I-rituximab in the treatment of Non-Hodgkin's Lymphoma and a case report of high dose (131)I-rituximab-BEAM conditioning autologous transplant., PMID:27472826

Emerging antibodies for the treatment of multiple myeloma., PMID:27195659

Consolidative Radioimmunotherapy After Chemoimmunotherapy in Patients With Histologic Transformation of Indolent Non-Hodgkin Lymphoma., PMID:27130328

Safety and efficacy of radioimmunotherapy (RIT) in treatment of non-Hodgkin's lymphoma in the community setting., PMID:27067042

Radioimmunotherapy and Autologous Stem-Cell Transplantation in the Treatment of B-Cell Non-Hodgkin Lymphoma., PMID:26897716

CHOP Chemotherapy Followed by Tositumomab and Iodine-131 Tositumomab for Previously Untreated Diffuse Large B-cell Lymphoma., PMID:26832194

[Ceramide participates in cell programmed death induced by Type II anti-CD20 mAb]., PMID:26739069

Long-term follow-up of previously treated and treatment-naïve patients who received tositumomab and I-131 tositumomab., PMID:26696131

Observational Retrospective Study of Altered Biodistribution of Tositumomab and 131I-Tositumomab., PMID:26338897

Construction and characterization of an anti-CD20 mAb nanocomb with exceptionally excellent lymphoma-suppressing activity., PMID:26257518

Radioimmunotherapy consolidation using 131I-tositumomab for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma in first remission., PMID:26133724

Factors affecting the stability and repeatability of gamma camera calibration for quantitative imaging applications based on a retrospective review of clinical data., PMID:26116127

Low Serum Vitamin D Levels Are Associated With Inferior Survival in Follicular Lymphoma: A Prospective Evaluation in SWOG and LYSA Studies., PMID:25823738

Marrow hypoplasia: a rare complication of untreated Grave's disease., PMID:25627052

Type II anti-CD20 mAb-induced lysosome mediated cell death is mediated through a ceramide-dependent pathway., PMID:25603047

Activatory and inhibitory Fcγ receptors augment rituximab-mediated internalization of CD20 independent of signaling via the cytoplasmic domain., PMID:25568316

Radioimmunoconjugates for the treatment of cancer., PMID:25440606

Ceramide participates in lysosome-mediated cell death induced by type II anti-CD20 monoclonal antibodies., PMID:25393677

The withdrawal of drugs for commercial reasons: the incomplete story of tositumomab., PMID:25383420

Radioimmunotherapy: a specific treatment protocol for cancer by cytotoxic radioisotopes conjugated to antibodies., PMID:25379535

Datasheet

Document Download

Research Grade Tositumomab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Tositumomab [DHC90709]
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