Catalog No.
YHK56901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly387-Asp619
Predicted molecular weight
28.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2E6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RING finger protein 155, Protein deltex-4, RNF155, KIAA0937, RING-type E3 ubiquitin transferase DTX4, E3 ubiquitin-protein ligase DTX4, DTX4, Deltex4
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage., PMID:40403420
p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liver., PMID:39346550
Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L., PMID:39242775
Construction and validation of a ubiquitination-related prognostic risk score signature in breast cancer., PMID:39170352
The Role of NOTCH Pathway Genes in the Inherited Susceptibility to Aortic Stenosis., PMID:39057646
Invasive Breast Cancer: miR-24-2 Targets Genes Associated with Survival and Sensitizes MDA-MB-231 Cells to Berberine., PMID:37669117
Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression through stearoyl-CoA desaturase 1., PMID:37612343
The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer., PMID:37443713
c-Myb Dominates TBK1-Mediated Endotoxin Tolerance in Kupffer Cells by Negatively Regulating DTX4., PMID:37032653
Attenuation of IFN signaling due to m6A modification of the host epitranscriptome promotes EBV lytic reactivation., PMID:36918845
Zika virus alters centrosome organization to suppress the innate immune response., PMID:35793002
The Kinase MAP4K1 Inhibits Cytosolic RNA-Induced Antiviral Signaling by Promoting Proteasomal Degradation of TBK1/IKKε., PMID:34908452
Investigation of Key Signaling Pathways Associating miR-204 and Common Retinopathies., PMID:34646884
Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease., PMID:34513839
MiR-485 targets the DTX4 gene to regulate milk fat synthesis in bovine mammary epithelial cells., PMID:33828164
Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases., PMID:32948590
DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination., PMID:32937373
TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination., PMID:32366851
Identification of novel susceptibility loci associated with hepatitis B surface antigen seroclearance in chronic hepatitis B., PMID:29975729
Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus., PMID:29700819
E3 ubiquitin ligase DTX4 is required for adipogenic differentiation in 3T3-L1 preadipocytes cell line., PMID:28842252
Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing., PMID:28611181
Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction., PMID:28249581
USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome., PMID:27692986
Notch4+ cancer stem-like cells promote the metastatic and invasive ability of melanoma., PMID:27234159
DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation., PMID:26407194
The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling., PMID:23064103
NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4., PMID:22388039
Cross-reactivity of an anti-okadaic acid antibody to dinophysistoxin-4 (DTX-4), dinophysistoxin-5 (DTX-5), and an okadaic acid diol ester., PMID:9690786
For research use only. Not for human or drug use.
