Catalog No.
YHK56301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser81-Thr251
Predicted molecular weight
22.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UPG8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0198, PLAGL2, Zinc finger protein PLAGL2, Pleiomorphic adenoma-like protein 2
Drosha: a new tumor suppressor in pineoblastoma., PMID:40345854
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma., PMID:40240142
Comparative Clinical and Imaging-Based Evaluation of Therapeutic Modalities in CNS Embryonal Tumours With PLAGL Amplification., PMID:40196918
Galactose-Induced Cataracts in Rats: A Machine Learning Analysis., PMID:40027191
PLAGL2-STAU1-NCOA4 axis enhances gastric cancer peritoneal metastasis by resisting ferroptosis via ferritinophagy., PMID:39987411
CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis., PMID:39271290
Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement., PMID:39228008
A Novel CRISPR/Cas9-mediated Mouse Model of Colon Carcinogenesis., PMID:39128652
Hyperoxia exposure induces ferroptosis and apoptosis by downregulating PLAGL2 and repressing HIF-1α/VEGF signaling pathway in newborn alveolar typeII epithelial cell., PMID:39102510
Hemiprotonic ph-ph+ with two targets inhibits metastatic breast cancer and concurrent candidiasis., PMID:38942090
Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop., PMID:38689092
POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression., PMID:38500386
Transcriptional landscape of intestinal environment in DSS-induced ulcerative colitis mouse model., PMID:38308210
Inhibiting the m6A Reader IGF2BP3 Suppresses Ovarian Cancer Cell Growth via Regulating PLAGL2 mRNA Stabilization., PMID:38274714
Identification of LncPVT1 and CircPVT1 as prognostic biomarkers in human colorectal polyps., PMID:37573419
PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling., PMID:37454211
PLAGL2 induces nucleus pulposus cell apoptosis via regulating RASSF5 expression and thus accelerates intervertebral disc degeneration., PMID:37364764
A comprehensive analysis of infantile central nervous system tumors to improve distinctive criteria for infant-type hemispheric glioma versus desmoplastic infantile ganglioglioma/astrocytoma., PMID:37349135
The oncogenic function of PLAGL2 is mediated via ASCL2 and IGF2 and a Wnt-independent mechanism in colorectal cancer., PMID:37310750
TEAD4 predicts poor prognosis and transcriptionally targets PLAGL2 in serous ovarian cancer., PMID:37145265
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis., PMID:36999803
Identification of hub genes and potential molecular mechanisms related to radiotherapy sensitivity in rectal cancer based on multiple datasets., PMID:36879254
Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer., PMID:36807469
Extracellular vesicles secreted by adenomyosis endometrial organoids contain miRNAs involved in embryo implantation and pregnancy., PMID:36697316
PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer., PMID:36620907
Identification of Genetic Effects of ACADVL and IRF6 Genes with Milk Production Traits of Holstein Cattle in China., PMID:36553659
Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification., PMID:36437415
PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway., PMID:36399309
Dual role of pseudogene TMEM198B in promoting lipid metabolism and immune escape of glioma cells., PMID:36038663
PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/β-catenin Pathway., PMID:35777795
Spectrum of paired-like homeobox 2b immunoexpression in pediatric brain tumors with embryonal morphology., PMID:35763016
Overexpression of GATA5 Inhibits Prostate Cancer Progression by Regulating PLAGL2 via the FAK/PI3K/AKT Pathway., PMID:35565203
Comprehensive analysis of negatively correlated miRNA-mRNA regulatory pairs associated with microsatellite instability in colorectal cancer., PMID:35253734
High Expression of PLAGL2 is Associated With Poor Prognosis in High-Grade Glioma., PMID:35222518
Synthesis of Hemiprotonic Phenanthroline-Phenanthroline+ Compounds with both Antitumor and Antimicrobial Activity., PMID:35073076
Novel role of prostate cancer risk variant rs7247241 on PPP1R14A isoform transition through allelic TF binding and CpG methylation., PMID:34849858
Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma., PMID:34586726
LncRNA HCP5 acts as a miR-128-3p sponge to promote the progression of multiple myeloma through activating Wnt/β-catenin/cyclin D1 signaling via PLAGL2., PMID:34331612
MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer., PMID:34320711
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop., PMID:34022398
Long non-coding RNA MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop promotes hepatocellular carcinoma progression., PMID:33596983
PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1., PMID:33391500
Gene biomarker discovery at different stages of Alzheimer using gene co-expression network approach., PMID:32699331
Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis., PMID:32683589
MicroRNA-214-3p targets the PLAGL2-MYH9 axis to suppress tumor proliferation and metastasis in human colorectal cancer., PMID:32413870
PLAGL2-EGFR-HIF-1/2α Signaling Loop Promotes HCC Progression and Erlotinib Insensitivity., PMID:32335942
The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression., PMID:32087738
In silico identification of novel transcription factors associated with CYP27B1 transcriptional regulation in LPS-challenged mononuclear phagocytes., PMID:32001361
Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway., PMID:31911754
PLAGL2 promotes epithelial-mesenchymal transition and mediates colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1., PMID:31827238
For research use only. Not for human or drug use.
