Catalog No.
YHK57301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu388-Gly630
Predicted molecular weight
29.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BQI3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Eukaryotic translation initiation factor 2-alpha kinase 1, EIF2AK1, Hemin-sensitive initiation factor 2-alpha kinase, Heme-regulated inhibitor, HRI, Heme-controlled repressor, KIAA1369, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, hHRI, HCR
Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling., PMID:40344059
Reduced White Matter Damage and Lower Neuroinflammatory Potential of Microglia and Macrophages in Hri/Eif2ak1 -/- Mice After Contusive Spinal Cord Injury., PMID:39760211
Transcriptome-wide methylated RNA immunoprecipitation sequencing profiling reveals m6A modification involved in response to heat stress in Apostichopus japonicus., PMID:39528936
STK33 as the functional substrate of miR-454-3p for suppression and apoptosis in neuroblastoma., PMID:39515612
YTHDF2 phase separation promotes arsenic-induced keratinocyte transformation in a poly-m6A-dependent manner by inhibiting translational initiation of the key tumor suppressor PTEN., PMID:39490166
Comprehensive mapping of the Interaction of levodopa and iron metabolism in Parkinson's disease., PMID:39345474
Stress granule-mediated sequestration of EGR1 mRNAs correlates with lomustine-induced cell death prevention., PMID:38940347
Reversible male contraception by targeted inhibition of serine/threonine kinase 33., PMID:38781365
Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients., PMID:38410507
Serine/Threonine Kinase (STK) 33 promotes the proliferation and metastasis of human esophageal squamous cell carcinoma via inflammation-related pathway., PMID:38286054
Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α., PMID:37615898
Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3., PMID:37591251
Identification of genomic biomarkers and their pathway crosstalks for deciphering mechanistic links in glioblastoma., PMID:37277696
STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis., PMID:37146716
Interaction between STK33 and autophagy promoted renal cell carcinoma metastasis by regulating mTOR/ULK1 signaling pathway., PMID:37101009
Genetic Variants Associated with Suicide Risk in the Mexican Population: A Systematic Literature Review., PMID:36772904
The chaperone-assisted selective autophagy complex dynamics and dysfunctions., PMID:36594740
A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing., PMID:36543131
Assessment of eIF2α phosphorylation during immunogenic cell death., PMID:36064228
Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts., PMID:35926182
Multiple Components of Protein Homeostasis Pathway Can Be Targeted to Produce Drug Synergies with VCP Inhibitors in Ovarian Cancer., PMID:35740614
Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing., PMID:35642741
The Rationale for the Dual-Targeting Therapy for RSK2 and AKT in Multiple Myeloma., PMID:35328342
IFN-β Deficiency Results in Fatal or Demyelinating Disease in C57BL/6 Mice Infected With Theiler's Murine Encephalomyelitis Viruses., PMID:35222374
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer., PMID:35163244
Dihydrocapsaicin induces translational repression and stress granule through HRI-eIF2α phosphorylation axis., PMID:34953209
Higher-order phosphatase-substrate contacts terminate the integrated stress response., PMID:34625748
Targeting STK33: from inhibition to degradation., PMID:34605274
NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma., PMID:34536775
Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormalities of the flagella., PMID:34155512
Comparative analysis reveals distinctive epigenetic features of the human cerebellum., PMID:33956822
A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition., PMID:33633164
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction., PMID:33483422
The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics., PMID:33288732
The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates., PMID:33168630
HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation., PMID:32956454
The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress., PMID:32892501
Pathogenesis and promising therapeutics of Alzheimer disease through eIF2α pathway and correspondent kinases., PMID:32681467
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy., PMID:32513922
The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression., PMID:32299090
De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation., PMID:32197074
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway., PMID:32132707
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol., PMID:32132706
Association between genetic polymorphisms and endometrial cancer risk: a systematic review., PMID:32066633
Gene-level genome-wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population., PMID:31578828
STK33 Promotes the Growth and Progression of Human Pancreatic Neuroendocrine Tumour via Activation of the PI3K/AKT/mTOR Pathway., PMID:31261148
Systematic analysis of differentially methylated expressed genes and site-specific methylation as potential prognostic markers in head and neck cancer., PMID:31131446
Oral administration of a new HRI activator as a new strategy to improve high-fat-diet-induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21., PMID:30927369
STK33/ERK2 signal pathway contribute the tumorigenesis of colorectal cancer HCT15 cells., PMID:30760631
Identification of Rfx6 target genes involved in pancreas development and insulin translation by ChIP-seq., PMID:30509498
For research use only. Not for human or drug use.
