Catalog No.
YHE28201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn24-Lys338
Predicted molecular weight
35.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P40926
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Malate dehydrogenase, mitochondrial, MDH2
Altered Lactylation Myocardial Tissue May Contribute to a More Severe Energy-Deprived State of the Tissue and Left Ventricular Outflow Tract Obstruction in HOCM., PMID:40281739
Genetic and metabolic insights into sexual dimorphism in the flexor carpi radialis of Asiatic toads (Bufo gargarizans) associated with amplexus behavior., PMID:39994541
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification., PMID:39962087
FSH exacerbates bone loss by promoting osteoclast energy metabolism through the CREB-MDH2-NAD+ axis., PMID:39880362
GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression., PMID:39738099
Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention., PMID:39595553
Nodularin-R Synergistically Enhances Abiraterone Against Castrate- Resistant Prostate Cancer via PPP1CA Inhibition., PMID:39550701
Detoxification and benefits on acute heart failure in mice- of fuziline using glycyrrhetinic acid: an integrated biochemical analysis., PMID:39545061
MDH2 Promotes Hepatocellular Carcinoma Growth Through Ferroptosis Evasion via Stabilizing GPX4., PMID:39519171
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2., PMID:39454581
Biomarkers and pathways in autism spectrum disorder: An individual meta-analysis based on proteomic and metabolomic data., PMID:39361099
Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia-reperfusion injury., PMID:39357647
Malate dehydrogenase-2 inhibition shields renal tubular epithelial cells from anoxia-reoxygenation injury by reducing reactive oxygen species., PMID:39287333
MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1., PMID:39138167
USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition., PMID:38973363
Multi-omics revealed anti-fatigue property of polyphenol from areca nut., PMID:38964153
Physiology of malate dehydrogenase and how dysregulation leads to disease., PMID:38962852
Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of mitochondrial fission., PMID:38852800
Chemoproteomic Profiling of Signaling Metabolite Fructose-1,6-Bisphosphate Interacting Proteins in Living Cells., PMID:38775806
Gene regulatory network analysis identifies MYL1, MDH2, GLS, and TRIM28 as the principal proteins in the response of mesenchymal stem cells to Mg2+ ions., PMID:38689715
Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase., PMID:38609156
Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in intracranial aneurysms., PMID:38511055
Photosensitive Hydrogel with Temperature-Controlled Reversible Nano-Apertures for Single-Cell Protein Analysis., PMID:38483955
Induced pluripotent stem cell-derived hepatocytes reveal TCA cycle disruption and the potential basis for triheptanoin treatment for malate dehydrogenase 2 deficiency., PMID:38425868
Transcription Factor STAT3-Activated LDHB Promotes Tumor Properties of Endometrial Cancer Cells by Inducing MDH2 Expression., PMID:38381377
Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake via Direct Inhibition of Mitochondrial Malate Dehydrogenase in Mouse 3T3-L1 Cells., PMID:38339168
Molecular insights into sarcopenia: ferroptosis-related genes as diagnostic and therapeutic targets., PMID:38229237
A Rare Variant in MDH2 (rs111879470) Is Associated with Predisposition to Recurrent Breast Cancer in an Extended High-Risk Pedigree., PMID:38136396
Complex I, V, and MDH2 deficient human skin fibroblasts reveal distinct metabolic signatures by 1 H HR-MAS NMR., PMID:38084664
Developmental and epileptic encephalopathy 82 (DEE82) with novel compound heterozygous mutations of GOT2 gene., PMID:37977948
SUMOylation Modulates Reactive Oxygen Species (ROS) Levels and Acts as a Protective Mechanism in the Type 2 Model of Diabetic Peripheral Neuropathy., PMID:37947589
Protein lysine acetylation played an important role in NH3-induced AEC2 damage and pulmonary fibrosis in piglets., PMID:37939958
Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas., PMID:37869643
The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma., PMID:37867526
Therapeutic targeting of FUBP3 phase separation by GATA2-AS1 inhibits malate-aspartate shuttle and neuroblastoma progression via modulating SUZ12 activity., PMID:37537343
Cryopreservation Induces Acetylation of Metabolism-Related Proteins in Boar Sperm., PMID:37446160
Clinicopathological significance of unraveling mitochondrial pathway alterations in non-small-cell lung cancer., PMID:37310411
The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis., PMID:37221841
Intermittent fasting promotes adipocyte mitochondrial fusion through Sirt3-mediated deacetylation of Mdh2., PMID:36815302
Sodium Butyrate Ameliorates Fluorosis-Induced Neurotoxicity by Regulating Hippocampal Glycolysis In Vivo., PMID:36710293
Bioinformatic Analysis of Genetic Factors from Human Blood Samples and Postmortem Brains in Parkinson's Disease., PMID:36593912
Potential Role of Seven Proteomics Tissue Biomarkers for Diagnosis and Prognosis of Prostate Cancer in Urine., PMID:36553191
Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation., PMID:36460681
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia., PMID:36301191
Inhibition of Malate Dehydrogenase-2 Protects Renal Tubular Epithelial Cells from Anoxia-Reoxygenation-Induced Death or Senescence., PMID:36291624
Differential expression of aerobic oxidative metabolism-related proteins in diabetic urinary exosomes., PMID:36187097
Integrated genomic, transcriptomic and metabolomic analysis reveals MDH2 mutation-induced metabolic disorder in recurrent focal segmental glomerulosclerosis., PMID:36159820
Structural Comparison of hMDH2 Complexed with Natural Substrates and Cofactors: The Importance of Phosphate Binding for Active Conformation and Catalysis., PMID:36139014
Proteomics study of mitochondrial proteins in tilapia red meat and their effect on color change during storage., PMID:36084591
Ketogenic Diet Treatment of Defects in the Mitochondrial Malate Aspartate Shuttle and Pyruvate Carrier., PMID:36079864
For research use only. Not for human or drug use.
