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Anti-ERCC1 Polyclonal Antibody

Catalog #:   PHC29301 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P07992
Overview

Catalog No.

PHC29301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ERCC1 (Met1-Pro297).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

ERCC1,DNA excision repair protein ERCC-1

Purification

Purified by antigen affinity column.

Accession

P07992

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with ERCC1 antibody (PHC29301) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 35 kDa
    Observed MW: 35 kDa
References

Assessing expression patterns of PTGR1, a potential biomarker for acylfulven sensitivity in urothelial carcinoma., PMID:39523403

Association of ERCC1 rs11615 Polymorphism with the Risk of Cervical Cancer Especially in Chinese Populations: A Meta-Analysis., PMID:36245993

Does Molecular Profiling of KRAS-Mutant Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Help in Treatment Strategy Planning?, PMID:35877239

Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma., PMID:35668940

Evidence for Diverse Prognosis in High-Grade Serous Ovarian Carcinoma: Solid, Pseudoendometrioid, and Transitional-Like; So-Called "SET Morphology" and Progesterone Receptor Status., PMID:35147976

A newly established monoclonal antibody against ERCC1 detects major isoforms of ERCC1 in gastric cancer., PMID:34532603

Quantitative Multiplexed Proteomics Could Assist Therapeutic Decision Making in Non-Small Cell Lung Cancer Patients with Ambiguous ALK Test Results., PMID:34066104

ERCC1 Is a Predictive Biomarker for Non-small Cell Lung Cancer But Is Antibody-dependent., PMID:33952496

Determining the molecular landscape and impact on prognosis in HPV-associated head and neck cancer., PMID:32944296

Evaluating genomic biomarkers associated with resistance or sensitivity to chemotherapy in patients with advanced breast and colorectal cancer., PMID:32847480

Clinicopathological correlation of the expression of excision repair cross complementation group 1 (ERCC1) in oral cavity squamous cell carcinomas: an immunohistochemical study., PMID:32602295

ERCC1 expression in advanced colorectal cancer and matched liver metastases., PMID:32008866

Phase II trial of a non-platinum triplet for patients with advanced non-small cell lung carcinoma (NSCLC) overexpressing ERCC1 messenger RNA., PMID:30628188

Gap Junction Intercellular Communication Positively Regulates Cisplatin Toxicity by Inducing DNA Damage through Bystander Signaling., PMID:30279363

MAVERICC, a Randomized, Biomarker-stratified, Phase II Study of mFOLFOX6-Bevacizumab versus FOLFIRI-Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer., PMID:30224341

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine., PMID:29992976

ERCC1 assessment in upfront treatment with and without cisplatin-based chemotherapy in stage IIIB/IV non-squamous non-small cell lung cancer., PMID:29905882

A novel antibody-based approach to detect the functional ERCC1-202 isoform., PMID:29482102

Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice., PMID:29415265

ERCC1 as predictive biomarker to platinum-based chemotherapy in adrenocortical carcinomas., PMID:29187510

An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum., PMID:28821816

ASCO 2016 - update colorectal liver metastases., PMID:28725278

Randomized Prospective Biomarker Trial of ERCC1 for Comparing Platinum and Nonplatinum Therapy in Advanced Non-Small-Cell Lung Cancer: ERCC1 Trial (ET)., PMID:27893326

Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1-/Δ7 Mice., PMID:27774093

Development and Validation of an ERCC1 Immunohistochemistry Assay for Solid Tumors., PMID:27610644

The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells., PMID:27473273

Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model., PMID:27467592

Establishment of a multimarker qPCR panel for the molecular characterization of circulating tumor cells in blood samples of metastatic breast cancer patients during the course of palliative treatment., PMID:27223437

Microglia replenished OHSC: A culture system to study in vivo like adult microglia., PMID:27145902

Prognostic role of ERBB2, MET and VEGFA expression in metastatic colorectal cancer patients treated with anti-EGFR antibodies., PMID:27002940

Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy., PMID:26868521

RRM1, ERCC1 and TS1 Immunofluorescence Expression in Leiomyosarcoma: A Tissue Microarray Study with Clinical Outcome Correlation Analysis., PMID:26612755

Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study., PMID:26372896

The prognostic and predictive value of excision repair cross-complementation group 1 (ERCC1) protein in 1288 patients with head and neck squamous cell carcinoma treated with platinum-based therapy: a meta-analysis., PMID:26179868

Xenograft assessment of predictive biomarkers for standard head and neck cancer therapies., PMID:25619980

Treatment effect of buparlisib, cetuximab and irradiation in wild-type or PI3KCA-mutated head and neck cancer cell lines., PMID:25603975

ERCC1-positive circulating tumor cells in the blood of ovarian cancer patients as a predictive biomarker for platinum resistance., PMID:25015375

Comparison of two ERCC1 antibodies as prognostic and predictive biomarkers for early non-small cell lung cancer., PMID:24982391

Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer., PMID:24817012

Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions., PMID:24799992

Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas., PMID:24692084

Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody., PMID:24603753

Phase II Trial of Target-guided Personalized Chemotherapy in First-line Metastatic Colorectal Cancer., PMID:24517959

ERCC1 expression correlated with EGFR and clinicopathological variables in patients with non-small cell lung cancer. An immunocytochemical study on fine-needle aspiration biopsies samples., PMID:24508180

Trastuzumab and oxaliplatin exhibit a synergistic antitumor effect in HER2-postive gastric cancer cells., PMID:24300914

Predictive biomarkers in patients with resected non-small cell lung cancer treated with perioperative chemotherapy., PMID:24293473

Quantification of excision repair cross-complementing group 1 and survival in p16-negative squamous cell head and neck cancers., PMID:24088734

ERCC1 is a prognostic biomarker in locally advanced head and neck cancer: results from a randomised, phase II trial., PMID:24064970

A phase II clinical study of mFOLFOX6 plus bevacizumab as first-line therapy for Japanese advanced/recurrent colorectal cancer patients., PMID:23999770

ERCC1 isoform expression and DNA repair in non-small-cell lung cancer., PMID:23514287

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-ERCC1 Polyclonal Antibody [PHC29301]
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