Catalog No.
YHK56201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp239
Predicted molecular weight
29.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H6Z9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PHD3, Hypoxia-inducible factor prolyl hydroxylase 3, Prolyl hydroxylase EGLN3, HPH-3, Prolyl hydroxylase domain-containing protein 3, Egl nine homolog 3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-1, EGLN3
The mechanism of telomerase Cajal body protein 1 regulating senescence of mouse bone marrow mesenchymal stem cells., PMID:40442860
Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer's disease progression., PMID:40435260
Multi-organ transcriptomics provide insights into growth regulation in the Dongtingking crucian carp (Carassius auratus indigentiaus)., PMID:40398212
Geographic Variation in Epigenetic Responses to Hypoxia in Deer Mice (Peromyscus maniculatus) Distributed Along an Elevational Gradient., PMID:40156223
Prolyl hydroxylase domain enzymes (isoforms 1-3, PHD1-3), but not factor-inhibiting HIF-1 (FIH-1), interact with the IKK complex and attenuate LPS-activated NF-kappa-B., PMID:40024754
Mechanistic insights into the role of EGLN3 in pulmonary vascular remodeling and endothelial dysfunction., PMID:39985019
Therapeutic potential of roxadustat in immune thrombocytopenia: a Mendelian randomization analysis., PMID:39756656
Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer's disease., PMID:39701332
Postischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis., PMID:39621585
FOXD2-AS1 Binding to MYC Activates EGLN3 to Affect the Malignant Progression of Clear Cell Renal Cell Carcinoma., PMID:39620435
Unveiling the proteome of the fasting heart: Insights into HIF-1 pathway regulation., PMID:39469441
High expression levels of haem oxygenase-1 promote ferroptosis in macrophage-derived foam cells and exacerbate plaque instability., PMID:39255694
Trans-resveratrol mitigates miR-204-3p mediated progression of allergic rhinitis by regulating the EGLN3/HIF-1α/IL33/ST2 signalling pathway., PMID:39226709
Understanding Hypoxia-Driven Tumorigenesis: The Interplay of HIF1A, DNA Methylation, and Prolyl Hydroxylases in Head and Neck Squamous Cell Carcinoma., PMID:38928200
Endothelial EGLN3-PKM2 signaling induces the formation of acute astrocytic barrier to alleviate immune cell infiltration after subarachnoid hemorrhage., PMID:38755642
Multiple polygenic risk scores can improve the prediction of systemic lupus erythematosus in Taiwan., PMID:38724181
Identification of important modules and biomarkers in diabetic cardiomyopathy based on WGCNA and LASSO analysis., PMID:38469146
Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma., PMID:38400673
Identification of key genes of diabetic cardiomyopathy in hiPSCs-CMs based on bioinformatics analysis., PMID:38381273
Identification of the key DNA damage response genes for predicting immunotherapy and chemotherapy efficacy in lung adenocarcinoma based on bulk, single-cell RNA sequencing, and spatial transcriptomics., PMID:38340438
Transcriptional landscape of intestinal environment in DSS-induced ulcerative colitis mouse model., PMID:38308210
Leukocytes and Endothelial Cells Participate in the Pathogenesis of Alzheimer's Disease: Identifying New Biomarkers Mirroring Metabolic Alterations., PMID:38306052
EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity., PMID:38184692
Expression of prolyl hydroxylase domains, the upstream regulators of HIF, in the brain of the anoxia-tolerant crucian carp during anoxia-reoxygenation., PMID:38145292
Identification of a novel intermittent hypoxia-related prognostic lncRNA signature and the ceRNA of lncRNA GSEC/miR-873-3p/EGLN3 regulatory axis in lung adenocarcinoma., PMID:37842058
β-CATENIN stabilizes HIF2 through lncRNA and inhibits intravenous immunoglobulin immunotherapy., PMID:37744383
Transcriptome profiling reveals transcriptional regulation of Protegrin-1 on immune defense and development in porcine granulosa cells., PMID:37741593
Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo., PMID:37155893
CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways., PMID:37127576
Spatially multicellular variability of intervertebral disc degeneration by comparative single-cell analysis., PMID:37025067
E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression., PMID:36882523
In silico Identification of Hypoxic Signature followed by reverse transcription-quantitative PCR Validation in Cancer Cell Lines., PMID:36624663
Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells., PMID:36400902
Identification and validation of a 9-gene signature for the prognosis of ovarian cancer by integrated bioinformatical analysis., PMID:36330389
Application of miRNA Biomarkers in Predicting Overall Survival Outcomes for Lung Adenocarcinoma., PMID:36147635
Hypoxia-inducible factor pathway genes predict survival in metastatic clear cell renal cell carcinoma., PMID:35973929
Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways., PMID:35862273
Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCDcl1 Cells., PMID:35806266
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome., PMID:35760869
The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation., PMID:35705735
Unique mutations in mitochondrial DNA and associated pathways involved in high altitude pulmonary edema susceptibility in Indian lowlanders., PMID:35666092
A novel hypoxia-driven gene signature that can predict the prognosis of hepatocellular carcinoma., PMID:35549979
Multiple Sclerosis Biomarker Candidates Revealed by Cell-Type-Specific Interactome Analysis., PMID:35483054
Genome-Wide Knockout Screen Identifies EGLN3 Involving in Ammonia Neurotoxicity., PMID:35425766
Evolution, characterization, and expression profile of Egl-9 family hypoxia-inducible factor (egln) in rainbow trout (Oncorhynchus mykiss) under hypoxia stress., PMID:35289728
Potential biomarkers and the molecular mechanism associated with DLL4 during renal cell carcinoma progression., PMID:35289275
Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth., PMID:35124697
PHD3 as a Prognosis Marker and its Relationship with Immune Infiltration in Lung Adenocarcinoma., PMID:35088661
Tumor innervation is triggered by endoplasmic reticulum stress., PMID:34785777
Discovery and construction of prognostic model for clear cell renal cell carcinoma based on single-cell and bulk transcriptome analysis., PMID:34733651
For research use only. Not for human or drug use.
