Catalog No.
PHC34901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human HCK (Met22-Pro526).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Hemopoietic cell kinase,Tyrosine-protein kinase HCK,p61Hck,p59-HCK/p60-HCK,Hematopoietic cell kinase,p59Hck,HCK
Purification
Purified by antigen affinity column.
Accession
P08631
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Association between hospitalised childhood pneumonia and follow-up chest radiographs in high-risk populations: a secondary analysis of a multicentre randomised controlled trial., PMID:40345826
Inhibition of Kinase Activity and In Vitro Downregulation of the Protein Kinases in Lung Cancer and Cervical Cancer Cell Lines and the Identified Known Anticancer Compounds of Ziziphus mucronata., PMID:39942957
Antibiotics for Paediatric Community-Acquired Pneumonia: What is the Optimal Course Duration?, PMID:39847251
[Screening and validation of therapeutic targets for chronic sinusitis with nasal polyps based on proteomics]., PMID:39107122
The Evolving Role of Bruton's Tyrosine Kinase Inhibitors in B Cell Lymphomas., PMID:39062757
Ligilactobacillus salivarius CCFM 1266 modulates gut microbiota and GPR109a-mediated immune suppression to attenuate immune checkpoint blockade-induced colitis., PMID:37953676
Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors., PMID:37089957
Role of FcγRIII in the nasal cavity of BALB/c mice in the primary amebic meningoencephalitis protection model., PMID:36913025
CD93 is Associated with Glioma-related Malignant Processes and Immunosuppressive Cell Infiltration as an Inspiring Biomarker of Survivance., PMID:36006582
Sialylated and sulfated N-Glycans in MDCK and engineered MDCK cells for influenza virus studies., PMID:35882911
S100A10 Is a New Prognostic Biomarker Related to the Malignant Molecular Features and Immunosuppression Process of Adult Gliomas., PMID:35779750
Cell-Adapted Mutations and Antigenic Diversity of Influenza B Viruses in Missouri, 2019-2020 Season., PMID:34696325
HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels., PMID:34106001
A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model., PMID:32817952
Minimal manifestation status and prednisone withdrawal in the MGTX trial., PMID:32611638
Effect of deoxynivalenol on the porcine acquired immune response and potential remediation by a novel modified HSCAS adsorbent., PMID:32061728
Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients., PMID:31653970
The omics based study for the role of superoxide dismutase 2 (SOD2) in keratinocytes: RNA sequencing, antibody-chip array and bioinformatics approaches., PMID:31345118
Expression and in vitro function of anti-cancer mAbs in transgenic Arabidopsis thaliana., PMID:31234954
Suppression of autophagy and HCK signaling promotes PTGS2high FCGR3- NK cell differentiation triggered by ectopic endometrial stromal cells., PMID:29962266
Prediction for Intravenous Immunoglobulin Resistance by Using Weighted Genetic Risk Score Identified From Genome-Wide Association Study in Kawasaki Disease., PMID:29025760
Monitoring UV-induced signalling pathways in an ex vivo skin organ culture model using phospho-antibody array., PMID:28887818
Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies., PMID:28347651
Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils., PMID:27729551
Randomized Trial of Thymectomy in Myasthenia Gravis., PMID:27509100
Urothelial Barrier Deficits, Suburothelial Inflammation and Altered Sensory Protein Expression in Detrusor Underactivity., PMID:27436428
The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection., PMID:27358479
Designing an Antibody-Based Chaperoning System through Programming the Binding and Release of the Folding Intermediate., PMID:26959507
Development of a novel multiplex beads-based assay for autoantibody detection for colorectal cancer diagnosis., PMID:26915739
High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells., PMID:26785729
Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation., PMID:25972488
CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease., PMID:25605650
Elevated serum IgE may be associated with development of ketamine cystitis., PMID:24859443
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines., PMID:24192080
TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer., PMID:24178904
Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors., PMID:24145282
Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-β1., PMID:24112102
Chaperone-like effects of a scFv antibody on the folding of human muscle creatine kinase., PMID:23798471
Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner., PMID:23755096
A study of the mechanism of the chaperone-like function of an scFv of human creatine kinase by computer simulation., PMID:23637984
The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model., PMID:23439650
High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain., PMID:22792285
Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions., PMID:22345475
Isolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase., PMID:22155429
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice., PMID:21746961
Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs., PMID:20799926
Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice., PMID:20624892
Integrin alphaMbeta2 clustering triggers phosphorylation and activation of protein kinase C delta that regulates transcription factor Foxp1 expression in monocytes., PMID:20190138
Cross-linking of SIGNR1 activates JNK and induces TNF-alpha production in RAW264.7 cells that express SIGNR1., PMID:19520061
Tyrosine kinases and inflammatory signalling., PMID:19199943
For research use only. Not for human or drug use.
