Catalog No.
YHK58201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn141-Glu266
Predicted molecular weight
17.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UKL0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RCOR1, REST corepressor 1, RCOR, Protein CoREST, KIAA0071
Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV., PMID:40274826
HKDC1 promotes colorectal cancer progression by regulating RCOR1 expression to activate the Wnt/β-catenin pathway, enhancing proliferation, migration, and epithelial-mesenchymal transition., PMID:40209953
Recurrent GRHL fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases., PMID:39564735
LPS-induced neuroinflammation induces changes in the transcriptional profile of members of the CoRest repressive complex in the hippocampus., PMID:39546128
DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor., PMID:39214989
Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort., PMID:39118347
REST and RCOR genes display distinct expression profiles in neurons and astrocytes using 2D and 3D human pluripotent stem cell models., PMID:38975076
Fetal hemoglobin induction in azacytidine responders enlightens methylation patterns related to blast clearance in higher-risk MDS and CMML., PMID:38879530
Neuronal differentiation requires BRAT1 complex to remove REST from chromatin., PMID:38805275
RCOR1 is targeted by miR-23b-3p to modulate growth, colony formation, migration, and invasion of prostate cancer cells., PMID:38455506
OVOL2 sustains postnatal thymic epithelial cell identity., PMID:38012144
RCOR1 improves neurobehaviors and neuron injury in rat cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3β pathway upregulation., PMID:37978036
GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage., PMID:37878419
FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells., PMID:37660196
Genome-wide scan for runs of homozygosity in South American Camelids., PMID:37605116
REST, RCOR1 and RCOR2 expression is reduced in osteoarthritic chondrocytes and contributes to increasing MMP13 and ADAMTS5 expression through upregulating HES1., PMID:37442513
The stem cell-supporting small molecule UM171 triggers Cul3-KBTBD4-mediated degradation of ELM2 domain-harboring proteins., PMID:36997086
Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype., PMID:36586412
Differences in junction-associated gene expression changes in three rat models of diabetic retinopathy with similar neurovascular phenotype., PMID:36526091
Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis., PMID:35890315
ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma., PMID:35794688
Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin., PMID:35322029
Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network., PMID:34732131
Nuclear S-nitrosylation impacts tissue regeneration in zebrafish., PMID:34725362
The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity., PMID:34093866
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank., PMID:33742053
Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans embryonic development., PMID:33740234
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex., PMID:33417871
Expression of the Neural REST/NRSF-SIN3 Transcriptional Corepressor Complex as a Target for Small-Molecule Inhibitors., PMID:33130996
Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites., PMID:32946763
Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171., PMID:32582923
Diverse nucleosome Site-Selectivity among histone deacetylase complexes., PMID:32501215
Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate., PMID:32396821
LINC01198 facilitates gliomagenesis through activating PI3K/AKT pathway., PMID:32378450
RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells., PMID:32306431
MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex., PMID:32251364
Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex., PMID:32101746
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer., PMID:31959826
Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity., PMID:31917688
Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A., PMID:31331073
CoRest1 regulates neurogenesis in a stage-dependent manner., PMID:31301200
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer., PMID:31249575
Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex., PMID:30988160
Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex., PMID:30889214
Molecular architecture of the Jumonji C family histone demethylase KDM5B., PMID:30858420
Molecular mechanisms of bleeding disorderassociated GFI1BQ287* mutation and its affected pathways in megakaryocytes and platelets., PMID:30655368
Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation., PMID:30559927
Is HOTAIR really involved in neuroendocrine prostate cancer differentiation?, PMID:30238772
Influences: Sodium channel excitement., PMID:30030300
Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile., PMID:29949906
For research use only. Not for human or drug use.
