Catalog No.
PHG64203
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human LAMC2 (Leu534-Gln1111).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Laminin subunit gamma-2, Cell-scattering factor 140 kDa subunit, CSF 140 kDa subunit, Epiligrin subunit gamma, Kalinin subunit gamma, Kalinin/nicein/epiligrin 100 kDa subunit, Ladsin 140 kDa subunit, Laminin B2t chain, Laminin-5 subunit gamma, Large adhesive scatter factor 140 kDa subunit, Nicein subunit gamma, LAMC2, LAMB2T, LAMNB2
Purification
Purified by antigen affinity column.
Accession
NP_061486.2
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer., PMID:40121428
Anti-Laminin β4 IgG Drives Tissue Damage in Anti-p200 Pemphigoid and Shows Interactions with Laminin α3 and γ1/2 Chains., PMID:39320300
Using Proteome Microarray and Gene Expression Omnibus Database to Screen Tumour-Associated Antigens to Construct the Optimal Diagnostic Model of Oesophageal Squamous Cell Carcinoma., PMID:37433700
PLAU and LAMC2 can predict a poor prognosis in patients with HNSCC., PMID:37325056
Expression and localization of amelotin, laminin γ2 and odontogenesis-associated phosphoprotein (ODAPH) on the basal lamina and junctional epithelium., PMID:34709488
LAMC2 acts as a novel therapeutic target of cetuximab in laryngeal cancer., PMID:34533031
Risk factors and molecular characterization of penile cancer: impact on prognosis and potential targets for systemic therapy., PMID:31895076
Gene Expression Profiling Reveals Distinct Molecular Subtypes of Esophageal Squamous Cell Carcinoma in Asian Populations., PMID:31048097
Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells., PMID:30485433
Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells., PMID:29604293
Lack of K140 immunoreactivity in junctional epidermolysis bullosa skin and keratinocytes associates with misfolded laminin epidermal growth factor-like motif 2 of the β3 short arm., PMID:28561256
Highly sensitive detection of invasive lung cancer cells by novel antibody against amino-terminal domain of laminin γ2 chain., PMID:27685891
Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes., PMID:26800519
Dermal eosinophilic infiltrate in junctional epidermolysis bullosa., PMID:25950805
MEK/ERK pathway is positively involved in hypoxia-induced vasculogenic mimicry formation in hepatocellular carcinoma which is regulated negatively by protein kinase A., PMID:25487444
Influence of plasma and ultraviolet treatment of zirconia on initial attachment of human oral keratinocytes: expressions of laminin γ2 and integrin β4., PMID:25273051
Influence of ranibizumab treatment on the extracellular matrix in patients with neovascular age-related macular degeneration., PMID:24866589
Laminin-5γ-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration, and invasion by modulating signaling of EGFR., PMID:24170107
Coexistence of pemphigus herpetiformis with IgG antibodies to desmocollin 1 and pemphigoid with IgG antibodies to BP180 C-terminal domain and laminin γ2., PMID:23715433
A laboratory study comparing the effect of ridge exposure using tissue punch versus mucoperiosteal flap on the formation of the implant-epithelial junction., PMID:23083954
Nonscarring skin blistering disease and mucosal lesions with IgA autoantibodies reactive with collagen VII and IgG reactivity with laminin γ2., PMID:22428911
An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis., PMID:22101459
β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness., PMID:22080605
Herlitz junctional epidermolysis bullosa: diagnostic features, mutational profile, incidence and population carrier frequency in the Netherlands., PMID:21801158
Stromal laminin chain distribution in normal, hyperplastic and malignant oral mucosa: relation to myofibroblast occurrence and vessel formation., PMID:19889153
Novel laminin 5 gamma 2-chain fragments potentiating the limbal epithelial cell outgrowth on amniotic membrane., PMID:19420329
Involvement of laminin and integrins in adhesion and migration of junctional epithelium cells., PMID:18973537
Gene symbol: LAMC2. Disease: Epidermolysis Bullosa, Herlitz., PMID:20960622
Metastatic ovarian carcinoma-associated subepidermal blistering disease with autoantibodies to both the p200 dermal antigen and the gamma 2 subunit of laminin 5 showing unusual clinical features., PMID:18294311
Development of a new tracking tool for the human monomeric laminin-gamma 2 chain in vitro and in vivo., PMID:18199549
Laminin-5 immunocytochemistry: a new tool for identifying dysplastic cells in oral brush biopsies., PMID:18031447
Urethral meatal stenosis in junctional epidermolysis bullosa: a rare complication effectively treated with a novel and simple modality., PMID:17910719
Prognostic value of differential expression of Laminin-5 gamma2 in oral squamous cell carcinomas: correlation with survival., PMID:17786338
Bullous pemphigoid positive for anti-BP180 and anti-laminin 5 antibodies in a patient with graft-vs-host disease., PMID:17434049
Overexpression of laminin-5 gamma2 chain in clear cell carcinoma of the ovary., PMID:17235566
A quantitative co-localization analysis of large unspliced tenascin-C(L) and laminin-5/gamma2-chain in basement membranes of oral squamous cell carcinoma by confocal laser scanning microscopy., PMID:17181735
Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjögren's syndrome., PMID:17075843
Coordinate loss of fibroblast growth factor 2 and laminin 5 expression during neoplastic progression of mammary duct epithelium., PMID:16996573
[Blood concentration of laminin gamma2 chain in patients with head and neck cancer]., PMID:16838673
Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1., PMID:16707450
Expression of laminin 5 basement membrane components in invading and recurring adenoid cystic carcinoma of the head and neck., PMID:16332421
Ultrastructural localization of laminin-5 (gamma2 chain) in the rat peri-implant oral mucosa around a titanium-dental implant by immuno-electron microscopy., PMID:15913767
Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration., PMID:15868410
Tumour budding detected by laminin-5 {gamma}2-chain immunohistochemistry is of prognostic value in epidermoid anal cancer., PMID:15821121
Detection of laminin 5-specific auto-antibodies in mucous membrane and bullous pemphigoid sera by ELISA., PMID:15816831
Effectiveness of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid laminin-5 gamma2 chain levels in chronic periodontitis., PMID:15562917
Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids., PMID:15541073
The gamma2 chain of laminin-5 as an indicator of increased risk for recurrence in T1 stage tongue cancer., PMID:15510597
Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1., PMID:15370542
For research use only. Not for human or drug use.
