Catalog No.
YHD76901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly59-Pro263
Predicted molecular weight
24.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28074
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MB1, PSMB5, Proteasome subunit MB1, X, Macropain epsilon chain, Proteasome subunit beta type-5, Multicatalytic endopeptidase complex epsilon chain, LMPX, Proteasome subunit X, Proteasome chain 6, Proteasome epsilon chain
Proteasome dysfunction in T cells causes immunodeficiency via cell cycle disruption and apoptosis., PMID:40223594
Xerophenone H, a naturally-derived proteasome inhibitor, triggers apoptosis and paraptosis in lung cancer., PMID:40112632
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration., PMID:39988732
The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation., PMID:39952963
Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression., PMID:39929834
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle., PMID:39878121
Prognostic Value of PSMB5 and Correlations with LC3II and Reactive Oxygen Species Levels in the Bone Marrow Mononuclear Cells of Bortezomib-Resistant Multiple Myeloma Patients., PMID:39852147
Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows., PMID:39809816
Nuclear factor erythroid 2-related factor 1 regulates the expression of proteasomal genes in ketotic cows and protects mammary cells against free fatty acid-induced endoplasmic reticulum stress., PMID:39343197
[Establishment of a stable THP-1 cell line expressing PSMB9-eGFP-His protein and detection of immunoproteasome activity]., PMID:39044591
Mitochondrial Control of Proteasomal Psmb5 Drives the Differentiation of Tissue-Resident Memory T Cells in Patients with Rheumatoid Arthritis., PMID:39037181
PTEN status determines therapeutic vulnerability to celastrol in cholangiocarcinoma., PMID:38851099
Mutant dominant-negative rhodopsin∆I256 causes protein aggregates degraded via ERAD and prevents normal rhodopsin from proper membrane trafficking., PMID:38828393
Proteasome localization and activity in pig brain and in vivo small molecule screening for activators., PMID:38469354
Role of the ubiquitin-proteasome system in the sarcopenic-like phenotype induced by CCL5/RANTES., PMID:38357936
MiR-383 sensitizes osteosarcoma cells to bortezomib treatment via down-regulating PSMB5., PMID:38252234
[Bioinformatics analysis of primary biliary cholangitis key genes and molecular mechanisms]., PMID:38238956
Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations., PMID:38132120
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition., PMID:38097716
Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation., PMID:38009004
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer., PMID:37864031
[Dynamic Changes in the Activities and Contents of Particular Proteasome Forms in the Cerebral Cortex of C57BL/6 Mice during Aging]., PMID:37752653
Ancistrocladinium A Induces Apoptosis in Proteasome Inhibitor-Resistant Multiple Myeloma Cells: A Promising Therapeutic Agent Candidate., PMID:37631095
Hydroquinidine displays a significant anticarcinogenic activity in breast and ovarian cancer cells via inhibiting cell-cycle and stimulating apoptosis., PMID:37529110
Exosomes derived from synovial fibroblasts from patients with rheumatoid arthritis promote macrophage migration that can be suppressed by miR-124-3p., PMID:37151687
Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma., PMID:37149018
High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma., PMID:37111759
Baicalin inhibits pressure overload-induced cardiac hypertrophy by regulating the SIRT3-dependent signaling pathway., PMID:36931095
Bisphenol-A (BPA) Impairs Hippocampal Neurogenesis via Inhibiting Regulation of the Ubiquitin Proteasomal System., PMID:36828952
Construction of noninvasive prognostic model of bladder cancer patients based on urine proteomics and screening of natural compounds., PMID:36562811
Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells., PMID:36553634
Excessive proteostasis contributes to pathology in fragile X syndrome., PMID:36495869
Luteolin Attenuates Diabetic Myocardial Hypertrophy by Inhibiting Proteasome Activity., PMID:36423586
Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy., PMID:36357363
Timed use of digoxin prevents heart ischemia-reperfusion injury through a REV-ERBα-UPS signaling pathway., PMID:38229609
Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma., PMID:36273157
PSMB5 overexpression is correlated with tumor proliferation and poor prognosis in hepatocellular carcinoma., PMID:36062301
PSMB5 Alleviates Ulcerative Colitis by Inhibiting ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis., PMID:36061354
Downregulation of miR-885-5p Promotes NF-κB Pathway Activation and Immune Recruitment in Cutaneous Lupus Erythematosus., PMID:36049539
ISG20L2 suppresses bortezomib antimyeloma activity by attenuating bortezomib binding to PSMB5., PMID:36040812
Synthesis and Discovery of Ligustrazine-Heterocycle Derivatives as Antitumor Agents., PMID:35958230
A clinically relevant pulse treatment generates a bortezomib-resistant myeloma cell line that lacks proteasome mutations and is sensitive to Bcl-2 inhibitor venetoclax., PMID:35896610
A protein-protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity., PMID:35816513
Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates., PMID:35799704
Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome., PMID:35617426
Functional characterization and clinical significance of super-enhancers in lung adenocarcinoma., PMID:35596703
A Data Science Approach for the Identification of Molecular Signatures of Aggressive Cancers., PMID:35565454
A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment., PMID:35246527
Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells., PMID:35121737
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models., PMID:35000546
For research use only. Not for human or drug use.
