Anti-IL3 Polyclonal Antibody

Catalog No.

PHC35701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IL3 (Ala20-Phe152).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

IL3,Hematopoietic growth factor,Multipotential colony-stimulating factor,IL-3,Mast cell growth factor,Interleukin-3,P-cell-stimulating factor,MCGF

Purification

Purified by antigen affinity column.

Accession

P08700

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Mouse Th2 cell extracellular vesicles promote eosinophil survival through the surface cytokine cargo IL-3., PMID:40505836

Siglec6 CAR T cells suppressed progression of AML via inhibiting Siglec6 and SHP2 induced Src and ERK signaling activation., PMID:40436895

Enhanced Immunity and Infection Resistance in Mice Through Co-Expression of Porcine IL-3, IL-7, and IL-15 Fusion Molecules in Yarrowia lipolytica., PMID:40282231

Lienal Polypeptide Decreases Immune Thrombocytopenia in a Mouse Model by Upregulating Cytokine Production and Increasing the Levels of CD4+, CD8+, and T Regulatory Cells., PMID:40113259

TRAIL receptor agonist TLY012 in combination with PD-1 inhibition promotes tumor regression in an immune-competent mouse model of pancreatic ductal adenocarcinoma., PMID:39949937

CD131 antagonism blocks inflammation, emphysema and fibrosis in an asthma-COPD overlap mouse model originating in early life., PMID:39814691

FcεRI/PLC axis promotes anandamide synthesis and the formation of CB2-GPR55 heteromers, modulating cytokine production in mast cells., PMID:39732104

Interleukin-3 Modulates Macrophage Phagocytic Activity and Promotes Spinal Cord Injury Repair., PMID:39697159

Defining Optimal Basophil Passive Sensitisation Parameters., PMID:39552263

Unveiling the enigmatic roles of basophils in HIV infection: A narrative review., PMID:39496030

Basophils induce protumorigenic cytokines from A549 lung adenocarcinoma via mechanisms requiring IgE, galectin-3, and IL-3 priming., PMID:39432748

Th2 cell extracellular vesicles promote eosinophil survival through the cytokine cargo IL-3 and prolong airway eosinophilia., PMID:39211207

Novel biomarkers in the saliva of healthy young males and females in a randomized crossover study on sedentary time: An exploratory analysis., PMID:39163400

Reversible ON- and OFF-switch receptors Clec4G and Rab1A reveal the hormetic effects of a pectin polysaccharide in Aralia elata (Miq.) Seem., PMID:39059090

Xin-Yi-Qing-Fei-Tang and its critical components reduce asthma symptoms by suppressing GM-CSF and COX-2 expression in RBL-2H3 cells., PMID:38631485

Sequential engagement of adhesion molecules and cytokine receptors impacts both piecemeal and anaphylactic degranulation of human basophils., PMID:38226657

Leaves and pseudostems extract of Curcuma longa attenuates immunoglobulin E/bovine serum albumin-stimulated bone marrow-derived cultured mast cell activation and passive cutaneous anaphylaxis in BALB/c mice., PMID:38042384

Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade., PMID:37931708

Mechanism of synergistic inhibitory effect of benzyl isothiocyanate and zoledronic acid combination on breast cancer induction of osteoclast differentiation., PMID:37921547

The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function., PMID:37783432

Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy., PMID:37773046

Protective efficacy and correlates of immunity of immunodominant recombinant Babesia microti antigens., PMID:37728332

Myeloid-derived suppressor cells promote the formation of abdominal aortic aneurysms through the IL-3-ICOSL-ICOS axis., PMID:37705722

Effects of leptin on the viability of human ovarian cancer cells and changes in cytokine expression levels., PMID:37155466

Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus., PMID:36810600

Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5., PMID:36740095

Interleukin-3-dependent potentiation of IgE responsiveness in mouse basophils., PMID:36637417

Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123., PMID:36635380

IL-5 and GM-CSF, but Not IL-3, Promote the Proliferative Properties of Inflammatory-like and Lung Resident-like Eosinophils in the Blood of Asthma Patients., PMID:36497064

Immunomodulatory effects of β-defensin 2 on macrophages induced immuno-upregulation and their antitumor function in breast cancer., PMID:36324077

Antiallergic Effects of N,N-dicoumaroylspermidine Isolated from Lithospermum erythrorhizon on Mast Cells and Ovalbumin-Induced Allergic Rhinitis., PMID:36142314

Expression and regulation of Siglec-6 (CD327) on human mast cells and basophils., PMID:35953001

Immunological parameters of recurrent miscarriages among women in Thi-Qar province., PMID:35815084

A Mouse Model of Ulcerative Cutaneous Leishmaniasis by Leishmania (Viannia) panamensis to Investigate Infection, Pathogenesis, Immunity, and Therapeutics., PMID:35770175

Autophagy Protects against Eosinophil Cytolysis and Release of DNA., PMID:35681515

Targeting the human βc receptor inhibits inflammatory myeloid cells and lung injury caused by acute cigarette smoke exposure., PMID:35599245

An optimized protocol for phenotyping human granulocytes by mass cytometry., PMID:35434655

IL-3 signalling in the tumour microenvironment shapes the immune response via tumour endothelial cell-derived extracellular vesicles., PMID:35398240

CD34+ cell of origin for immunoglobulin heavy chain variable region unmutated, but not mutated, chronic lymphocytic leukemia., PMID:35343368

SARS-CoV-2 Induces Cytokine Responses in Human Basophils., PMID:35280992

The Alleviating Effect of Lagerstroemia indica Flower Extract on Stretch Marks through Regulation of Mast Cells., PMID:35209065

Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models., PMID:35145069

The association of IL-3, IL-17A, and IL 27 serum levels with susceptibility to toxoplasmosis in recurrent abortion of Iraqi women., PMID:35085575

Evaluating tagraxofusp for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN)., PMID:35060807

Targeting CD123 in BPDCN: an emerging field., PMID:34607517

Targeting the Human βc Receptor Inhibits Contact Dermatitis in a Transgenic Mouse Model., PMID:34537191

Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells., PMID:34506850

Serum Inflammatory Factor Profiles in the Pathogenesis of High-Altitude Polycythemia and Mechanisms of Acclimation to High Altitudes., PMID:34483727

Latent tuberculosis co-infection is associated with heightened levels of humoral, cytokine and acute phase responses in seropositive SARS-CoV-2 infection., PMID:34329676

iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts., PMID:34112724

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