Catalog No.
PHC44501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human UCHL1 (Gln2-Ala223).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
UCH-L1,PGP 9.5,UCHL1,Ubiquitin carboxyl-terminal hydrolase isozyme L1,Ubiquitin thioesterase L1,Neuron cytoplasmic protein 9.5,PGP9.5
Purification
Purified by antigen affinity column.
Accession
P09936
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Association of neurobiological and immune serum biomarkers with Toxoplasma gondii infection in patients with schizophrenia., PMID:40397143
Inhibition of UCH-L1 enhances immunotherapy efficacy in triple-negative breast cancer by stabilizing PD-L1., PMID:40389130
Epidermal Transient Receptor Potential Vanilloid 1 innervation is increased in patients with painful diabetic polyneuropathy experiencing ongoing burning pain., PMID:39968935
Effect of Anti-TNF Monoclonal Antibody on Enteric Neurons and Enteric Glial Cells in Experimental Colitis., PMID:39946069
A Novel IgG-IgM Autoantibody Panel Enhances Detection of Early-stage Lung Adenocarcinoma from Benign Nodules., PMID:39661479
PGP9.5 expression in human tumors: A tissue microarray study on 13,920 tumors from 120 different tumor entities., PMID:39520970
A study of PGP 9.5 immunohistochemical labeling on formalin-fixed paraffin embedded tissues for epidermal nerve fiber density testing., PMID:39287221
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses., PMID:38135686
Serum Biomarker Profiles Discriminate AQP4 Seropositive and Double Seronegative Neuromyelitis Optica Spectrum Disorder., PMID:38134369
Review of the Role of Rituximab in the Management of Adult Minimal Change Disease and Immune-Mediated Focal and Segmental Glomerulosclerosis., PMID:37901702
Transcriptome sequencing reveals novel molecular features of SLE severity., PMID:37554401
Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress., PMID:36952018
Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions., PMID:36937574
Qixue Shuangbu decoction and acupuncture combined with Western medicine in acute severe stroke patients., PMID:36793635
Decipher potential biomarkers of diagnosis and disease activity for NMOSD with AQP4 using LC-MS/MS and Simoa., PMID:36709595
A cross-sectional study of antibodies to ubiquitin proteasome system in different glomerulopathies., PMID:36472403
Development of a novel bioengineered 3D brain-like tissue for studying primary blast-induced traumatic brain injury., PMID:36200530
Morphometric and immunohistochemical analysis as a method to identify undifferentiated spermatogonial cells in adult subjects with Klinefelter syndrome: a cohort study., PMID:36116982
[Clinical significance of autoantibodies against ubiquitin carboxyl hydrolase L1 epitopes in the screening and diagnosis of Sjögren syndrome]., PMID:36058683
Label-free, ultrasensitive and rapid detection of FDA-approved TBI specific UCHL1 biomarker in plasma using MWCNT-PPY nanocomposite as bio-electrical transducer: A step closer to point-of-care diagnosis of TBI., PMID:35973277
Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1., PMID:35390718
Utility of autoantibody against an UCH-L1 epitope as a serum diagnostic marker for neuropsychiatric systemic lupus erythematosus., PMID:35084329
Biomarkers and Immune Repertoire Metrics Identified by Peripheral Blood Transcriptomic Sequencing Reveal the Pathogenesis of COVID-19., PMID:34504487
Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W., PMID:34326324
Impact of prostatic radiation therapy on bladder contractility and innervation., PMID:34015163
Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice., PMID:33159930
Role of A20/TNFAIP3 deficiency in lupus nephritis in MRL/lpr mice., PMID:31811410
Single-step functionalization of poly-catecholamine nanofilms for ultra-sensitive immunosensing of ubiquitin carboxyl terminal hydrolase-L1 (UCHL-1) in spinal cord injury., PMID:31561093
Histological Corneal Alterations in Keratoconus After Crosslinking-Expansion of Findings., PMID:31513045
Remodeling of Substance P Sensory Nerves and Transient Receptor Potential Melastatin 8 (TRPM8) Cold Receptors After Corneal Experimental Surgery., PMID:31157834
GDNF family receptor alpha 1 is a reliable marker of undifferentiated germ cells in bulls., PMID:31029848
Semaphorin 3A Inhibits Nerve Regeneration During Early Stage after Inferior Alveolar Nerve Transection., PMID:30862799
A20 overexpression exerts protective effects on podocyte injury in lupus nephritis by downregulating UCH-L1., PMID:30805933
Expression of PD-L1 in tumor-associated nerves correlates with reduced CD8+ tumor-associated lymphocytes and poor prognosis in prostate cancer., PMID:30537104
Vascularization via activation of VEGF-VEGFR signaling is essential for peripheral nerve regeneration., PMID:30531158
The clinical significance of ubiquitin carboxyl hydrolase L1 and its autoantibody in neuropsychiatric systemic lupus erythematosus., PMID:30418114
Clinical, electrophysiological, and cutaneous innervation changes in patients with bortezomib-induced peripheral neuropathy reveal insight into mechanisms of neuropathic pain., PMID:30152246
Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy., PMID:30037345
Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification., PMID:29782494
Recovery of the sub-basal nerve plexus and superficial nerve terminals after corneal epithelial injury in mice., PMID:29550279
Co-expression of vasoactive intestinal peptide and protein gene product 9.5 surrounding the lumen of human Schlemm's canal., PMID:29432726
Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice., PMID:29307588
Alarmins in Frozen Shoulder: A Molecular Association Between Inflammation and Pain., PMID:29190116
Inflammatory Renin-Angiotensin System Disruption Attenuates Sensory Hyperinnervation and Mechanical Hypersensitivity in a Rat Model of Provoked Vestibulodynia., PMID:29155208
[The clinical significance of anti- ubiquitin C-terminal hydrolase L1 autoantibodies in the diagnosis of neuropsychiatric systemic lupus erythematosus]., PMID:29141377
Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes., PMID:28667290
Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain., PMID:28326938
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?, PMID:28116572
Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus., PMID:28028361
Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma., PMID:27914685
For research use only. Not for human or drug use.
