Catalog No.
YXX09601
Expression system
E. coli
Species
Staphylococcus aureus
Protein length
Asp29-Asn312
Predicted molecular weight
34.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
B1Q037
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LukS-PV, lukS-PV
Whole-genome sequencing analysis of Staphylococcus aureus isolated from female patients with mastitis in Henan, China., PMID:40419111
Staphylococcus aureus in Rwandan dogs predominantly representing human-associated lineages., PMID:40287395
Genomic detection of Panton-Valentine Leucocidins encoding genes, virulence factors and distribution of antiseptic resistance determinants among Methicillin-resistant S. aureus isolates from patients attending regional referral hospitals in Tanzania., PMID:39833938
Toxin protein LukS-PV targeting complement receptor C5aR1 inhibits cell proliferation in hepatocellular carcinoma via the HDAC7-Wnt/β-catenin axis., PMID:39736396
Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique., PMID:38730020
TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection., PMID:37671153
Genus-wide genomic characterization of Macrococcus: insights into evolution, population structure, and functional potential., PMID:37547688
Cytotoxic and apoptotic effects of chemically synthesized silver nanoparticles loaded with recombinant Staphylococcus LukS-PV toxin., PMID:37421980
The anticancer effect of recombinant LukS-PV protein and silver nanoparticles loaded with this protein., PMID:37289339
Genomic epidemiology of bovine mastitis-causing Staphylococcus aureus in New Zealand., PMID:37099864
LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression., PMID:35676659
A fatal case of pneumonia and sepsis caused by sequence type 398 methicillin-susceptible Staphylococcus aureus carrying Pantone-Valentine leukocidin in China., PMID:35654720
LukS-PV inhibits the proliferation of hepatocellular carcinoma cells by maintaining FOXO3 stability via the PI3K/AKT signaling pathway., PMID:35589047
Epidemiological and clinical features of Panton-Valentine Leukocidin positive Staphylococcus aureus bacteremia: A case-control study., PMID:35303019
Penicillin susceptibility among invasive MSSA infections: a multicentre study in 16 Spanish hospitals., PMID:34245259
Development of Combination Vaccine Conferring Optimal Protection against Six Pore-Forming Toxins of Staphylococcus aureus., PMID:34227839
Impaired T-Lymphocyte Responses During Childhood Staphylococcus aureus Infection., PMID:34145461
Spa typing of Staphylococcus aureus Isolated from Clinical Specimens from Outpatients in Iraq., PMID:33815529
Panton-Valentine Leukocidin Induces Cytokine Release and Cytotoxicity Mediated by the C5a Receptor on Rabbit Alveolar Macrophages., PMID:33518621
Detection of methicillin-resistant coagulase-negative staphylococci and PVL/mecA genes in cefoxitin-susceptible Staphylococcus aureus (t044/ST80) from unpasteurized milk sold in stores in Djelfa, Algeria., PMID:33455787
Presence of egc-positive major clones ST 45, 30 and 22 among methicillin-resistant and methicillin-susceptible oral Staphylococcus aureus strains., PMID:33144661
Identification of a domain critical for Staphylococcus aureus LukED receptor targeting and lysis of erythrocytes., PMID:33051210
Genome Sequence of a Highly Virulent pvl-positive Vancomycin-intermediate-resistant Staphylococcus aureus Sequence Type 30., PMID:32655307
LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression., PMID:32637573
Diversity of bacteriophages encoding Panton-Valentine leukocidin in temporally and geographically related Staphylococcus aureus., PMID:32040487
LukS-PV induces cell cycle arrest and apoptosis through p38/ERK MAPK signaling pathway in NSCLC cells., PMID:31708104
Genetic characterisation of staphylococci of food-producing animals in Senegal. PVL detection among MSSA., PMID:31684939
Panton-Valentine Positive Staphylococcus aureus in Community-Acquired and Hospital-Acquired Pediatric Infections., PMID:31568145
Genomic and Epidemiological Evidence of a Dominant Panton-Valentine Leucocidin-Positive Methicillin Resistant Staphylococcus aureus Lineage in Sri Lanka and Presence Among Isolates From the United Kingdom and Australia., PMID:31080781
Whole genome sequencing of a ST2594 MRSA strain causing non-mucosal preoperative colonization and low-grade postoperative infection., PMID:30663019
Evidence of latent molecular diversity determining the virulence of community-associated MRSA USA300 clones in mice., PMID:30091216
Molecular characterization of clonal lineage and staphylococcal toxin genes from S. aureus in Southern Nigeria., PMID:30013850
Rim domain loops of staphylococcal β-pore forming bi-component toxin S-components recognize target human erythrocytes in a coordinated manner., PMID:29474554
Prevalence and characterisation of Staphylococcus aureus causing community-acquired skin and soft tissue infections on Java and Bali, Indonesia., PMID:29124834
Above and beyond C5a Receptor Targeting by Staphylococcal Leucotoxins: Retrograde Transport of Panton-Valentine Leucocidin and γ-Hemolysin., PMID:28117704
Staphylococcus aureus from the German general population is highly diverse., PMID:28017539
Molecular characterisation of Panton-Valentine leucocidin-producing methicillin-resistant Staphylococcus aureus clones isolated from the main hospitals in Taif, KSA., PMID:27934826
Is LukS-PV a novel experimental therapy for leukemia?, PMID:27916717
LukS-PV induces differentiation by activating the ERK signaling pathway and c-JUN/c-FOS in human acute myeloid leukemia cells., PMID:27102414
Staphylococcus aureus Nasal Carriage among Beefpacking Workers in a Midwestern United States Slaughterhouse., PMID:26866374
Development of a novel multiplex electrochemiluminescent-based immunoassay for quantification of human serum IgG against 10 Staphylococcus aureus toxins., PMID:26826278
Characterization of MRSA strains by phenotypic and OCR-based methods., PMID:29616532
Methicillin-Resistant Staphylococcus aureus USA300 Latin American Variant in Patients Undergoing Hemodialysis and HIV Infected in a Hospital in Bogotá, Colombia., PMID:26474075
Antibodies to S. aureus LukS-PV Attenuated Subunit Vaccine Neutralize a Broad Spectrum of Canonical and Non-Canonical Bicomponent Leukotoxin Pairs., PMID:26367030
α-Defensins partially protect human neutrophils against Panton-Valentine leukocidin produced by Staphylococcus aureus., PMID:25963798
Internalization of staphylococcal leukotoxins that bind and divert the C5a receptor is required for intracellular Ca(2+) mobilization by human neutrophils., PMID:25737084
Molecular characterization of Staphylococcus aureus from nasal samples of healthy farm animals and pets in Tunisia., PMID:25700041
LukS-PV, a component of Panton-Valentine leukocidin, exerts potent activity against acute myeloid leukemia in vitro and in vivo., PMID:25601295
Genetic diversity and virulence potential of Staphylococcus aureus isolates from raw and processed food commodities in Shanghai., PMID:25485928
[Laboratory-based evaluation of PVL-RPLA "Seiken" to detect Panton-Valentine leukocidin produced by Staphylococcus aureus]., PMID:25151771
For research use only. Not for human or drug use.
