Catalog No.
YHE92601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr151
Predicted molecular weight
19.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52594
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AGFG1, Arf-GAP domain and FG repeat-containing protein 1, Rev/Rex activation domain-binding protein, Nucleoporin-like protein RIP, HIV-1 Rev-binding protein, Rev-interacting protein, RIP, HRB, RAB
Upregulation of Receptor Interacting Protein 1 Induced by UVB Contributes to Photodamage of the Skin Through NF-κB Pathway In Vivo and In Vitro., PMID:40062663
Analysis of MLKL, RIP1 and RIP3 Immunostaining Markers in Human Liver Tissue from Fatal Yellow Fever Cases: Insights into Necroptosis., PMID:39861792
[Cisplatin promotes TNF-α autocrine to trigger RIP1/RIP3/MLKL-dependent necroptosis of human head and neck squamous cell carcinoma cells]., PMID:39523095
The role of autophagy in RIP1 mediated cell death and intestinal inflammation., PMID:39271257
AGFG1 increases cholesterol biosynthesis by disrupting intracellular cholesterol homeostasis to promote PDAC progression., PMID:39089666
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells., PMID:39009982
MiR-17∼92 is involved in NF-κB activation via targeting the ubiquitin-editing proteins to mediate RIP1 complex polyubiquitinations in ABC-DLBCL., PMID:38909971
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2., PMID:38227684
Circular RNA AGFG1 motivates breast cancer cell proliferation, invasion, migration, and glycolysis by controlling microRNA-653-5p/14-3-3 protein epsilon., PMID:37851953
Acacetin induces sustained ERK1/2 activation and RIP1-dependent necroptotic death in breast cancer cells., PMID:36740148
Circular RNA circ-AGFG1 contributes to esophageal squamous cell carcinoma progression and glutamine catabolism by targeting microRNA-497-5p/solute carrier family 1 member 5 axis., PMID:36206112
Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1., PMID:35793674
Cell adhesion tunes inflammatory TPL2 kinase signal transduction., PMID:35218437
PLP2-derived peptide Rb4 triggers PARP-1-mediated necrotic death in murine melanoma cells., PMID:35190586
Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis., PMID:35178459
ZFP91 promotes cell proliferation and inhibits cell apoptosis in AML via inhibiting the proteasome-dependent degradation of RIP1., PMID:35165513
Synthesis and biological evaluation of celastrol derivatives as potential anti-glioma agents by activating RIP1/RIP3/MLKL pathway to induce necroptosis., PMID:34968902
ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB., PMID:34839354
Nuclear mRNA Quality Control and Cytoplasmic NMD Are Linked by the Guard Proteins Gbp2 and Hrb1., PMID:34681934
CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression., PMID:34461454
Protein Aggregation and Disaggregation in Cells and Development., PMID:34450138
The Role of Nuclear Factor of Activated T Cells 5 in Hyperosmotic Stress-Exposed Human Lens Epithelial Cells., PMID:34208226
RIP1-Mediated Necroptosis Facilitates Oxidative Stress‒Induced Melanocyte Death, Offering Insight into Vitiligo., PMID:34102211
The Odd Faces of Oligomers: The Case of TRAF2-C, A Trimeric C-Terminal Domain of TNF Receptor-Associated Factor., PMID:34070875
Loss of FADD and Caspases Affects the Response of T-Cell Leukemia Jurkat Cells to Anti-Cancer Drugs., PMID:33800107
ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis., PMID:33786632
Functional amyloids in the human body., PMID:33691165
B. burgdorferi sensu lato-induced inhibition of antigen presentation is mediated by RIP1 signaling resulting in impaired functional T cell responses towards Candida albicans., PMID:33360386
Radiation-induced IL-1β expression and secretion promote cancer cell migration/invasion via activation of the NF-κB-RIP1 pathway., PMID:33176910
TNFR2 is required for RIP1-dependent cell death in human leukemia., PMID:33027529
Nec-1 attenuates inflammation and cytotoxicity induced by high glucose on THP-1 derived macrophages through RIP1., PMID:32805637
Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis., PMID:32632306
Rucaparip (Rubraca®) induces necrosis via upregulating the expression of RIP1 and RIP3 in ovarian cancer cells., PMID:32539918
Giardia duodenalis induces extrinsic pathway of apoptosis in intestinal epithelial cells through activation of TNFR1 and K63 de-ubiquitination of RIP1 in vitro., PMID:32525021
Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes., PMID:32495124
CircAGFG1 aggravates the progression of cervical cancer by downregulating p53., PMID:32141537
Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling., PMID:31898971
RIP1, RIP3, and MLKL Contribute to Cell Death Caused by Clostridium perfringens Enterotoxin., PMID:31848291
Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway., PMID:31706322
CircAGFG1 promotes cervical cancer progression via miR-370-3p/RAF1 signaling., PMID:31703640
HBx combined with AFB1 triggers hepatic steatosis via COX-2-mediated necrosome formation and mitochondrial dynamics disorder., PMID:31282064
EZH2 Regulates Intestinal Inflammation and Necroptosis Through the JNK Signaling Pathway in Intestinal Epithelial Cells., PMID:31273598
CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression., PMID:31243884
RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)., PMID:31198981
Extracts derived from a traditional Chinese herbal formula triggers necroptosis in ectocervical Ect1/E6E7 cells through activation of RIP1 kinase., PMID:31034957
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase., PMID:31013427
Antagonism of RIP1 using necrostatin-1 (Nec-1) ameliorated damage and inflammation of HBV X protein (HBx) in human normal hepatocytes., PMID:30963789
Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway., PMID:30924024
Gallic acid protects against ethanol-induced hepatocyte necroptosis via an NRF2-dependent mechanism., PMID:30853489
Productive transcription of miR-124-3p by RelA and RNA polymerase II directs RIP1 ubiquitination-dependent apoptosis resistance during hypoxia., PMID:30844390
For research use only. Not for human or drug use.
